CIR_vision_codex 16 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
CIR_vision_codex	NOAEL	=0.419	g/kg/day	rat	oral	17 days	developmental toxicity	{"citation":"2, 29, 42; 49; 17","dose":"Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"2, 29, 42, and 49. The females were killed 17 days after the start of their mating period and the uterine contents were examined for total implant sites, dead and viable fetuses, and resorptions. There was no significant increase in fetal death rates duringanyof the mating periods. BBP was not considered a dominant lethal mutagen or a reproductive toxicant to CD-l or B6C3Fl mice under the conditions of the study. Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of m...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_001"}
CIR_vision_codex	NOAEL	=0.1	%	rat	oral	2 weeks	developmental toxicity	{"citation":"(51); 0,0; 5, 1","dose":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of minimal maternal toxicity and significant developmental toxicity. At the two higher concentrations, there were significant maternal and embryo effects, including 90% prenatal mortality. Groups of 10 male F344 rats were fed BBP at concentrations of 0.625, 1.25, 2.5, or 5.0% (w/w) in the diet. (43) An additional group of 10 rats served as controls. The rats were maintained on their respective diets for 2 weeks, then killed on da...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_002"}
CIR_vision_codex	NOAEL	=0.419	-	CD rats	oral (diet)	gestation day 6 to 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_1_field_1989_cd_rats_developmental"}
CIR_vision_codex	NOAEL	=0.182	-	CD-1 mice	oral (feed)	gestation day 6 through 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_2_ntp_1990_cd1_mice_developmental"}
CIR_vision_codex	NOAEL	=0.419	g/kg/day	rat	oral	17 days	developmental toxicity	{"citation":"2, 29, 42; 49; 17","dose":"Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"2, 29, 42, and 49. The females were killed 17 days after the start of their mating period and the uterine contents were examined for total implant sites, dead and viable fetuses, and resorptions. There was no significant increase in fetal death rates duringanyof the mating periods. BBP was not considered a dominant lethal mutagen or a reproductive toxicant to CD-l or B6C3Fl mice under the conditions of the study. Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of m...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_001"}
CIR_vision_codex	NOAEL	=0.1	%	rat	oral	2 weeks	developmental toxicity	{"citation":"(51); 0,0; 5, 1","dose":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of minimal maternal toxicity and significant developmental toxicity. At the two higher concentrations, there were significant maternal and embryo effects, including 90% prenatal mortality. Groups of 10 male F344 rats were fed BBP at concentrations of 0.625, 1.25, 2.5, or 5.0% (w/w) in the diet. (43) An additional group of 10 rats served as controls. The rats were maintained on their respective diets for 2 weeks, then killed on da...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_002"}
CIR_vision_codex	NOAEL	=0.419	-	CD rats	oral (diet)	gestation day 6 to 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_1_field_1989_cd_rats_developmental"}
CIR_vision_codex	NOAEL	=0.182	-	CD-1 mice	oral (feed)	gestation day 6 through 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_2_ntp_1990_cd1_mice_developmental"}
CIR_vision_codex	NOAEL	=0.419	g/kg/day	rat	oral	17 days	developmental toxicity	{"citation":"2, 29, 42; 49; 17","dose":"Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"2, 29, 42, and 49. The females were killed 17 days after the start of their mating period and the uterine contents were examined for total implant sites, dead and viable fetuses, and resorptions. There was no significant increase in fetal death rates duringanyof the mating periods. BBP was not considered a dominant lethal mutagen or a reproductive toxicant to CD-l or B6C3Fl mice under the conditions of the study. Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of m...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_001"}
CIR_vision_codex	NOAEL	=0.1	%	rat	oral	2 weeks	developmental toxicity	{"citation":"(51); 0,0; 5, 1","dose":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of minimal maternal toxicity and significant developmental toxicity. At the two higher concentrations, there were significant maternal and embryo effects, including 90% prenatal mortality. Groups of 10 male F344 rats were fed BBP at concentrations of 0.625, 1.25, 2.5, or 5.0% (w/w) in the diet. (43) An additional group of 10 rats served as controls. The rats were maintained on their respective diets for 2 weeks, then killed on da...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_002"}
CIR_vision_codex	NOAEL	=0.419	-	CD rats	oral (diet)	gestation day 6 to 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_1_field_1989_cd_rats_developmental"}
CIR_vision_codex	NOAEL	=0.182	-	CD-1 mice	oral (feed)	gestation day 6 through 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_2_ntp_1990_cd1_mice_developmental"}
CIR_vision_codex	NOAEL	=0.419	g/kg/day	rat	oral	17 days	developmental toxicity	{"citation":"2, 29, 42; 49; 17","dose":"Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"2, 29, 42, and 49. The females were killed 17 days after the start of their mating period and the uterine contents were examined for total implant sites, dead and viable fetuses, and resorptions. There was no significant increase in fetal death rates duringanyof the mating periods. BBP was not considered a dominant lethal mutagen or a reproductive toxicant to CD-l or B6C3Fl mice under the conditions of the study. Field et al.(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of m...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_001"}
CIR_vision_codex	NOAEL	=0.1	%	rat	oral	2 weeks	developmental toxicity	{"citation":"(51); 0,0; 5, 1","dose":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15.","effect":"(51) exposed CD rats to 0,0.5, 1.25, or 2.0% BBP in the diet on gestation day 6 to 15. The no-observed-adverse effect level (NOAEL) for all maternal and embryo effects was established at the average dose of 0.419 g/kg/day. Significant maternal and fetal toxicity was reported at the average dose of 1.64 g/kg/day. The National Toxicology Program’“2’ evaluated the maternal and developmental toxicity in CD-l mice. BBP (0,O. 1,0.5, 1.25, or 2.0% in feed) was administered on day 6 through 15 of the gestation period. The NOAEL for maternal and developmental toxicity was in the groups receiving 0.1% BBP (0.182 g/kg/day). At the 0.5% dose level, there was evidence of minimal maternal toxicity and significant developmental toxicity. At the two higher concentrations, there were significant maternal and embryo effects, including 90% prenatal mortality. Groups of 10 male F344 rats were fed BBP at concentrations of 0.625, 1.25, 2.5, or 5.0% (w/w) in the diet. (43) An additional group of 10 rats served as controls. The rats were maintained on their respective diets for 2 weeks, then killed on da...","page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"pr109_noael_002"}
CIR_vision_codex	NOAEL	=0.419	-	CD rats	oral (diet)	gestation day 6 to 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_1_field_1989_cd_rats_developmental"}
CIR_vision_codex	NOAEL	=0.182	-	CD-1 mice	oral (feed)	gestation day 6 through 15	NOAEL study	{"page":17,"pdf":"pr109.pdf","row_type":"noael_study","study_id":"noael_2_ntp_1990_cd1_mice_developmental"}

California Proposition 65 6 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
California Proposition 65	California Proposition 65 MADL	ABoral=1200	ug/day	-	-	2005-12-02	Maximum allowable dose level	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 MADL	ABoral=1200	ug/day	-	-	2005-12-02	Maximum allowable dose level	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 MADL	ABoral=1200	ug/day	-	-	2005-12-02	Maximum allowable dose level	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental	listing type	-	-	2005-12-02	California Proposition 65 listing	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental	listing type	-	-	2005-12-02	California Proposition 65 listing	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental	listing type	-	-	2005-12-02	California Proposition 65 listing	{"cancer_reproductive":"developmental","listed_date":"2005-12-02","listing_mechanism":"AB","madl":"oral=1200","nsrl":null,"source_table":"prop65_listings"}

EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx	NOAEL	=50	mg/kg bw/day	Rat	oral: feed	-	reproduction toxicity	EFSA AFC - 2005 - OutputID 355 - development - teratogenic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBP) for use in food contact materials - doi:10.2903/j.efsa.2005.241
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx	NOAEL	=50	mg/kg bw/day	Rat	oral: feed	-	reproduction toxicity	EFSA AFC - 2005 - OutputID 355 - development - teratogenic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBP) for use in food contact materials - doi:10.2903/j.efsa.2005.241

