Bis-Demethoxycurcumin

INCI: BIS-DEMETHOXYCURCUMIN

CAS Number
33171-05-0
Function
Antioxidant, Skin Conditioning (natural curcuminoid from Curcuma longa)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted as cosmetic ingredient; curcumin approved as color additive under 21 CFR 73.600 for drugs/food โ€” cosmetic colorant use requires separate listing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Curcuminoids are photodegradable and potentially phototoxic; assess photostability in formulation. Yellow staining potential. If used as colorant, may trigger Annex IV classification requirements in EU.

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Concern Level: Moderate

Frequently Asked Questions

Is Bis-Demethoxycurcumin safe in cosmetics?

Curcuminoids are photodegradable and potentially phototoxic; assess photostability in formulation. Yellow staining potential. If used as colorant, may trigger Annex IV classification requirements in EU. The EU classifies Bis-Demethoxycurcumin as "permitted". Safety rating: GOOD.

Is Bis-Demethoxycurcumin allowed in the EU?

Bis-Demethoxycurcumin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bis-Demethoxycurcumin do in cosmetics?

Bis-Demethoxycurcumin functions as: Antioxidant, Skin Conditioning (natural curcuminoid from Curcuma longa). It is classified as a cosmetic ingredient in our database. CAS number: 33171-05-0.

What is the Margin of Safety for Bis-Demethoxycurcumin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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