BHT (Butylated Hydroxytoluene) NOAEL Studies

COSMOS DB 36 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS DB	LOAEL	800	mg/kg bw/day	mouse	oral	7-13 Gestation day	Developmental	PAFA; ASP
COSMOS DB	NOAEL	3.2	mg/kg bw/day	rabbit	oral	13 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	4	mg/kg bw/day	dog	oral	365 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	6	mg/kg bw/day	rat	oral	365 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	12.5	mg/kg bw/day	rat	oral	175 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	25	mg/kg bw/day	rat	oral	90 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	34	mg/kg bw/day	chinese hamster	oral	14 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	50	mg/kg bw/day	rat	oral	730 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	58	mg/kg bw/day	mouse	oral	14 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	75	mg/kg bw/day	mouse	oral	305 day	Carcinogenicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	85	mg/kg bw/day	guinea pig	oral	14 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	100	mg/kg bw/day	rat	oral	49 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	150	mg/kg bw/day	mouse	oral	700 day	Carcinogenicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	160	mg/kg bw/day	rat	oral	730 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	180	mg/kg bw/day	mouse	oral	10 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	200	mg/kg bw/day	rat	oral	560 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	225	mg/kg bw/day	rat	oral	10 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	240	mg/kg bw/day	mouse	oral	7 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	250	mg/kg bw/day	rat	oral	224 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	280	mg/kg bw/day	hamster	oral	5 day	Developmental	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	300	mg/kg bw/day	rat	oral	175 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	330	mg/kg bw/day	rat	oral	224 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	400	mg/kg bw/day	mouse	oral	1 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	408	mg/kg bw/day	guinea pig	oral	17 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	450	mg/kg bw/day	mouse	oral	756 day	Carcinogenicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	465	mg/kg bw/day	mouse	oral	49 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	500	mg/kg bw/day	rat	oral	730 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	600	mg/kg bw/day	mouse	oral	672 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	608	mg/kg bw/day	mouse	oral	NA	Multigeneration Reproductive	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	620	mg/kg bw/day	rat	oral	49 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	660	mg/kg bw/day	rat	oral	161 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	698	mg/kg bw/day	rat	oral	28 day	Special Toxicology Study	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	700	mg/kg bw/day	rat	oral	28 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	750	mg/kg bw/day	mouse	oral	1036 day	Chronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	790	mg/kg bw/day	dog	oral	365 day	Subchronic	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB	NOAEL	918	mg/kg bw/day	rat	oral	7 day	Short Term Toxicity	US FDA CFSAN PAFA; US FDA CFSAN PAFA Study

EFSA 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA	NOAEL	=25	mg/kg bw/day	Rat	oral: feed	-	reproduction toxicity	EFSA ANS - 2012 - OutputID 490 - development - developmental - Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive - doi:10.2903/j.efsa.2012.2588
EFSA	ADI	=0.25	mg/kg bw/day	Consumers	-	-	ADI	EFSA ANS - 2012 - OutputID 490 - Consumers - Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive - doi:10.2903/j.efsa.2012.2588
EFSA	NOAEL	=25	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive. doi:10.2903/j.efsa.2012.2588.; TITLE=Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2588; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15614340:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0144a6ce3f3b00a57f7c5a829ddb999c

IARC Monographs 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
IARC Monographs	IARC carcinogenicity classification	3	IARC group	-	-	1987	IARC Monographs	-

NTP ICE acute oral 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute oral	LD50	=890	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2094; row=3749; data_type=In Vivo; mixture=Chemical; chemical_name=Butylated hydroxytoluene; preferred_name=Butylated hydroxytoluene; dtxsid=DTXSID2020216; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020216; source_file=acute_oral.xlsx
NTP ICE acute oral	LD50	>6000	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	record_id=acute_oral_2096; row=3750; data_type=In Vivo; mixture=Chemical; chemical_name=Butylated hydroxytoluene; preferred_name=Butylated hydroxytoluene; dtxsid=DTXSID2020216; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020216; source_file=acute_oral.xlsx