EPA_IRIS_iris_rfd_systems.csv 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EPA_IRIS_iris_rfd_systems.csv	NOAEL	=159	mg/kg/day	-	oral	chronic	IRIS chronic oral RfD system PoD	row_hash=7d7f70f33cb6993b; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.59e2 mg/kg-day; system=Hepatic; basis=Significantly increased liver-to-body weight and liver-to-brain weight ratios; point_of_departure=NOAEL : 1.59e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID3020205; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=293; rfd_last_updated=09/01/1989; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0293_summary.pdf
EPA_IRIS_iris_rfd_systems.csv	RfD	=0.2	mg/kg/day	-	oral	chronic	IRIS chronic oral RfD system	row_hash=093eace50a87a644; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-1; system=Hepatic; basis=Significantly increased liver-to-body weight and liver-to-brain weight ratios; point_of_departure=NOAEL : 1.59e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID3020205; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=293; rfd_last_updated=09/01/1989; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0293_summary.pdf

IARC Monographs 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
IARC Monographs	IARC carcinogenicity classification	3	IARC group	-	-	1998	IARC Monographs	{"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"Sup 7, 73"}

INCHEM_WHO_cicads_cicads_cicad17 27 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=1253	mg/kg bw/day	Rat	oral	90 days	Chronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=42889f714fdff2ea; raw_unit=mg/kg; context=Study protocol Effect level a Critical end-point/comments Reference Subchronic exposure Charles River rats LOAEL (males) = 1253 mg/kg Limited range of end-points, Hazleton (10/sex/group) body weight per day including body weight, food Laboratories, 1958 90 days NOEL (females) = 1270 mg/kg consumption, organ weight, and median intake body weight per day histopathological examination of in di
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=1250	mg/kg bw/day	Rat	-	13 weeks	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=b51a68411e599c40; raw_unit=mg/kg; context=0, 462, or 1270 mg/kg body weight F344/N rats LOAEL (males) = 1250 mg/kg body Histopathological degeneration of NTP, 1982 (10/sex/group) weight per day the testes and depressed weight 13 weeks NOEL = 625 mg/kg body weight gain.
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=1000	mg/kg bw/day	Rat	oral	14 days	Developmental toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=686168bd17add740; raw_unit=mg/kg body weight; context=kg body weight histopathology. per day Table 1 (continued) Study protocol Effect level a Critical end-point/comments Reference Reproductive/developmental studies RIVM-bred WU rats LOAEL = 1000 mg/kg body weight At top dose, reduction in body weight Piersma et al., (10/sex/group) per day gain, fluctuation in food consumption, 1995 14 days prior to and NOAEL = 500 mg/kg body weight reduction in weight of testis and throughout mating per day epididymis, and increase in
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=312.5	mg/kg bw/day	Rat	oral	14 days	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=de18f3bf33c7eed9; raw_unit=mg/kg body weight; context=Male F344 rats LOAEL = 312.5 mg/kg body weight Dose-related increases in relative Kluwe et al., 1984; (10/group) per day weights of kidney and liver at all Agarwal et al., 1985 14 days doses; increase in absolute kidney approximate intake in diet: weight at two lowest doses, and 0, 312.5, 625, 1250, or de
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=200	mg/kg bw/day	Rat	oral	10 weeks	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=a0989459b21c7b22; raw_unit=mg/kg body weight; context=ence Male F344/N rats NOEL = 20 mg/kg body weight Significant dose-related decrease in NTP, 1997a (15/group) per day epididymal spermatozoal concentration 10 weeks prior to mating LOAEL = 200 mg/kg body weight at the two highest dose levels. (modified mating protocol) per day Histopathological evidence of approximate intake in diet: (it should be noted that hypospermia and a decrease in fertility 0, 20, 200, or 2200 mg/kg dose spacing was poor in index were observe
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=1640	mg/kg bw/day	-	oral	-	Developmental toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=c8d893d3a7ebb4f7; raw_unit=mg/kg; context=Price et (30 females/group) = 420 mg/kg body weight per day fetuses with variations per litter. al., 1990 gestational days 6-15 LOAEL (significant maternal and Maternal toxicity was evident at the approximate intake in diet: minimal developmental effects) mid and high dose levels (decreased 0, 420, 1100, or 1640 mg/kg = 1100 mg/kg body weight per day maternal weight gain, increased body weight per day relative liver weight, increased food and water consumption).
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=2330	mg/kg bw/day	-	-	-	Developmental toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=bfb6ba4684438277; raw_unit=mg/kg; context=LOAEL (maternal and developmental) of live fetuses per litter, increased 0, 182, 910, or 2330 mg/kg = 910 mg/kg body weight per day percentage of litters with malformed body weight per day fetuses, and an increased percentage of malformed fetuses per litter.
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=654	mg/kg bw/day	Rat	oral	-	Developmental toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=98f85ae56d9cc49d; raw_unit=mg/kg; context=Table 1 (continued) Study protocol Effect level a Critical end-point/comments Reference Wistar rats (15-19 LOAEL (maternal) = 654 mg/kg Significant dose-related reduction Ema et al., 1990 females/group) body weight per day in maternal body weight gain and gestational days 0-20 NOEL (embryo/fetal toxicity) reduced food consumption at three approximate intake in = 654 mg/kg body weight per day
INCHEM_WHO_cicads_cicads_cicad17	LOAEL	=381	mg/kg bw	-	oral	Subchronic	Chronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=1b25294f91d47af2; raw_unit=mg/kg; context=Study Data for calculating Parameter estimates benchmark dose a (reference) Effect levels Dose Response Benchmark dose Goodness of fit Subchronic dietary LOAEL = 381 mg/kg body Males:
INCHEM_WHO_cicads_cicads_cicad17	LOEL	=171	mg/kg bw/day	-	-	-	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=650605730a1f7726; raw_unit=mg/kg body weight per day; context=The lowest-observed-effect level (LOEL) in females is 171 mg/kg body weight per day, based upon increases in organ to body weight ratio at all doses for the liver and caecum (the no-observed-effect level, or NOEL, in males is 151 mg/kg body weight per day).
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=180	mg/kg bw/day	Rat	oral	26 weeks	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=6e7384dd072e108e; raw_unit=mg/kg body weight; context=r day Male F344 rats LOEL = 550 mg/kg body weight Effects on haematological parameters NTP, 1997a (15/group) 26 weeks per day (significant increase in mean cell approximate intake NOAEL = 180 mg/kg body weight haemoglobin and mean cell in diet for four per day haemoglobin concentration) and lowest doses:
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=1852	mg/kg bw/day	Dog	oral	3 months	Subchronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=a14975fa0ef312cc; raw_unit=mg/kg; context=Beagle dogs (3 males NOAEL (males) = 1852 mg/kg Decreases in body weight gain at Hammond et al., 1987 and 3 females) body weight per day the highest doses associated with 3 months NOAEL (females) = 1973 mg/kg decreases in food consumption. approximate intake in body weight per day (Body weight increased bu
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=1973	mg/kg bw/day	Dog	oral	3 months	Subchronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=07af12b48c4c5721; raw_unit=mg/kg; context=Beagle dogs (3 males NOAEL (males) = 1852 mg/kg Decreases in body weight gain at Hammond et al., 1987 and 3 females) body weight per day the highest doses associated with 3 months NOAEL (females) = 1973 mg/kg decreases in food consumption. approximate intake in body weight per day (Body weight increased but remained diet or by capsule (highest doses administered) depressed in relation to controls (high-dose group): during 2 months of administration males:
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=500	mg/kg bw/day	Rat	oral	14 days	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=555defaab9b96ca0; raw_unit=mg/kg body weight; context=U rats LOAEL = 1000 mg/kg body weight At top dose, reduction in body weight Piersma et al., (10/sex/group) per day gain, fluctuation in food consumption, 1995 14 days prior to and NOAEL = 500 mg/kg body weight reduction in weight of testis and throughout mating per day epididymis, and increase in testicular (OECD 421 - combined degeneration (males).
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=418	mg/kg bw/day	-	oral	one-generation	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=d6ac7a8c8e4c9c40; raw_unit=mg/kg; context=No effects on reproductive performance 24 females per group) NOAEL (males) = 418 mg/kg body and development of offspring. one-generation reproductive weight per day TNO Biotechnology and study approximate intake NOAEL (females) = 446 mg/kg body Chemistry Institute, in diet: weight per day 1993 males:
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=446	mg/kg bw/day	-	oral	one-generation	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=fafefe071b465534; raw_unit=mg/kg; context=rmance 24 females per group) NOAEL (males) = 418 mg/kg body and development of offspring. one-generation reproductive weight per day TNO Biotechnology and study approximate intake NOAEL (females) = 446 mg/kg body Chemistry Institute, in diet: weight per day 1993 males:
INCHEM_WHO_cicads_cicads_cicad17	NOAEL	=217	mg/kg bw/day	-	oral	-	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=c6f848ea2dad4479; raw_unit=mg/kg; context=At top dose, significant increase in 446 mg/kg body weight NOEL (males) = 418 mg/kg body relative weight of livers and per day weight per day decrease in food consumption NOAEL (females) = 217 mg/kg and body weight (females). body weight per day LOEL (females) = 446 mg/kg body weight per day Examination of effects on Reduction in testes weight Dose-response was not investigated.
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=51	mg/m3	-	-	-	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=606e640924d41769; raw_unit=mg/m 3; context=The NOEL was 51 mg/m 3 .
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=1270	mg/kg bw/day	Rat	oral	90 days	Subchronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=9c97c888b51a3854; raw_unit=mg/kg; context=osure Charles River rats LOAEL (males) = 1253 mg/kg Limited range of end-points, Hazleton (10/sex/group) body weight per day including body weight, food Laboratories, 1958 90 days NOEL (females) = 1270 mg/kg consumption, organ weight, and median intake body weight per day histopathological examination of in diet: (highest doses administered) only seven organs/tissues, males:
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=625	mg/kg bw/day	Rat	-	13 weeks	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=c203efbede20e696; raw_unit=mg/kg body weight; context=70 mg/kg body weight F344/N rats LOAEL (males) = 1250 mg/kg body Histopathological degeneration of NTP, 1982 (10/sex/group) weight per day the testes and depressed weight 13 weeks NOEL = 625 mg/kg body weight gain.
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=375	mg/kg bw/day	Rat	-	3 months	Subchronic toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=1edeec33b2ea5f32; raw_unit=mg/kg; context=Sprague-Dawley rats LOEL (females) = 750 mg/kg Significant increases in liver to Hammond et al., 1987 (10/sex/group) body weight per day body weight ratio (females) and 3 months NOEL = 375 mg/kg body kidney to body weight ratio approximate intake in weight per day (males).
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=20	mg/kg bw/day	Rat	-	10 weeks	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=2c1a9adb28ef3d2e; raw_unit=mg/kg body weight; context=Table 1 (continued) Study protocol Effect level a Critical end-point/comments Reference Male F344/N rats NOEL = 20 mg/kg body weight Significant dose-related decrease in NTP, 1997a (15/group) per day epididymal spermatozoal concentration 10 weeks prior to mating LOAEL = 200 mg/kg body weight at the two highest dose levels. (modified mating protocol) per day Histopathological evidence of ap
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=418	mg/kg bw/day	-	oral	-	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=f85a46e8e8a9701a; raw_unit=mg/kg; context=At top dose, significant increase in 446 mg/kg body weight NOEL (males) = 418 mg/kg body relative weight of livers and per day weight per day decrease in food consumption NOAEL (females) = 217 mg/kg and body weight (females). body weight per day LOEL (females) = 446 mg/kg body weight per day Examination of effects on Reduction in testes weig
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=654	mg/kg bw/day	-	oral	-	Developmental toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=fa7a0eb0ca2252d5; raw_unit=mg/kg body weight per day; context=s (15-19 LOAEL (maternal) = 654 mg/kg Significant dose-related reduction Ema et al., 1990 females/group) body weight per day in maternal body weight gain and gestational days 0-20 NOEL (embryo/fetal toxicity) reduced food consumption at three approximate intake in = 654 mg/kg body weight per day highest doses (significant only at diet:
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=185	mg/kg bw/day	-	oral	-	Reproductive toxicity	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=58b67d8e09eefd3e; raw_unit=mg/kg body weight per day; context=n which effects (administration on days 0-20 in offspring were examined in study of unconventional design) following administration of (maternal LOEL) doses greater than 500 mg/kg NOEL (reproduction) = 185 mg/kg body weight per day either in body weight per day the diet or by gavage during various periods of gestation are not additionally informative with respect to effect levels.
INCHEM_WHO_cicads_cicads_cicad17	NOEL	=144	mg/m3	-	-	-	Toxicology study	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=c1567b2c4ec3af40; raw_unit=mg/m 3; context=For example, the NOEL in the investigation in which the range of end-points examined was more extensive (144 mg/m 3 ) is equivalent to a dose approximately threefold less than the point of departure (i.e., the 95% lower confidence limit) for the TDI presented above.
INCHEM_WHO_cicads_cicads_cicad17	TDI	=132	mg/kg bw/day	-	-	-	Health guidance value	document_id=cicads_cicads_cicad17; title=Butyl benzyl phthalate (CICADS); path=mirror/documents/cicads/cicads/cicad17.htm; row_hash=12b51fba03726d27; raw_unit=mg/kg body weight per day; context=TDI = 132 mg/kg body weight per day 100 = 1.3 mg/kg body weight per day where:

