Is Bis-Demethoxycurcumin safe in cosmetics?
Bis-Demethoxycurcumin has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
Bis-Demethoxycurcumin
Also known as: 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-, 1,6-Heptadiene-3,5-dione, 1,7-bis(p-hydroxyphenyl)-, (E,E)-, (1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, Bisdesmethoxycurcumin, Curcumin III (+4 more)
INCI: BIS-DEMETHOXYCURCUMIN
Bis-Demethoxycurcumin (CAS 33171-05-0) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning (natural curcuminoid from Curcuma longa). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 33171-05-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Skin Conditioning (natural curcuminoid from Curcuma longa)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
InChIKey
PREBVFJICNPEKM-YDWXAUTNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted as cosmetic ingredient; curcumin approved as color additive under 21 CFR 73.600 for drugs/food — cosmetic colorant use requires separate listing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bis-Demethoxycurcumin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Bis-Demethoxycurcumin.
Known Synonyms
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-
1,6-Heptadiene-3,5-dione, 1,7-bis(p-hydroxyphenyl)-, (E,E)-
(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione
Bisdesmethoxycurcumin
Curcumin III
Didemethoxycurcumin
1,7-Bis(4-hydroxyphenyl)-1,6-Heptadiene-3,5-dione
Bis(4-hydroxycinnamoyl)methane
Bis(p-hydroxycinnamoyl)methane
Chemical Function
Antioxidant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BISDEMETHOXYCURCUMIN
ChEMBL ID
CHEMBL105350
Frequently Asked Questions
Is Bis-Demethoxycurcumin allowed in the EU?
Bis-Demethoxycurcumin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bis-Demethoxycurcumin do in cosmetics?
Bis-Demethoxycurcumin functions as: Antioxidant, Skin Conditioning (natural curcuminoid from Curcuma longa). It is classified as a cosmetic ingredient in our database. CAS number: 33171-05-0.
Is Bis-Demethoxycurcumin used outside cosmetics?
Bis-Demethoxycurcumin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bis-Demethoxycurcumin compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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