NTP ICE cancer 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE cancer	IARC group	3	unitless	-	-	-	WOE; IARC Carcinogenicity	sheet=Data; excel_row=2277; Record_ID=cancer_6431; Data_Type=WOE; Formulation_Name=Butylated hydroxytoluene; Mixture=Chemical; DTXSID=DTXSID2020216; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/58; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216
NTP ICE cancer	Top dose	6000	ppm	Rat	-	-	In Vivo; NTP Carcinogenicity	sheet=Data; excel_row=2269; Record_ID=cancer_6432; Data_Type=In Vivo; Formulation_Name=Butylated hydroxytoluene; Mixture=Chemical; DTXSID=DTXSID2020216; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=6000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-150; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr150/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216

NTP ICE endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Agonist	sheet=Integrated_approaches; excel_row=5902; RecordID=ARPathway2016_761; DatasetName=ARPathway2016; DTXSID=DTXSID2020216; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020216; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020216

SCCS Opinion 30 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
SCCS Opinion	NOAEL	=0.5	%	rat	oral	90 days	NOAEL study	p.32
SCCS Opinion	NOAEL	=7	-	-	-	-	NOAEL study	p.24
SCCS Opinion	NOAEL	=10	mg/kg bw/day	rat	-	24 wk	NOAEL study	Ref.: Modified from EDC dossier 2019, p.35
SCCS Opinion	NOAEL	=15	mg/kg bw/day	-	-	-	NOAEL study	Ref.: Modified from EDC dossier 2019, p.35
SCCS Opinion	NOAEL	=15	-	rat	-	18 wk	NOAEL study	p.34
SCCS Opinion	NOAEL	=20	mg/kg/day	rat	-	8 wk	NOAEL study	p.33
SCCS Opinion	NOAEL	=25	mg/kg bw	rat	-	Chronic	reproductive toxicity	p.17
SCCS Opinion	NOAEL	=25	mg/kg bw/day	rat	-	-	carcinogenicity	p.25
SCCS Opinion	NOAEL	=25	-	-	-	-	NOAEL study	p.24
SCCS Opinion	NOAEL	=28	-	rat	-	28 days	NOAEL study	p.35
SCCS Opinion	NOAEL	=30	-	rat	-	8 wk	NOAEL study	p.34
SCCS Opinion	NOAEL	=32	-	-	-	-	NOAEL study	p.32
SCCS Opinion	NOAEL	=33	-	-	-	-	NOAEL study	p.33
SCCS Opinion	NOAEL	=34	-	-	-	-	NOAEL study	p.34
SCCS Opinion	NOAEL	=35	-	-	-	-	NOAEL study	p.35
SCCS Opinion	NOAEL	=38	mg/kg bw/day	rat	-	-	carcinogenicity	Ref.: EFSA 2012, p.19
SCCS Opinion	NOAEL	=50	-	-	-	4 wk	NOAEL study	p.33
SCCS Opinion	NOAEL	=67	-	rat	-	-	NOAEL study	p.32
SCCS Opinion	NOAEL	=75	-	rat	-	76 wk	NOAEL study	p.35
SCCS Opinion	NOAEL	=100	-	rat	oral	22 weeks	NOAEL study	p.33
SCCS Opinion	NOAEL	=125	-	rat	-	104 wk	NOAEL study	p.34
SCCS Opinion	NOAEL	=200	-	rat	-	24 wk	NOAEL study	p.35
SCCS Opinion	NOAEL	=225	-	rat	-	105 wk	NOAEL study	p.34
SCCS Opinion	NOAEL	=247	mg/kg bw/day	rat	-	-	carcinogenicity	Ref.: Brooks 1976, p.19
SCCS Opinion	NOAEL	=250	-	-	-	-	NOAEL study	p.34
SCCS Opinion	NOAEL	=450	mg/kg bw/day	rat	-	Chronic	reproductive toxicity	Ref.: EFSA 2012, p.17
SCCS Opinion	NOAEL	=500	-	rat	oral	14 wk	NOAEL study	p.33
SCCS Opinion	NOAEL	=515	-	-	-	107 wk	NOAEL study	p.34
SCCS Opinion	NOAEL	=1636	-	rat	oral	144 wk	NOAEL study	p.33
SCCS Opinion	NOAEL	=1640	-	-	-	104 wk	NOAEL study	p.34