NTP_ICE_adme_parameters 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_adme_parameters	Clint	427	uL/min/10^6 cells	Human	-	-	Measured; httk, Human Hepatic Intrinsic Clearance	sheet=Data; excel_row=1128; Record_ID=adme_parameters_788; Data_Type=Measured; DTXSID=DTXSID3020205; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=427.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_adme_parameters	Clint	359	uL/min/10^6 cells	Rat	-	-	Measured; httk, Rat Hepatic Intrinsic Clearance	sheet=Data; excel_row=1129; Record_ID=adme_parameters_788; Data_Type=Measured; DTXSID=DTXSID3020205; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=359.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_adme_parameters	Fu	0.00000322	fraction	Human	-	-	Measured; httk, Human Plasma Fraction Unbound	sheet=Data; excel_row=1130; Record_ID=adme_parameters_788; Data_Type=Measured; DTXSID=DTXSID3020205; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=3.22e-06; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205

NTP_ICE_cancer 6 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_cancer	IARC group	3	unitless	-	-	-	WOE; IARC Carcinogenicity	sheet=Data; excel_row=3298; Record_ID=cancer_4506; Data_Type=WOE; Formulation_Name=Benzyl butyl phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_cancer	POLY-3 lowest dose	12000	ppm	Rat	Dosed feed	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=3307; Record_ID=cancer_4507; Data_Type=In Vivo; Formulation_Name=Butyl benzyl phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=12000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Pancreas; Location=Acinar Cell; Lesion=Carcinoma or adenoma; Reference=TR-458; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr458/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_cancer	POLY-3 lowest dose	24000	ppm	Rat	Dosed feed	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=3313; Record_ID=cancer_4509; Data_Type=In Vivo; Formulation_Name=Butyl benzyl phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=24000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Urinary bladder; Lesion=Carcinoma or papilloma; Reference=TR-458; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr458/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_cancer	Top dose	1.2	%	Rat	Dosed feed	-	In Vivo; NTP Carcinogenicity	sheet=Data; excel_row=3296; Record_ID=cancer_4507; Data_Type=In Vivo; Formulation_Name=Butyl benzyl phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1.2; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-213; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr213/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_cancer	Top dose	12000	ppm	Mouse	Dosed feed	-	In Vivo; NTP Carcinogenicity	sheet=Data; excel_row=3299; Record_ID=cancer_4505; Data_Type=In Vivo; Formulation_Name=Butyl benzyl phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=12000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-213; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr213/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_cancer	Top dose	2.4	%	Rat	Dosed feed	-	In Vivo; NTP Carcinogenicity	sheet=Data; excel_row=3315; Record_ID=cancer_4509; Data_Type=In Vivo; Formulation_Name=Butyl Benzyl Phthalate; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2.4; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-458; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr458/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205

