NOAEL Studies Cosmetic Ingredient

Bixin NOAEL Studies

INCI: CI 75120

CAS: 6983-79-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =191 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2016 - OutputID 2865 - clinical chemistry - nephrotoxicity - The safety of annatto extracts (E 160b) as a food additive - doi:10.2903/j.efsa.2016.4544
EFSA NOAEL =1206 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2016 - OutputID 2865 - clinical chemistry - nephrotoxicity - The safety of annatto extracts (E 160b) as a food additive - doi:10.2903/j.efsa.2016.4544
EFSA ADI =6 mg/kg bw/day Consumers - - ADI EFSA - 2017 - OutputID 2992 - Consumers - Exposure assessment of annatto colouring principles bixin and norbixin (E 160b) when used as food additives - doi:10.2903/j.efsa.2017.4966
EFSA ADI =0.3 mg/kg bw/day Consumers - - ADI EFSA FAF - 2019 - OutputID 3275 - Consumers - Safety of annatto E and the exposure to the annatto colouring principles bixin and norbixin (E 160b) when used as a food additive - doi:10.2903/j.efsa.2019.5626
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9L7T4VB66G UNII - - - chemical -