ECHA 53 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ECHA	LEL	>=23	mg/kg bw/day	Mouse	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823212_15823213:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3bb95b8169bcffc8589edebe7fa64a7
ECHA	LEL	=100	mg/kg bw/day	Rat	oral	chronic; 14 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ce3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839242_15839243_15839244:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ba5cb63e1e2e154f72de49b0c9180c1
ECHA	LEL	=125	mg/kg bw/day	Rat	oral	chronic; 104 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836171_15836172:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8cc5b5ad30e23f32a84de95593eec04e
ECHA	LEL	=185	mg/kg bw/day	Mouse	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2165fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817340_15819075:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57dd9810fa29a267880f6d2a3d71a748
ECHA	LEL	=200	mg/kg bw/day	Mouse	injection	-	acute	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ccce4b096bca8773732; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/5?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15815633:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac169636416b41379879986676b41e66
ECHA	LEL	=250	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818421_15818745_15819262:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6bd4bc4b469efb7ee4af6c3daa3d980
ECHA	LEL	~333	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b653c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857319_15857783:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a714264d32c1633a0bbf283312fbe4b2
ECHA	LEL	=500	mg/kg bw/day	Rat	oral	chronic; 104 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836171_15836172:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13732e713ffd1458ac315b3bc7cd1403
ECHA	LEL	=538.05	mg/m3	Mouse	inhalation	-	acute	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15799127:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c30238f73d43f4a98d6c0a1d77b046a
ECHA	LEL	<=608	mg/kg bw/day	Mouse	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf69; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823212_15823213:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2e8f36e341d14c87a3b4d9dccf6f65a1
ECHA	LEL	>=669	mg/kg bw/day	Rat	oral	subchronic; 40 days	subchronic	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838212_15846931_15846932:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89f82654065851e39533ddaa6b9abaf3
ECHA	LEL	<=864	mg/kg bw/day	Rat	oral	subchronic; 40 days	subchronic	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838212_15846931_15846932:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29cb12c26eb646665c4b76dfb6245dc2
ECHA	LEL	~900	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817032_15817033_15817034:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4ec4bff2ee4d149b1bb082f65e40708b
ECHA	LEL	=925	mg/kg bw/day	Mouse	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2165fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817341_15819073_15819074:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8dffa2a399b222ca14440350d1a6bb49
ECHA	LEL	>=940	mg/kg bw/day	Cat	oral	-	acute	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15813947_15813948:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_82bf96c31b6e00b8d1645b558d944b74
ECHA	LEL	<=2100	mg/kg bw/day	Cat	oral	-	acute	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15813947_15813948:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab2d9b69d14394eeca3d18feb482c5ef
ECHA	LEL	=3000	ppm	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8afe4b0a7c65d219b52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857764_15857840:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_571cf0f90f60b5f56bdb27299f9fcdc0
ECHA	LEL	<=3200	mg/kg bw/day	Rabbit	oral	-	acute	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15814231_15814232:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31d6e17bf4b42a6d96095e7deec5c999
ECHA	LEL	>=3480	mg/kg bw/day	Mouse	oral	subchronic; 10 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847149_15847150:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38737647da1e5c51c1ddbd541e7ce52f
ECHA	LEL	<=4130	mg/kg bw/day	Mouse	oral	subchronic; 10 weeks	subchronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cef; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847149_15847150:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73e0dfbbda4767f0ddb4f19c09429c6c
ECHA	LEL	=10700	mg/kg bw/day	Guinea Pig	oral	-	acute	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/3/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15804472:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8560478a155fa1656021f0a2b666fffa
ECHA	LOAEL	=15	mg/kg bw/day	Rat	oral	short-term; 1 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834865_15834866:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_48590910ad932865d8b2c26379c9953c
ECHA	LOAEL	=100	mg/kg bw/day	Rat	oral	short-term; 3 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221812; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837763_15837764_15837765:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_096258fbb862dcaa9032c4195ed00b5c
ECHA	LOAEL	=160	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819203_15819204_15819205:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c2f287b3d730d69085595c5a21872abd
ECHA	LOAEL	=167	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822124_15822786_15822868_15823121:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5b40da71847064f9aecfa9f6e39862b
ECHA	LOAEL	=225	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819246_15819247_15819879_15819880_15819881_15819882:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef3deb0ba0e5763df86c7bee9e8c7516
ECHA	LOAEL	=250	mg/kg bw/day	Rat	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be4e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34499/7/9/3?documentUUID=c664dab6-36ff-4cc4-8d00-5af27c01d424; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: changes in litter size and weights; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820919:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b9d8c2541461882640346477335cc38
ECHA	LOAEL	=326	mg/kg bw/day	Rat	oral	short-term; 1 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217c2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834865_15834866:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f399e980ea3322ed7becae5adb0fe155