NTP_ICE_endocrine 19 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_endocrine	AC50	12.9441187605648	uM	-	-	-	ERPathway2016; ER Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=5430; RecordID=ERPathway2016_205; DatasetName=ERPathway2016; DTXSID=DTXSID3020205; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=12.9441187605648; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	36000	nM	-	-	-	In Vitro; AR Binding	sheet=Data_invitro; excel_row=177; Record_ID=endocrine_invitro_171; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=36000; Reported_Response_Unit=nM; Response=36000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	2511.89	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13235; Record_ID=endocrine_invitro_2759; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2511.89; Reported_Response_Unit=nM; Response=2511.89; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	13000	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13263; Record_ID=endocrine_invitro_2006; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=13000; Reported_Response_Unit=nM; Response=13000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Krüger et al. 2008; 18294747; 10.1016/j.tox.2007.12.028; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	89200	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13500; Record_ID=endocrine_invitro_1892; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=89200; Reported_Response_Unit=nM; Response=89200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	101000	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13502; Record_ID=endocrine_invitro_2349; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=101000; Reported_Response_Unit=nM; Response=101000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Christen et al. 2010; 20943248; 10.1016/j.chemosphere.2010.09.031; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	AC50/EC50/IC50	4270	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13504; Record_ID=endocrine_invitro_1890; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4270; Reported_Response_Unit=nM; Response=4270; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Tamura et al. 2006; 16876421; 10.1016/j.bmc.2006.06.064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	ACC	7.41251839025667	uM	-	-	-	ERPathway2016; ER Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=5431; RecordID=ERPathway2016_205; DatasetName=ERPathway2016; DTXSID=DTXSID3020205; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=7.41251839025667; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	EC50	1980	nM	-	-	-	In Vitro; ER Transactivation-Agonist (VM7Luc Assay)	sheet=Data_invitro; excel_row=16610; Record_ID=endocrine_invitro_4444; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=ER Transactivation-Agonist (VM7Luc Assay); Endpoint=EC50; Reported_Response=1.9800000000000001E-6; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=1980; Converted_Response_Unit=nM; Response=1980; Response_Unit=nM; Reference=\|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	IC20	<1000	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13035; Record_ID=endocrine_invitro_2901; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=1000; Reported_Response_Unit=IC20 (nM); Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	IC20	>10000	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13036; Record_ID=endocrine_invitro_2895; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=10000; Reported_Response_Unit=IC20 (nM); Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	IC20	2900	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=13039; Record_ID=endocrine_invitro_1698; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=IC20; Reported_Response=2900; Reported_Response_Unit=IC20 (nM); Response=2900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	LEL	501.2	nM	-	-	-	In Vitro; AR Transactivation-Antagonist	sheet=Data_invitro; excel_row=14969; Record_ID=endocrine_invitro_1274; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=501.18700000000001; Reported_Response_Unit=nM; Response=501.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=5426; RecordID=ARPathway2016_1649; DatasetName=ARPathway2016; DTXSID=DTXSID3020205; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	Model Score	0.179	unitless	-	-	-	ERPathway2016; ER Pathway Model, Agonist	sheet=Integrated_approaches; excel_row=5432; RecordID=ERPathway2016_205; DatasetName=ERPathway2016; DTXSID=DTXSID3020205; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.179; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	NOEL	500	mg/kg bw/day	Rat	Oral	Treatment_Duration=10 days; Age_at_First_Dose=PND 49; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=7 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6	In Vivo; Hershberger-Antagonist	sheet=Data_invivo; excel_row=1570; Record_ID=endocrine_invivo_680; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=Hershberger-Antagonist; Endpoint=NOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Additional_Information=Browne et al. 2018 unique record identifier 51; Reference=Lee and Koo 2007; 17654256; 10.1080/15287390701432285\|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	PC50	4110	nM	-	-	-	In Vitro; ER Transactivation-Agonist (STTA Assay)	sheet=Data_invitro; excel_row=16514; Record_ID=endocrine_invitro_4444; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=ER Transactivation-Agonist (STTA Assay); Endpoint=PC50; Reported_Response=4.1099999999999996E-6; Reported_Response_Unit=M; Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=4109.99999999999; Converted_Response_Unit=nM; Response=4110; Response_Unit=nM; Reference=\|OECD TG 455; https://www.oecd.org/env/test-no-455-performance-based-test-guideline-for-stably-transfected-transactivation-in-vitro-assays-to-detect-estrogen-receptor-9789264265295-en.htm; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	RBA	0.008511	unitless	-	-	-	In Vitro; AR Binding	sheet=Data_invitro; excel_row=1973; Record_ID=endocrine_invitro_1127; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Binding; Endpoint=RBA; Reported_Response=-2.0699999999999998; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=8.5113803820239566E-3; Converted_Response_Unit=Unitless; Response=0.008511; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Hong et al. 2003; 14758981; 10.1080/10629360310001623962; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_endocrine	RBA	0.0085	unitless	-	-	-	In Vitro; AR Binding	sheet=Data_invitro; excel_row=2642; Record_ID=endocrine_invitro_171; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=AR Binding; Endpoint=RBA; Reported_Response=8.5000000000000006E-3; Reported_Response_Unit=Unitless; Response=0.0085; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347\|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205

NTP_ICE_skin_sensitization 6 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_skin_sensitization	CV75	1000	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; h-CLAT	sheet=Data_invitro; excel_row=1664; Record_ID=skin_sensitization_invitro_458; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_skin_sensitization	Depletion Cys	3.6	%	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; DPRA	sheet=Data_invitro; excel_row=98; Record_ID=skin_sensitization_invitro_29; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.6; Reported_Response_Unit=%; Response=3.6; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_skin_sensitization	Depletion Lys	0.1	%	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; DPRA	sheet=Data_invitro; excel_row=115; Record_ID=skin_sensitization_invitro_29; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.1; Reported_Response_Unit=%; Response=0.1; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_skin_sensitization	EC1.5	9.834	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; KeratinoSens	sheet=Data_invitro; excel_row=6874; Record_ID=skin_sensitization_invitro_1627; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.83390188; Reported_Response_Unit=uM; Response=9.834; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_skin_sensitization	IC50	4000	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; KeratinoSens	sheet=Data_invitro; excel_row=6877; Record_ID=skin_sensitization_invitro_1627; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205
NTP_ICE_skin_sensitization	Imax	2.992	ratio	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; KeratinoSens	sheet=Data_invitro; excel_row=6879; Record_ID=skin_sensitization_invitro_1627; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3020205; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.992304791; Reported_Response_Unit=Unitless; Response=2.992; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020205; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020205

