NOAEL Studies
Preservative
Butylparaben NOAEL Studies
INCI: BUTYLPARABEN
CAS: 94-26-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 10 | mg/kg bw/day | rat | oral | 8 week | Subchronic | SCCS; Tox Industrial Health; 17:31-39; 2001; Oishi S. |
| COSMOS DB | LOAEL | 14.3999996185 | mg/kg bw/day | mouse | oral | 10 week | Subchronic | PAFA; ARCH TOXICOL 76:423-429, |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 56 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 14 | mg/kg bw/day | mouse | oral | 70 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 800 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 900 | mg/kg bw/day | mouse | oral | 714 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1875 | mg/kg bw/day | mouse | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4000 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 39.3 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1133; Record_ID=adme_parameters_381; Data_Type=Measured; DTXSID=DTXSID3020209; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=39.3; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE adme parameters | Clint | 271 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1136; Record_ID=adme_parameters_381; Data_Type=Measured; DTXSID=DTXSID3020209; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=271.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE adme parameters | Fu | 0.0356 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=1134; Record_ID=adme_parameters_381; Data_Type=Measured; DTXSID=DTXSID3020209; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0356; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE adme parameters | Fu | 0.04157 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1135; Record_ID=adme_parameters_381; Data_Type=Measured; DTXSID=DTXSID3020209; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.04157; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
NTP ICE endocrine 27 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 4.6867652031015 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5930; RecordID=ERPathway2016_190; DatasetName=ERPathway2016; DTXSID=DTXSID3020209; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=4.6867652031015; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | AC50/EC50/IC50 | 41100 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13264; Record_ID=endocrine_invitro_4105; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=41100; Reported_Response_Unit=nM; Response=41100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2011; 21945941; 10.1016/j.taap.2011.09.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | AC50/EC50/IC50 | 68000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13265; Record_ID=endocrine_invitro_4106; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=68000; Reported_Response_Unit=nM; Response=68000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | AC50/EC50/IC50 | 620000 | nM | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=184; Record_ID=endocrine_invitro_178; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=620000; Reported_Response_Unit=nM; Response=620000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | ACC | 1.98886677293605 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5931; RecordID=ERPathway2016_190; DatasetName=ERPathway2016; DTXSID=DTXSID3020209; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=1.98886677293605; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | IC01 | 17300 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13019; Record_ID=endocrine_invitro_4031; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=17300; Reported_Response_Unit=IC01 (nM); Response=17300; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | IC50 | 7100 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13282; Record_ID=endocrine_invitro_4115; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Antagonist; Endpoint=IC50; Reported_Response=7.0999999999999998E-6; Reported_Response_Unit=IC50 (M); Conversion_Factor=1000000000; Conversion_Factor_Value=1000000000; Converted_Response=7099.99999999999; Converted_Response_Unit=nM; Response=7100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LEL | 10000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14964; Record_ID=endocrine_invitro_4400; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2007; 17481686; 10.1016/j.taap.2007.03.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 100 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1050; Record_ID=endocrine_invivo_413; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=600; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol benzoate; Reference=Hossaini et al. 2000; 10722885; 10.1016/s0278-6915(99)00160-x|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 800 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 70; Age_Ovariectomized_or_Castrated=6 to 8 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1052; Record_ID=endocrine_invivo_419; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=800; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Routledge et al. 1998; 9875295; 10.1006/taap.1998.8544|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 1000 | mg/kg bw/day | Mouse | Subcutaneous | Treatment_Duration=7 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1054; Record_ID=endocrine_invivo_444; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Reported_Strain=C57BL/6J; Strain=C57BL/6; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Ohta et al. 2012; 23037998; 10.2131/jts.37.879|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 50 | mg/kg bw/day | Mouse | Subcutaneous | Treatment_Duration=7 days; Age_at_First_Dose=PND 68; Age_Ovariectomized_or_Castrated=PND 56; Time_Elapsed_Between_Surgery_and_Treatment=12 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1056; Record_ID=endocrine_invivo_437; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=50; Response_Unit=mg/kg/day; Species=Mouse; Reported_Strain=C3H; Strain=C3H; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Goswami and Kalita 2012; Not available; Not available|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 400 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1057; Record_ID=endocrine_invivo_438; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=400; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=400; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Routledge et al. 1998; 9875295; 10.1006/taap.1998.8544|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 600 