Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer

INCI: BIS-HEA POLYDIETHYLENEGLYCOL ADIPATE/IPDI COPOLYMER

CAS Number
Not publicly assigned for the HEA variant (the related HEMA variant, BIS-HEMA POLY(DIGLYCOL ADIPATE)/IPDI COPOLYMER, carries CAS 2389147-81-1)
Function
Nail conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - no specific prohibition or restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Residual HEA (skin sensitizer) and unreacted IPDI (isophorone diisocyanate - respiratory sensitizer, classified H334/H317 under CLP). The polymerized form is considered safe; however, strict quality control of residual monomer content is essential. Adipate esters are generally well-tolerated.. Polyurethane acrylate incorporating a flexible polyester soft segment (diethylene glycol adipate) and IPDI hard segment, end-capped with HEA for UV curability; provides flexibility and adhesion in nail ...

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer safe in cosmetics?

Residual HEA (skin sensitizer) and unreacted IPDI (isophorone diisocyanate - respiratory sensitizer, classified H334/H317 under CLP). The polymerized form is considered safe; however, strict quality control of residual monomer content is essential. Adipate esters are generally well-tolerated.. Polyurethane acrylate incorporating a flexible polyester soft segment (diethylene glycol adipate) and IPDI hard segment, end-capped with HEA for UV curability; provides flexibility and adhesion in nail ... The EU classifies Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer as "permitted". Safety rating: MODERATE.

Is Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer allowed in the EU?

Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer do in cosmetics?

Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer functions as: Nail conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned for the HEA variant (the related HEMA variant, BIS-HEMA POLY(DIGLYCOL ADIPATE)/IPDI COPOLYMER, carries CAS 2389147-81-1).

What is the Margin of Safety for Bis-HEA Polydiethyleneglycol Adipate/IPDI Copolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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