ToxRefDB_ToxRefDB_v3_pod.csv 14 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxRefDB_ToxRefDB_v3_pod.csv	LEL	>1250	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 91 day	SUB	study_id=6406; toxval_study_source_id=studyid6406_Adult_F0_F_NA; dose_level=5; study_year=1982; study_citation=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Subchronic Rat); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LEL	=300	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6408; toxval_study_source_id=studyid6408_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight\|in life observation-food consumption-food consumption\|pathology microscopic-spleen-congestion\|pathology gross-liver-irregular surface\|pathology gross-spleen-irregular surface\|pathology gross-full gross necropsy-leukemia mononuclear; dose_level=1; study_year=1982; study_citation=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Chronic Rat); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LEL	=900	mg/kg bw/day	mouse (b6c3f1; B6C3F1)	oral	0 day to 2 year	CHR	study_id=6409; toxval_study_source_id=studyid6409_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1982; study_citation=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Chronic Mouse); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LEL	=180	mg/kg bw/day	rat (fischer; Fischer 344/N)	oral	0 day to 26 week	SUB	study_id=6535; toxval_study_source_id=studyid6535_Adult_F0_M_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)\|pathology microscopic-testes-hypospermia\|organ weight-epididymis-absolute\|pathology gross-sperm measure-sperm count\|pathology microscopic-epididymis-hypospermia\|in life observation-body weight-body weight gain\|in life observation-body weight-body weight\|hematology-hematocrit (hct)-hematocrit (hct)\|organ weight-testes-relative to body weight\|pathology microscopic-testes-atrophy\|hematology-reticulocyte-reticulocyte\|hematology-anemia-anemia - macrocytic\|organ weight-testes-absolute; dose_level=3; study_year=1997; study_citation=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LEL	=120	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6538; toxval_study_source_id=studyid6538_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight\|pathology microscopic-prostate-corpora amylacea\|pathology microscopic-skin-hyperkeratosis\|pathology microscopic-kidney-pigmentation\|pathology microscopic-pancreas-hyperplasia\|pathology microscopic-liver-granuloma\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|pathology microscopic-pancreas-adenoma/carcinoma combined\|pathology microscopic-skin-acanthosis\|pathology microscopic-pancreas-adenoma\|in life observation-body weight-body weight; dose_level=1; study_year=1997; study_citation=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LOAEL	=1250	mg/kg bw/day	rat (fischer; Fischer 344/N)	oral	0 day to 26 week	SUB	study_id=6535; toxval_study_source_id=studyid6535_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-testes-hypospermia\|organ weight-epididymis-absolute\|pathology gross-sperm measure-sperm count\|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|pathology microscopic-epididymis-hypospermia\|in life observation-body weight-body weight gain\|in life observation-body weight-body weight\|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)\|hematology-hematocrit (hct)-hematocrit (hct)\|organ weight-testes-relative to body weight\|pathology microscopic-testes-atrophy\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-reticulocyte-reticulocyte\|hematology-anemia-anemia - macrocytic\|organ weight-testes-absolute; dose_level=5; study_year=1997; study_citation=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LOAEL	=1200	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6538; toxval_study_source_id=studyid6538_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-urinary bladder-hyperplasia\|in life observation-body weight-body weight; dose_level=3; study_year=1997; study_citation=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	LOAEL	=500	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6538; toxval_study_source_id=studyid6538_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-pancreas-hyperplasia\|in life observation-body weight-body weight; dose_level=3; study_year=1997; study_citation=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NEL	=625	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 91 day	SUB	study_id=6406; toxval_study_source_id=studyid6406_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight\|in life observation-body weight-body weight gain\|pathology microscopic-testes-degeneration; dose_level=4; study_year=1982; study_citation=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Subchronic Rat); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NEL	>0	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6408; toxval_study_source_id=studyid6408_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption\|pathology gross-spleen-irregular surface\|pathology gross-liver-irregular surface\|pathology microscopic-spleen-congestion\|pathology gross-full gross necropsy-leukemia mononuclear\|in life observation-body weight-body weight; dose_level=0; study_year=1982; study_citation=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Chronic Rat); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NEL	=60	mg/kg bw/day	rat (fischer; Fischer 344/N)	oral	0 day to 26 week	SUB	study_id=6535; toxval_study_source_id=studyid6535_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-epididymis-hypospermia\|in life observation-body weight-body weight gain\|in life observation-body weight-body weight\|pathology gross-sperm measure-sperm count\|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|organ weight-epididymis-absolute\|pathology microscopic-testes-hypospermia\|organ weight-testes-absolute\|organ weight-testes-relative to body weight\|pathology microscopic-testes-atrophy\|hematology-anemia-anemia - macrocytic\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-reticulocyte-reticulocyte\|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)\|hematology-hematocrit (hct)-hematocrit (hct); dose_level=2; study_year=1997; study_citation=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NOAEL	=550	mg/kg bw/day	rat (fischer; Fischer 344/N)	oral	0 day to 26 week	SUB	study_id=6535; toxval_study_source_id=studyid6535_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain\|in life observation-body weight-body weight\|pathology microscopic-epididymis-hypospermia\|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|pathology gross-sperm measure-sperm count\|organ weight-epididymis-absolute\|pathology microscopic-testes-hypospermia\|organ weight-testes-absolute\|hematology-anemia-anemia - macrocytic\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-reticulocyte-reticulocyte\|organ weight-testes-relative to body weight\|pathology microscopic-testes-atrophy\|hematology-hematocrit (hct)-hematocrit (hct)\|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=4; study_year=1997; study_citation=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NOAEL	=600	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6538; toxval_study_source_id=studyid6538_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-urinary bladder-papilloma\|pathology microscopic-kidney-pigmentation\|pathology microscopic-urinary bladder-hyperplasia\|pathology microscopic-kidney-nephropathy\|in life observation-body weight-body weight\|clinical chemistry-triiodothyronine (t3)-triiodothyronine (t3), total\|organ weight-kidney-relative to body weight\|hematology-hematocrit (hct)-hematocrit (hct)\|pathology microscopic-pancreas-adenoma; dose_level=2; study_year=1997; study_citation=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv	NOAEL	=240	mg/kg bw/day	rat (fischer; Fischer 344)	oral	0 day to 2 year	CHR	study_id=6538; toxval_study_source_id=studyid6538_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-hyperkeratosis\|organ weight-kidney-relative to body weight\|pathology microscopic-prostate-corpora amylacea\|pathology microscopic-kidney-pigmentation\|pathology microscopic-pancreas-hyperplasia\|pathology microscopic-liver-granuloma\|pathology microscopic-skin-acanthosis\|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|pathology microscopic-pancreas-adenoma/carcinoma combined\|pathology microscopic-pancreas-adenoma\|in life observation-body weight-body weight; dose_level=2; study_year=1997; study_citation=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); dsstox_substance_id=DTXSID3020205; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5

ToxValDB_Alaska_DEC 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_Alaska_DEC	RfD	=0.122	mg/kg bw/day	Human	dermal	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446187:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=4397aa4abbbacace5a004999b5124f57
ToxValDB_Alaska_DEC	RfD	=0.2	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446188:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1bca68c2c8a822cd53c9d6dacb1b0a99
ToxValDB_Alaska_DEC	RfD	=0.122	mg/kg bw/day	Human	dermal	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446187:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=4397aa4abbbacace5a004999b5124f57
ToxValDB_Alaska_DEC	RfD	=0.2	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446188:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=1bca68c2c8a822cd53c9d6dacb1b0a99

ToxValDB_DOE_Protective_Action_Criteria 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_DOE_Protective_Action_Criteria	LEL	=153309	mg/m3	Human	inhalation	-	acute	LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15518519:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71ac2f0e61e409db652f410f32e014bd

ToxValDB_ECHA_IUCLID 16 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECHA_IUCLID	NOAEC	=218	mg/m3	Rat	inhalation	acute; 6 hours	acute	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/6/3?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827382_15827508:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd3539b6975f221abe0a2753b4f27b34
ToxValDB_ECHA_IUCLID	NOAEC	=1000	mg/m3	Rat	inhalation	acute; 6 hours	acute	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/6/3?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827382_15827508:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6e0058e374f7074382dc25f8bb16430
ToxValDB_ECHA_IUCLID	NOAEL	=1500	mg/kg bw/day	Rat	oral	-	repeat dose other	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f44; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/10/1?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825779_15825780_15825781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33ffbfae88fdc934147ccfe2d92a7d57
ToxValDB_ECHA_IUCLID	NOAEL	=3000	mg/kg bw/day	Rat	oral	-	repeat dose other	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f44; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/10/1?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825779_15825780_15825781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41044eaa3bf21f8147cc92d638b0b89c
ToxValDB_ECHA_IUCLID	NOAEL	=500	mg/kg bw/day	Rat	oral	-	repeat dose other	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4f44; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/10/1?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825779_15825780_15825781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bce73a646e87d42e34964a15818c83a2
ToxValDB_ECHA_IUCLID	NOAEL	~151	mg/kg bw/day	Rat	oral	chronic; 109 days	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf24e4b0a7c65d1ccc13; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/6/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15839694:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a098363f9a79ad12da321bbabe4115d
ToxValDB_ECHA_IUCLID	NOAEL	~780	mg/kg bw/day	Mouse	oral	chronic; 103 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf24e4b0a7c65d1ccc16; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/6/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15839712:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44bdf5ce660472696755418b6b708796
ToxValDB_ECHA_IUCLID	NOAEL	=550	mg/kg bw/day	Rat	oral	chronic; 26 weeks	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf24e4b0a7c65d1ccc1d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/6/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15842210:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ba3f1bcc86ad9262da3a5b8efdef5b8
ToxValDB_ECHA_IUCLID	NOAEL	~250	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab76e4b0a7c65d1ba546; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/9/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15855395:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f69a1871aa7f5fd93237eb2dd11f3435
ToxValDB_ECHA_IUCLID	NOAEL	~100	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba550; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/9/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858351_15858758:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a881317d1b1d7f3903bb524bc079f2f
ToxValDB_ECHA_IUCLID	NOAEL	~20	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba550; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/9/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858351_15858758:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11dcd29fb494a34b21811a20dce6608e
ToxValDB_ECHA_IUCLID	NOEL	~240	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b4860; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/8?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15816293:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4dcd4e2d38f1bd97a46ef86663cb66fa
ToxValDB_ECHA_IUCLID	NOEL	~600	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b4860; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/8?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816294_15817605:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83a1eca5885a34b814575e108412545a
ToxValDB_ECHA_IUCLID	NOEL	~300	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b4862; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/8?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816294_15817605:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4412019a52a41c7d9aea35de8f62d2a8
ToxValDB_ECHA_IUCLID	NOEL	~1560	mg/kg bw/day	Mouse	oral	-	chronic	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa26e4b0a7c65d1b4866; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/8?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15818329:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6871c468fb1e96a7b530b248a4fca25c
ToxValDB_ECHA_IUCLID	NOEL	~50	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab76e4b0a7c65d1ba546; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12721/7/9/2?documentUUID=acaecb5d-ce3e-4be3-b594-dc933f34578c; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=ECHA IUCLID:15856216:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a0078b5262105287f8d48bd9cef3641