ECHA	LOAEL	~450	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817032_15817033_15817034:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccb14b723c979f40c81be4dba74f71ae
ECHA	LOAEL	=500	mg/kg bw/day	Rat	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf79; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821618:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a61f90ee852f512237ce2e957ddbf2b0
ECHA	LOAEL	=643	mg/kg bw/day	Rat	oral	short-term; 3 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221880; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=blood: haematology|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|mortality/survival; STUDY_GROUP=ECHA IUCLID:15845166:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6445ec1d097fa0aa9535ca852622e998
ECHA	LOAEL	=750	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be4ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34499/7/9/3?documentUUID=c664dab6-36ff-4cc4-8d00-5af27c01d424; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=maternal: early or late resorptions|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15822516:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c00b667e74b37110a0bf43df57930267
ECHA	LOAEL	=1000	mg/kg bw/day	Rat	oral	short-term; 7 days	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217b4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|haematology|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15831095:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fa36b77f1bbc161bd5d51d12dc2a38d
ECHA	LOAEL	~3480	mg/kg bw/day	Mouse	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d216600; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15819076:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c3f461e1a9b4ff98c3d47bbb7b07331
ECHA	LOEL	=462.5	mg/kg bw/day	Mouse	oral	chronic; 18 months	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ced; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15841838:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1c8635fc672547335c4ac0904fabaec8
ECHA	LOEL	=500	mg/kg bw/day	Rat	oral	acute; 1 days	acute	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221891; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15845816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a8e02a7064950c7de65b069216ca26d
ECHA	NOAEL	=10	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819203_15819204_15819205:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b65091e0820e9c95e384f5621e546bc9
ECHA	NOAEL	=23.4	mg/kg bw/day	Rat	oral	chronic; 18 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2caf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15830440:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e4ef6b35aa1b5a6f3b1845a8e62e5c0
ECHA	NOAEL	=25	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15817283:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58cc9f0de4e1bce14c26039c6535f9eb
ECHA	NOAEL	=27.8	mg/kg bw/day	Rat	oral	short-term; 4 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2cf5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15846300:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24bb0d5f15f0b640699f54d6f545cacd
ECHA	NOAEL	=50	mg/kg bw/day	Monkey	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822398_15822799:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_114f2e063eb4e71d34999adea4d8b9a9
ECHA	NOAEL	>=61	mg/kg bw/day	Pig	oral	subchronic; 42 days	subchronic	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221878; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15844980:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1967e043e200445686e8b93db79be32b
ECHA	NOAEL	~70	mg/kg bw/day	Rat	oral	short-term; 1 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d2217df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15837605:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7bd396475fa4fe6df4fbeeab96e43fa
ECHA	NOAEL	=75	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/8?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819246_15819247_15819879_15819880_15819881_15819882:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_047848372848aa2c9165bfb0a5c4aa4f
ECHA	NOAEL	=100	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b653e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855410_15856228_15857465_15857899_15857912_15857930:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be24d92faeb4548826d7e72b1fbe3dcc
ECHA	NOAEL	=180	mg/kg bw/day	Mouse	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822077_15822824:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c069c37238be5920deb8d6c0635e2ec
ECHA	NOAEL	=225	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821931_15822612:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6693b6d1d597155a72303c566a299526
ECHA	NOAEL	=280	mg/kg bw/day	Hamster	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822134_15822289:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4aff9a1b1de7d4a81d60453f1df6f733
ECHA	NOAEL	=500	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1a6e4b0a7c65d22f7b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822124_15822786_15822868_15823121:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93fe5d3629e5dc5cda6754d833e7e5b4
ECHA	NOAEL	=608	mg/kg bw/day	Mouse	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6538; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=F2: developmental neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15860198:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8d6baf77658fd234f254ee191658fbb
ECHA	NOAEL	=660	mg/kg bw/day	Mouse	oral	short-term; 30 days	short-term	QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead28e4b0a7c65d1c2ce5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15839620:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1733d00ae3fda40e561ac43697e14b3d
ECHA	NOAEL	=800	mg/kg bw/day	Mouse	oral	-	developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/9/3?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820723_15821516:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_219dfd5f9e22b598198702a6ce53f9cf
ECHA	NOEL	=10	mg/kg bw/day	Rat	oral	short-term; 3 weeks	short-term	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca5de4b0a7c65d221812; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15975/7/6/2?documentUUID=81337846-206f-4eb9-8fb6-19030540d018; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15837762:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f39b7d691ff490703fac65b834ed8ecb

