NOAEL Studies
Cosmetic Ingredient
Bumetrizole NOAEL Studies
INCI: BUMETRIZOLE
CAS: 3896-11-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 3000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=7bfc8015-7f32-4000-896a-6c77a83f9faf_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=7bfc8015-7f32-4000-896a-6c77a83f9faf/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-30; basis=other:; key_result=false; entry_uuid=c45c6bcb-6729-4cb1-ae6c-3b8348853b20 |
| ECHA | NOAEL | ca.637 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=12b29493-f9a2-49cc-a6d8-eafda0904254_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=12b29493-f9a2-49cc-a6d8-eafda0904254/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; ReportDate=1968-09-17; basis=other:; key_result=false; entry_uuid=8c301dfa-86d8-4efe-b6c5-de65a8e765ba |
| ECHA | NOAEL | ca.740 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=12b29493-f9a2-49cc-a6d8-eafda0904254_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=12b29493-f9a2-49cc-a6d8-eafda0904254/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; ReportDate=1968-09-17; basis=other:; key_result=false; entry_uuid=d3c38f34-30c5-4a73-86e9-7e36edab26d0 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=e6983e91-6650-4f45-b268-b825f577b247_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=e6983e91-6650-4f45-b268-b825f577b247/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-01-30; basis=other:; key_result=false; entry_uuid=5463cf20-ed49-4fa3-89f0-fa16233ba60b |
| ECHA | NOAEL | >60.3 | mg/kg bw/day | mouse | oral: feed | - | carcinogenicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=427684a9-4010-426f-a6cd-8d6e3780c869_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=427684a9-4010-426f-a6cd-8d6e3780c869/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1981; ReportDate=1981-09-29; basis=other:; key_result=false; entry_uuid=ae8943e8-30af-49e2-b282-596b6fbd2947 |
| ECHA | NOAEL | ca.168 | mg/kg bw/day | dog | oral: feed | - | sub-chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=17f77e1a-cceb-4519-bce5-141fb3a27b8b_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=17f77e1a-cceb-4519-bce5-141fb3a27b8b/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1981; ReportDate=1981-06-26; basis=other:; key_result=false; entry_uuid=a43f2443-ddba-40fc-9d69-f596e92a96a7 |
| ECHA | NOAEL | ca.153 | mg/kg bw/day | dog | oral: feed | - | sub-chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=17f77e1a-cceb-4519-bce5-141fb3a27b8b_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=17f77e1a-cceb-4519-bce5-141fb3a27b8b/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1981; ReportDate=1981-06-26; basis=other:; key_result=false; entry_uuid=4a00d532-e92f-4045-8a3d-2ec97d5f4174 |
| ECHA | NOAEL | ca.1005.7 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=2e985e9a-1441-4b39-81ae-5a4348aa7e23_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=2e985e9a-1441-4b39-81ae-5a4348aa7e23/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1968; ReportDate=1968-09-17; basis=other:; key_result=false; entry_uuid=e6001bef-e22e-45d1-828b-b384bf1a626c |
| ECHA | NOAEL | 59 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=20331bc7-0798-4cee-8fb1-d2cc8dc54d77_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=20331bc7-0798-4cee-8fb1-d2cc8dc54d77/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1981; ReportDate=1981-09-29; basis=other:; key_result=false; entry_uuid=dba235cb-3c07-45fd-bffb-5b4a4180611a |
| ECHA | NOAEL | 62 | mg/kg bw/day | mouse | oral: feed | - | chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=20331bc7-0798-4cee-8fb1-d2cc8dc54d77_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=20331bc7-0798-4cee-8fb1-d2cc8dc54d77/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1981; ReportDate=1981-09-29; basis=other:; key_result=false; entry_uuid=3ce7fc14-4b6f-4f3f-9f5f-09233ca816e1 |
| ECHA | NOEL | ca.113.2 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=458427e2-f244-4e1e-888e-2df71fc471d5_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=458427e2-f244-4e1e-888e-2df71fc471d5/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-05-26; basis=other:; key_result=false; entry_uuid=2434ad0b-4362-4df8-ba53-2365d61e6cd6 |
| ECHA | NOEL | 147.7 | mg/kg bw/day | rat | oral: feed | - | chronic toxicity: oral | dossier=d132c85c-b143-40fa-a60c-74cce800d4dc.i6z; document=458427e2-f244-4e1e-888e-2df71fc471d5_d132c85c-b143-40fa-a60c-74cce800d4dc.i6d; document_key=458427e2-f244-4e1e-888e-2df71fc471d5/d132c85c-b143-40fa-a60c-74cce800d4dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-05-26; basis=other:; key_result=false; entry_uuid=0e6c1ffd-9b40-4a7b-824a-ae36dd04e6f8 |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_6211; row=16150; data_type=In Vivo; mixture=Chemical; chemical_name=Bumetrizole; preferred_name=Bumetrizole; dtxsid=DTXSID9036438; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9036438; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9036438; source_file=acute_oral.xlsx |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 7ZF18Q354W | UNII | - | - | - | chemical | - |