ToxValDB_ECOTOX 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECOTOX	LOEL	=1000	mg/kg bw/day	Rat	oral	short-term; 4 days	short-term	LONG_REF=Toxicol. Lett.146(3): 207-215 Wilson,V.S., C. Lambright, J. Furr, J. Ostby, C. Wood, G. Held, and L.E.,Jr. Gray Phthalate Ester-Induced Gubernacular Lesions are Associated with Reduced ins13 Gene Expression in the Fetal Rat Testis 2004; TITLE=Phthalate Ester-Induced Gubernacular Lesions are Associated with Reduced ins13 Gene Expression in the Fetal Rat Testis; AUTHOR=Wilson,V.S., C. Lambright, J. Furr, J. Ostby, C. Wood, G. Held, and L.E.,Jr. Gray; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=95506; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Male fetus: Genetics: Insl3 (insulin-like peptide 3) mRNA\|Male fetus: Hormone(s): Testosterone; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599180_15599181:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4d2d6481efd11a59613d409698cbc2f9
ToxValDB_ECOTOX	LOEL	=200	mg/kg bw/day	Mouse	injection	short-term; 19 days	short-term	LONG_REF=Food Chem. Toxicol.41(3): 439-446 Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model 2003; TITLE=Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model; AUTHOR=Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen; DOI=10.1016/s0278-6915(02)00248-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Immunological: immunoglobulin E; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597249_15608816_15608817:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2e2df24367fe0908ee89f189cf05cbff
ToxValDB_ECOTOX	LOEL	=500	mg/kg bw/day	Rat	oral	short-term (developmental); 5 days	reproduction developmental	LONG_REF=Biol. Reprod.71:1852-1861 Hotchkiss,A.K., L.G. Parks-Saldutti, J.S. Ostby, C. Lambright, J. Furr, J.G. Vandenbergh, and L.E.,Jr. Gray A Mixture of the \"Antiandrogens\" Linuron and Butyl Benzyl Phthalate Alters Sexual Differentiation of the Male Rat in a Cumulative Fashion 2004; TITLE=A Mixture of the "Antiandrogens" Linuron and Butyl Benzyl Phthalate Alters Sexual Differentiation of the Male Rat in a Cumulative Fashion; AUTHOR=Hotchkiss,A.K., L.G. Parks-Saldutti, J.S. Ostby, C. Lambright, J. Furr, J.G. Vandenbergh, and L.E.,Jr. Gray; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=190714; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Hormone(s): Progesterone\|Hormone(s): Testosterone\|Morphology: Length\|Morphology: Weight\|Physiology: Hydronephrosis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry\|gross pathology\|other; STUDY_GROUP=ECOTOX:15612745:M:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=bbbcef9392cb62e4570291aa4a8afade
ToxValDB_ECOTOX	NOEL	=2000	mg/kg bw/day	Mouse	injection	short-term; 19 days	short-term	LONG_REF=Food Chem. Toxicol.41(3): 439-446 Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model 2003; TITLE=Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model; AUTHOR=Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen; DOI=10.1016/s0278-6915(02)00248-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Immunological: immunoglobulin E\|Immunological: Immunoglobulin G; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry\|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597249_15608816_15608817:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4341345406f0360159fe0e0978bdb449
ToxValDB_ECOTOX	NOEL	=20	mg/kg bw/day	Mouse	injection	short-term; 19 days	short-term	LONG_REF=Food Chem. Toxicol.41(3): 439-446 Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model 2003; TITLE=Investigation of the Adjuvant and Immuno-Suppressive Effects of Benzyl Butyl Phthalate, Phthalic Acid and Benzyl Alcohol in a Murine Injection Model; AUTHOR=Larsen,S.T., R.M. Lund, P. Thygesen, O.M. Poulsen, and G.D. Nielsen; DOI=10.1016/s0278-6915(02)00248-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Immunological: immunoglobulin E; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597249_15608816_15608817:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=151f95a22ac26af1454286913f3c84e7

ToxValDB_EFSA 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_EFSA	NOAEL	=50	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=EFSA AFC (2005). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBP) for use in food contact materials. doi:10.2903/j.efsa.2005.241.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to Butylbenzylphthalate (BBP) for use in food contact materials; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2005.241; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15614261:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4c1a73f7d5aa5936d3c4c440645d61d

ToxValDB_EPA_TSCA_8e 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_EPA_TSCA_8e	NEL	=1	mg/L	Rat	oral	subchronic (developmental)	reproduction developmental	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88950000291_85687_33A5DB29721A6A4685256930004D6695.pdf; TOXICOLOGICAL_EFFECT=F1: no developmental effects observed in male offspring; STUDY_GROUP=EPA TSCA 8e_dup_-_15956832_15956835_15956846_15956847:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_51c7cc37cfc7fa24ac3d4eff24f154cf
ToxValDB_EPA_TSCA_8e	NOEL	=750	ppm	Rat	oral	subchronic (developmental)	reproduction developmental	GUIDELINE=OPPTS 870.3800 (OECD 416) - Reproduction and Fertility Effects; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89020000082_85687_96F12E9E796017808525702F006FE140.pdf; YEAR=2000-2001; ORIGINAL_YEAR=2000-2001; TOXICOLOGICAL_EFFECT=P0: no reproductive toxicity effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15956829_15956830_15956831_15956837_15956842_15956843_15956844_15956845:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_678493397536f8fdc3606d6f092ed883
ToxValDB_EPA_TSCA_8e	NOEL	=3750	ppm	Rat	oral	subchronic (developmental)	reproduction developmental	GUIDELINE=OPPTS 870.3800 (OECD 416) - Reproduction and Fertility Effects; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89020000082_85687_96F12E9E796017808525702F006FE140.pdf; YEAR=2000-2001; ORIGINAL_YEAR=2000-2001; TOXICOLOGICAL_EFFECT=F1: no reproductive toxicity effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15956829_15956830_15956831_15956837_15956842_15956843_15956844_15956845:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73f065f19dc4ab467258e651587f511c
ToxValDB_EPA_TSCA_8e	NOEL	=11250	ppm	Rat	oral	subchronic (developmental)	reproduction developmental	GUIDELINE=OPPTS 870.3800 (OECD 416) - Reproduction and Fertility Effects; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/89020000082_85687_96F12E9E796017808525702F006FE140.pdf; YEAR=2000-2001; ORIGINAL_YEAR=2000-2001; TOXICOLOGICAL_EFFECT=F2: no reproductive toxicity effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15956829_15956830_15956831_15956837_15956842_15956843_15956844_15956845:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a050e394e41f7b48d842193f465c443c

ToxValDB_GESTIS_DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_GESTIS_DNEL	DNEL systemic	=4.36	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630061:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdb6a9ca8fcccac9baaf416cd782151f

ToxValDB_HAWC_Project 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_HAWC_Project	LOEL	=0.18	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=Ashby J et al. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul. Toxicol. Pharmacol. 1997; 26 (1 Pt 1):102-18.; TITLE=Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning.; AUTHOR=Ashby J, Tinwell H, Lefevre PA, Odum J, Paton D, Millward SW, Tittensor S, Brooks AN; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/351/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/23355/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=F1: AGD (mm); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=HAWC Project:15636526:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9be00d0ed377f46a52cb7c4d41130f67
ToxValDB_HAWC_Project	NOEL	=400	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=Aso S et al. A two-generation reproductive toxicity study of butyl benzyl phthalate in rats. J Toxicol Sci 2005; 30 Spec No. ():39-58.; TITLE=A two-generation reproductive toxicity study of butyl benzyl phthalate in rats.; AUTHOR=Aso S, Ehara H, Miyata K, Hosyuyama S, Shiraishi K, Umano T, Minobe Y; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/351/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/23499/ \|::\| https://hawcproject.org/ani/endpoint/23505/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=F1: AGD (mm)\|F1: AGD (mm/cube root BW); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=HAWC Project:15636094:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7630ddf3a200cf0176329f074ed3d492
ToxValDB_HAWC_Project	NOEL	=100	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=Ahmad R et al. Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat. Environ Sci Pollut Res Int 2014; 21 (4):3156-65.; TITLE=Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat.; AUTHOR=Ahmad R, Gautam AK, Verma Y, Sedha S, Kumar S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/351/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/23786/ \|::\| https://hawcproject.org/ani/endpoint/23787/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=F1: AGD (units not specified); TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=HAWC Project:15636097:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1861c611d6d884d75ffd943323d7c2b2