ToxValDB ECOTOX 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB ECOTOX	LOEL	=1	%	Rat	oral	subchronic; 56 days	subchronic	LONG_REF=Toxicol. Lett.55(3): 263-272 Shibata,M.A., E. Asakawa, A. Hagiwara, Y. Kurata, and S. Fukushima DNA Synthesis and Scanning Electron Microscopic Lesions in Renal Pelvic Epithelium of Rats Treated with Bladder Cancer Promoters 1991; TITLE=DNA Synthesis and Scanning Electron Microscopic Lesions in Renal Pelvic Epithelium of Rats Treated with Bladder Cancer Promoters; AUTHOR=Shibata,M.A., E. Asakawa, A. Hagiwara, Y. Kurata, and S. Fukushima; DOI=10.1016/0378-4274(91)90006-r; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107545; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594699_15594700:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2ca1b8b7e050a958d47ae76b15d17eb5
ToxValDB ECOTOX	LOEL	=100	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603124_15603125:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a06e71228789dc971eb8c4afd6d07bc
ToxValDB ECOTOX	NOEL	=10	mg/kg bw/day	Mouse	oral	acute; 1 days	acute	LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603124_15603125:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c82c6e5b9f35fe860115fa0763315ca6
ToxValDB ECOTOX	NOEL	=900	mg/kg bw/day	Rat	oral	short-term; 1.625 days	short-term	LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15599293:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9d4aa838b928802667ea70ef7074a504
ToxValDB ECOTOX	NOEL	=1000	mg/kg bw/day	Mouse	oral	short-term; 2 days	short-term	LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15600045:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8bdc4b118257ddb5ba1d4e8de3ab69e5

