Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl

INCI: BROMOPHENYL PROPENAMINOETHYL ISOQUINOLINESULFONAMIDE HCL

CAS Number
Not publicly established (specialty synthetic active)
Function
Skin conditioning (likely a Rho-kinase / ROCK inhibitor derivative for anti-wrinkle/hair growth applications)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not established โ€” no NOAEL, no dermal absorption data

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Severe data gap. Pharmacologically active compound (kinase inhibitor). Without a full toxicological dossier (genotox, repeat-dose, repro-tox, dermal penetration), this ingredient cannot pass CPSR assessment. The pharmacological mechanism of action raises concerns about systemic effects even at low concentrations. Supplier must provide comprehensive safety data package.

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Concern Level: High

Frequently Asked Questions

Is Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl safe in cosmetics?

Severe data gap. Pharmacologically active compound (kinase inhibitor). Without a full toxicological dossier (genotox, repeat-dose, repro-tox, dermal penetration), this ingredient cannot pass CPSR assessment. The pharmacological mechanism of action raises concerns about systemic effects even at low concentrations. Supplier must provide comprehensive safety data package. The EU classifies Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl as "permitted". Safety rating: POOR.

Is Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl allowed in the EU?

Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl do in cosmetics?

Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl functions as: Skin conditioning (likely a Rho-kinase / ROCK inhibitor derivative for anti-wrinkle/hair growth applications). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly established (specialty synthetic active).

What is the Margin of Safety for Bromophenyl Propenaminoethyl Isoquinolinesulfonamide HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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