ToxValDB_HPVIS 29 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_HPVIS	LOAEL	=540	mg/kg bw/day	Rat	oral	short-term; 28 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.BIBRA Report No 112/2/92. June 1992; EXTERNAL_SOURCE_ID=60565; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS:15639620:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d179ab6d4210f5769723944d5003d9d8
ToxValDB_HPVIS	LOAEL	=639	mg/kg bw/day	Rat	oral	short-term; 21 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Barber, E.D. et al., Peroxisome induction studies phthalate esters, (1987) Toxicology and Industria 3,7-24.Monsanto study BB-86-9045; EXTERNAL_SOURCE_ID=61082; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15639699:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5aa42624927a54e3bbcc75b08aed2b2
ToxValDB_HPVIS	LOAEL	=224	mg/kg bw/day	Mouse	oral	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.National Toxicology Program, Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3Fl Mice (Feed Study), NTP-80-25, NIH Publication No. 82-1769, U.S. Department of Health and Human Services (1082).; EXTERNAL_SOURCE_ID=62377; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT_CATEGORY=-\|body weight; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639884_15639885:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e8c5829e7214de08eb7ca469fc52a06e
ToxValDB_HPVIS	LOAEL	=360	mg/kg bw/day	Rat	oral	chronic; 365 days	chronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsanto study XX-91-0062; EXTERNAL_SOURCE_ID=63705; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT_CATEGORY=-\|enzyme activity; STUDY_GROUP=HPVIS:15640066:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f16b20f87fbcc770e1702f138833933
ToxValDB_HPVIS	NOAEL	=480	mg/kg bw/day	Rat	oral	short-term; 14 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond,B.G., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (10871, A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.; EXTERNAL_SOURCE_ID=60564; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639619:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d596939d14e2bee6f640d04e398a3372
ToxValDB_HPVIS	NOAEL	=500	mg/kg bw/day	Dog	oral	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond, B.G.(1981) Toxicology of butyl benzyl pphthalate, Toxicologist 1,114.Hammond,B.G., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (10871, A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.; EXTERNAL_SOURCE_ID=61081; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639698:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2165f095563edee623f105a0ce74014e
ToxValDB_HPVIS	NOAEL	>5250	mg/kg bw/day	Mouse	oral	short-term; 14 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.National Toxicology Program, Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3Fl Mice (Feed Study), NTP-80-25, NIH Publication No. 82-1769, U.S. Department of Health and Human Services (1082).; EXTERNAL_SOURCE_ID=61639; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=HPVIS:15639775:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96fb92d763a057b5c8b0ee2cbc3affb7
ToxValDB_HPVIS	NOAEL	=1	mg/L	Rat	inhalation	short-term; 28 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsanto study ML-79-0016Hammond,B.C., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (1087), A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicoloqy and Industrial Health 3,79-98.Roloff, M.V., et al., Toxicologist (1983) 3, 24.; EXTERNAL_SOURCE_ID=61881; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639810_15640065:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_421e5084be02fec8794af175efa3304b
ToxValDB_HPVIS	NOAEL	=0.218	mg/L	Rat	inhalation	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsanto study ML-79-0144Hammond,B.C., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (1087), A Review of the Subchronic Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.Roloff, M.V., et al., Toxicologist (1983) 3, 24.; EXTERNAL_SOURCE_ID=62134; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=HPVIS:15639849:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4de7f76117489a00ff9dd5843223417f
ToxValDB_HPVIS	NOAEL	=160	mg/kg bw/day	Rat	oral	short-term; 14 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond,B.G., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (10871, A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.; EXTERNAL_SOURCE_ID=62375; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639883:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af752b27ea27628b30a7d0079408ccc0
ToxValDB_HPVIS	NOAEL	=882	mg/kg bw/day	Mouse	oral	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.National Toxicology Program, Carcinogenesis Bioassay of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats and B6C3Fl Mice (Feed Study), NTP-80-25, NIH Publication No. 82-1769, U.S. Department of Health and Human Services (1082).; EXTERNAL_SOURCE_ID=62376; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639884_15639885:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_312644f82e63a9931f2d633dff32486f
ToxValDB_HPVIS	NOAEL	=375	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond,B.G., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (10871, A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.; EXTERNAL_SOURCE_ID=62378; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15639886:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_458af42ae14e3e0ffca19d56b7e751b4
ToxValDB_HPVIS	NOAEL	=470	mg/kg bw/day	Rat	oral	chronic; 182 days	chronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hazleton Laboratories America Inc. (1985). Report submitted to the National Toxicology Program. Project Number 12307-02,3.; EXTERNAL_SOURCE_ID=62931; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=HPVIS:15639954:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e41e7d1186d07a799b14e97e3d60fb4b
ToxValDB_HPVIS	NOAEL	=151	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond,B.G., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (10871, A Review of the Subchronoc Toxicity of Butyl Benzyl Phthalate, Toxicology and Industrial Health 3,79-98.; EXTERNAL_SOURCE_ID=63447; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=HPVIS:15640025:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b3ecf89c14559a97f45697ce390e525
ToxValDB_HPVIS	NOAEL	=0.144	mg/L	Rat	inhalation	short-term; 28 days	short-term	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hammond,B.C., Levinskas,G.J., Robinson,E.C., and Johannsen,F.R. (1087), A Review of the Subchronic of Butyl Benzyl Phthalate, Toxicology and Industrial health 3,79-98.; EXTERNAL_SOURCE_ID=63704; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639810_15640065:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47804f79d04eee464b37804e70bd2738
ToxValDB_HPVIS	NOAEL	=10	mg/kg bw/day	Rabbit	oral	short-term; 12 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsanto Study BT-76-187; EXTERNAL_SOURCE_ID=57886; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=HPVIS:15642286:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d0b1aabed99d002b46509b58e21fd7d7
ToxValDB_HPVIS	NOAEL	=314	mg/kg bw/day	Rat	oral	short-term; 20 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Ema,M., Itami,T., and Kawaski,H. (1990). Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats. J.Appl,Toxicol. 10:339-343.; EXTERNAL_SOURCE_ID=58235; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642391_15642885:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e484152fb38a04b9f8f406433e9ef650
ToxValDB_HPVIS	NOAEL	=600	mg/kg bw/day	Rat	oral	-	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Ema,M. et al., Toxicology (1993) 79,11-19.; EXTERNAL_SOURCE_ID=58241; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642394_15642652_15642887:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f135df63f52372ad204bdcd991ef7639
ToxValDB_HPVIS	NOAEL	=420	mg/kg bw/day	Rat	oral	short-term; 10 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Price, C.J. Field, E.A. Marr, M.C., Mayer, C.B., Morrissey, R.E. and Schwetz, B.A., (1990) Decelopmental toxicity of butyl benzyl phthalate (BBP) in mice and rats. Teratology 41:586 (Abstract-P51)Price, C.J., Field, E.A., Marr, M.C., Mayers, C.B., Morrissey, R.E., Schwetz,B.A., and Heindel, J.J. (June 22,199O). Final Report on the Developmental Toxicity of Butyl Benzyl Phthalate (CAS No. 85-68-7) in CD-l Swiss mice.NTP/NIEHS, Research Triangle Park,NC,NTP Report #90-144.; EXTERNAL_SOURCE_ID=59035; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642647:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b560c98200e7d4484dde1ba520fe2d17
ToxValDB_HPVIS	NOAEL	>1018	mg/kg bw/day	Rat	oral	short-term; 20 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Ema,M., Itami,T., and Kawaski,H. (1990). Evaluation of the teratogenic potential of the plasticizer butyl benzyl phthalate in rats. J.Appl,Toxicol. 10:339-343.; EXTERNAL_SOURCE_ID=59036; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS:15642648:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0eb6dcde6a7517b2b321e9d241205728
ToxValDB_HPVIS	NOAEL	<631	mg/kg bw/day	Rat	oral	-	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Ema,M et al., (1992) Journal of Applied Toxicology 12, 179-183.; EXTERNAL_SOURCE_ID=59043; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642394_15642652_15642887:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21dbcea5a01d18874abd36dd92e9b473
ToxValDB_HPVIS	NOAEL	=1100	mg/kg bw/day	Rat	oral	short-term; 10 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Price, C.J. Field, E.A. Marr, M.C., Mayer, C.B., Morrissey, R.E. and Schwetz, B.A., (1990) Decelopmental toxicity of butyl benzyl phthalate (BBP) in mice and rats. Teratology 41:586 (Abstract-P51)Price, C.J., Field, E.A., Marr, M.C., Mayers, C.B., Morrissey, R.E., Schwetz,B.A., and Heindel, J.J. (June 22,199O). Final Report on the Developmental Toxicity of Butyl Benzyl Phthalate (CAS No. 85-68-7) in CD-l Swiss mice.NTP/NIEHS, Research Triangle Park,NC,NTP Report #90-144.; EXTERNAL_SOURCE_ID=59837; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642881:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42a31f5f087b1c1ce2594e33852d52b5
ToxValDB_HPVIS	NOAEL	<1087	mg/kg bw/day	Rat	oral	short-term; 20 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Emma,M. et a1.,(1991) Journal of Applied Toxicology 11,39-42.; EXTERNAL_SOURCE_ID=59841; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642391_15642885:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4833c62a7d882032278a99f64493dc1b
ToxValDB_HPVIS	NOAEL	<824	mg/kg bw/day	Rat	oral	-	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Ema,M. et al., (1992) Journal of Applied Toxicology 12,57-61 (1992); EXTERNAL_SOURCE_ID=59842; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642886_15642888:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72c8870e675894ccf16f03782fe44f90
ToxValDB_HPVIS	NOAEL	=418	mg/kg bw/day	Rat	oral	-	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsant Report Xx-93-9101(TN0 Report v92.570); EXTERNAL_SOURCE_ID=65168; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15643133:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac3b340d69b9f5791de966823b1d47ce
ToxValDB_HPVIS	NOAEL	=168	mg/kg bw/day	Rat	oral	chronic; 26 weeks	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hazleton Laboratories America Inc. (1985). Report submitted to the National Toxicology Program. Project Number 12307-02,3.; EXTERNAL_SOURCE_ID=65169; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15643134:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ddf855669cf9c3ba48978c9f3aeb6158
ToxValDB_HPVIS	NOAEL	=498	mg/kg bw/day	Rat	oral	chronic; 26 weeks	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Hazleton Laboratories America Inc. (1985). Report submitted to the National Toxicology Program. Project Number 12307-02,3.; EXTERNAL_SOURCE_ID=65768; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15643315:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0b66c0795ce91275225fd7c8281e5e4
ToxValDB_HPVIS	NOAEL	=206	mg/kg bw/day	Rat	oral	-	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.Monsant Report Xx-93-9101(TN0 Report v92.570); EXTERNAL_SOURCE_ID=66042; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15643383:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3d62b69bd5d80e7598a5ba66674798a8
ToxValDB_HPVIS	NOAEL	<=679	mg/kg bw/day	Rat	oral	short-term; 21 days	reproduction developmental	LONG_REF=Data from this HPVIS summary were extracted from documents posted to the HPV Challenge website on March 15, 2002.British Industrial Biological Research Association (BIBRA, 1985). A 21- day feeding study of butyl benzyl phthalate to rats: effects on the liver and liver lipids. Report Number 0495/l/84.; EXTERNAL_SOURCE_ID=66048; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS:15643385:-:F0parental; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fd1588c20876b9488de18cff194275d