ToxValDB GESTIS DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB GESTIS DNEL	DNEL systemic	=1.76	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631031:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0828a1c059bd09eec7cf03170b731d05

ToxValDB PPRTV (CPHEA) 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB PPRTV (CPHEA)	RfD (provisional)	=0.3	mg/kg bw/day	Human	oral	-	Toxicity Value	LONG_REF=Olsen et al. 1986; AUTHOR=Olsen et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b379; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1615; TOXICOLOGICAL_EFFECT=Decreased F1 adult weight at 138 weeks in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653687_15653771:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2bff1d6d1c25603e1efde4d3ea29f288
ToxValDB PPRTV (CPHEA)	RfD (provisional)	=1	mg/kg bw/day	Human	oral	-	Toxicity Value	LONG_REF=Olsen et al. 1986; AUTHOR=Olsen et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b379; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1615; TOXICOLOGICAL_EFFECT=Decreased F1 adult weight at 9 weeks in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653687_15653771:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c2ba44f53b00fdbc281ceeab762debe

Regulatory source 44 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
Regulatory source	-	0.5	%	rat	oral	90 days	-	p.32
Regulatory source	-	7	-	-	-	-	-	p.24
Regulatory source	-	10	mg/kg bw/day	rat	-	24 wk	-	p.35
Regulatory source	-	10	-	rat	-	104 wk	-	p.34
Regulatory source	-	15	mg/kg bw/day	-	-	-	-	p.35
Regulatory source	-	15	-	rat	-	18 wk	-	p.34
Regulatory source	-	20	mg/kg/day	rat	-	8 wk	-	p.33
Regulatory source	-	25	mg/kg bw	-	oral	-	-	p.24
Regulatory source	-	25	-	-	-	-	-	p.24
Regulatory source	-	25	-	-	dermal	-	-	p.24
Regulatory source	-	25	-	-	oral	-	-	p.24
Regulatory source	-	25	-	rat	-	144 wk	-	p.32
Regulatory source	-	25	-	rat	-	-	-	p.32
Regulatory source	-	25	-	rat	-	90 days	-	p.34
Regulatory source	-	25	-	rat	-	28 days	-	p.34
Regulatory source	-	28	-	rat	-	28 days	-	p.35
Regulatory source	-	30	-	rat	-	8 wk	-	p.34
Regulatory source	-	32	-	-	-	-	-	p.32
Regulatory source	-	33	-	-	-	-	-	p.33
Regulatory source	-	34	-	-	-	-	-	p.34
Regulatory source	-	35	-	-	-	-	-	p.35
Regulatory source	-	50	-	-	-	4 wk	-	p.33
Regulatory source	-	67	-	rat	-	-	-	p.32
Regulatory source	-	75	-	rat	-	76 wk	-	p.35
Regulatory source	-	100	-	rat	oral	22 weeks	-	p.33
Regulatory source	-	100	-	rat	-	6 wk	-	p.33
Regulatory source	-	100	-	-	-	-	-	p.33
Regulatory source	-	125	-	rat	-	104 wk	-	p.34
Regulatory source	-	200	-	rat	-	24 wk	-	p.35
Regulatory source	-	225	-	rat	-	105 wk	-	p.34
Regulatory source	-	250	-	-	-	-	-	p.34
Regulatory source	-	500	-	rat	oral	14 wk	-	p.33
Regulatory source	-	500	-	-	-	-	-	p.33
Regulatory source	-	515	-	-	-	107 wk	-	p.34
Regulatory source	-	1636	-	rat	oral	144 wk	-	p.33
Regulatory source	-	1636	-	rat	-	104 wk	-	p.34
Regulatory source	-	1636	-	rat	oral	16 wk	-	p.35
Regulatory source	-	1640	-	-	-	104 wk	-	p.34
Regulatory source	carcinogenicity	25	mg/kg bw/day	rat	-	-	carcinogenicity	p.25
Regulatory source	carcinogenicity	38	mg/kg bw/day	rat	-	-	carcinogenicity	p.19
Regulatory source	carcinogenicity	247	mg/kg bw/day	rat	-	-	carcinogenicity	p.19
Regulatory source	reproductive toxicity	25	mg/kg bw	rat	-	Chronic	reproductive toxicity	p.17
Regulatory source	reproductive toxicity	25	mg/kg bw/day	rat	-	-	reproductive toxicity	p.19
Regulatory source	reproductive toxicity	450	mg/kg bw/day	rat	-	Chronic	reproductive toxicity	p.17

openFDA substances 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	1P9D0Z171K	UNII	-	-	-	chemical	-