ToxValDB_IRIS 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_IRIS	NOAEL	=159	mg/kg bw/day	Rat	oral	chronic; 26 weeks	chronic	LONG_REF=NTP (National Toxicology Program). 1985. Twenty-six week subchronic study and modified mating trial in F344 rats. Butyl benzyl phthalate. Final Report. Project No. 12307-02, -03. Hazelton Laboratories America, Inc. Unpublished study.; TITLE=Twenty-six week subchronic study and modified mating trial in F344 rats. Butyl benzyl phthalate. Final Report; AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5467; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=293; TOXICOLOGICAL_EFFECT=increased liver-to-body weight and liver-to-brain weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644810_15644811:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_976546e478b8f7798f028a913132b6f7

ToxValDB_RSL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_RSL	RfD	=2	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663716:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78113220b3adf9d2c0a735aa635aaef2

ToxValDB_ToxRefDB 8 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ToxRefDB	LEL	>1250	mg/kg bw/day	Rat	oral	chronic; 91 days	chronic	LONG_REF=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6406; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ToxRefDB_dup_-_15711634_15711635_15711636_15711637:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b451fcd35749b2af7ac179cf554ed571
ToxValDB_ToxRefDB	LEL	=900	mg/kg bw/day	Mouse	oral	chronic; 2 years	chronic	LONG_REF=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Chronic Mouse); TITLE=CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6409; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15711644_15711645:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a277857329ad6ee5733c37c3473c086a
ToxValDB_ToxRefDB	LEL	=180	mg/kg bw/day	Rat	oral	chronic; 26 weeks	chronic	LONG_REF=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); TITLE=Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6535; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)\|systemic: pathology microscopic-testes-hypospermia\|systemic: pathology gross-sperm measure-sperm count\|systemic: organ weight-testes-absolute\|systemic: hematology-hematocrit (hct)-hematocrit (hct)\|systemic: organ weight-epididymis-absolute\|systemic: pathology microscopic-epididymis-hypospermia\|systemic: organ weight-testes-relative to body weight\|systemic: pathology microscopic-testes-atrophy\|systemic: in life observation-body weight-body weight gain\|systemic: hematology-reticulocyte-reticulocyte\|systemic: hematology-anemia-anemia - macrocytic\|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|hematology\|nonneoplastic histopathology\|organ weight\|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15712215_15712216_15712217_15712218:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d3a9ffd6ed9507e9642f54df3d81bad
ToxValDB_ToxRefDB	LEL	=120	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); TITLE=Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6538; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight\|systemic: pathology microscopic-prostate-corpora amylacea\|systemic: pathology microscopic-pancreas-adenoma\|systemic: pathology microscopic-pancreas-hyperplasia\|systemic: pathology microscopic-liver-granuloma\|systemic: pathology microscopic-skin-hyperkeratosis\|systemic: pathology microscopic-kidney-pigmentation\|systemic: in life observation-body weight-body weight\|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|systemic: pathology microscopic-pancreas-adenoma/carcinoma combined\|systemic: pathology microscopic-skin-acanthosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|cancer\|hematology\|nonneoplastic histopathology\|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712222_15712223_15712224:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb64e198906073edbca62cf4d29f2427
ToxValDB_ToxRefDB	LOAEL	=1200	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); TITLE=Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6538; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-urinary bladder-hyperplasia\|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712219_15712220_15712221:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6a26bd92c8b83cebe2fd53dd63689cf
ToxValDB_ToxRefDB	LOAEL	=500	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=NTP (1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Chronic portion); TITLE=Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6538; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-pancreas-hyperplasia\|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712222_15712223_15712224:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f86c2a607defe39bdf0749f432787119
ToxValDB_ToxRefDB	NEL	=625	mg/kg bw/day	Rat	oral	chronic; 91 days	chronic	LONG_REF=(1982) CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY). NTP-80-25, NIH Publication No. 82-1769. (Subchronic Rat); TITLE=CARCINOGENESIS BIOASSAY OF BUTYL BENZYL PHTHALATE (CAS NO. 85-68-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDY); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6406; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight\|systemic: pathology microscopic-testes-degeneration\|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711638_15711639_15711640_15711641:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a8ab272d484802836a92ce491cfc5328
ToxValDB_ToxRefDB	NEL	=60	mg/kg bw/day	Rat	oral	chronic; 26 weeks	chronic	LONG_REF=(1997) Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies). NTP TR 458, NIH Publication No. 97-3374. (Subchronic portion); TITLE=Toxicology and Carcinogenesis Studies of Butyl Benzyl Phthalate (CAS No. 85-68-7) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6535; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-epididymis-hypospermia\|systemic: organ weight-epididymis-absolute\|systemic: organ weight-testes-relative to body weight\|systemic: pathology microscopic-testes-atrophy\|systemic: in life observation-body weight-body weight gain\|systemic: hematology-anemia-anemia - macrocytic\|systemic: in life observation-body weight-body weight\|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)\|systemic: hematology-reticulocyte-reticulocyte\|systemic: pathology microscopic-testes-hypospermia\|systemic: organ weight-testes-absolute\|systemic: pathology gross-sperm measure-sperm count\|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)\|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)\|systemic: hematology-hematocrit (hct)-hematocrit (hct); TOXICOLOGICAL_EFFECT_CATEGORY=body weight\|hematology\|nonneoplastic histopathology\|organ weight\|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15712215_15712216_15712217_15712218:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb1efc17c34635a85b2963491c427651

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	YPC4PJX59M	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YPC4PJX59M"}
openFDA substances	FDA UNII substance identifier	YPC4PJX59M	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YPC4PJX59M"}
openFDA substances	FDA UNII substance identifier	YPC4PJX59M	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YPC4PJX59M"}
openFDA substances	FDA UNII substance identifier	YPC4PJX59M	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C19H20O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"YPC4PJX59M"}

Butyl Benzyl Phthalate (BBP) NOAEL Studies