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1059; Record_ID=endocrine_invivo_439; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=600; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=1200; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Routledge et al. 1998; 9875295; 10.1006/taap.1998.8544|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 70 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1061; Record_ID=endocrine_invivo_440; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=70; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=210; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | LOEL | 200 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1063; Record_ID=endocrine_invivo_441; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Routledge et al. 1998; 9875295; 10.1006/taap.1998.8544|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5926; RecordID=ARPathway2016_1738; DatasetName=ARPathway2016; DTXSID=DTXSID3020209; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Model Score | 0.251 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5932; RecordID=ERPathway2016_190; DatasetName=ERPathway2016; DTXSID=DTXSID3020209; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.251; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | RBA | 0.0029 | unitless | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=2474; Record_ID=endocrine_invitro_178; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Binding; Endpoint=RBA; Reported_Response=2.8999999999999998E-3; Reported_Response_Unit=Unitless; Response=0.0029; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Relative potency | 120 | % | - | - | - | In Vitro; AR Transactivation-Agonist | sheet=Data_invitro; excel_row=11132; Record_ID=endocrine_invitro_4017; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=120; Reported_Response_Unit=%; Response=120; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kolšek et al. 2015; 25192815; 10.1016/j.tiv.2014.08.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 113.6 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 19 to 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=734; Record_ID=endocrine_invivo_413; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=113.6; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=600.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol benzoate; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 126.7 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 56 to 70; Age_Ovariectomized_or_Castrated=6 to 8 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=735; Record_ID=endocrine_invivo_419; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=126.7; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1200.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 120 | % | Mouse | Subcutaneous | Treatment_Duration=7 days; Age_at_First_Dose=PND 68; Age_Ovariectomized_or_Castrated=PND 56; Time_Elapsed_Between_Surgery_and_Treatment=12 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=736; Record_ID=endocrine_invivo_437; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Mouse; Reported_Strain=C3H; Strain=C3H; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Goswami and Kalita 2012; Not available; Not available|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 123.1 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=738; Record_ID=endocrine_invivo_438; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=123.1; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=400.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 117.9 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=739; Record_ID=endocrine_invivo_439; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=117.9; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=1200.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 30 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=741; Record_ID=endocrine_invivo_440; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=30; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=210; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
| NTP ICE endocrine | Uterine weight increase vs control | 114.3 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21 to 22; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=743; Record_ID=endocrine_invivo_441; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020209; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=114.3; Response_Unit=%; Species=Rat; Reported_Strain=Alpk:AP; Strain=Alderley Park; Sex=Female; Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020209; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020209 |
SCCS Opinion 38 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =2 | mg/kg bw/day | mouse | oral | - | repeated dose toxicity | p.35 |
| SCCS Opinion | NOAEL | =2 | % | rat | oral | 12 weeks | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =5 | - | - | - | developmental | reproductive toxicity | p.38 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | - | - | - | NOAEL study | p.99 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw | mouse | - | 7 days | NOAEL study | p.103 |
| SCCS Opinion | NOAEL | =10.4 | mg/kg bw/day | rat | oral | 21 days | reproductive toxicity | p.41 |
| SCCS Opinion | NOAEL | =14.4 | mg/kg/day | rat | oral | 8 weeks | developmental toxicity | p.4 |
| SCCS Opinion | NOAEL | =14.4 | mg/kgbw/day | rat | oral | 21 days | reproductive toxicity | p.41 |
| SCCS Opinion | NOAEL | =26.9 | mg/kg | mouse | - | 7 days | NOAEL study | p.103 |
| SCCS Opinion | NOAEL | =40 | % | rat | oral | 8week | repeated dose toxicity | p.94 |
| SCCS Opinion | NOAEL | =50 | mg/kg | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| SCCS Opinion | NOAEL | =67.8 | mg/kg bw/day | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| SCCS Opinion | NOAEL | =93 | - | rat | - | - | NOAEL study | p.93 |
| SCCS Opinion | NOAEL | =100 | mg/kg/day | rat | oral | 14 days | developmental toxicity | p.4 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | - | - | NOAEL study | p.91 |
| SCCS Opinion | NOAEL | =150 | mg/kg bw/day | rat | - | 57 days | NOAEL study | p.103 |
| SCCS Opinion | NOAEL | =160 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.97 |
| SCCS Opinion | NOAEL | =200 | mg/ kg bw/day | rat | - | - | reproductive toxicity | p.96 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | 3 days | repeated dose toxicity | p.94 |
| SCCS Opinion | NOAEL | =310 | mg/kg | mouse | - | - | NOAEL study | p.103 |
| SCCS Opinion | NOAEL | =325 | mg/kg bw/day | rat | - | - | NOAEL study | p.37 |
| SCCS Opinion | NOAEL | =325 | mg/kg/day | - | - | developmental | reproductive toxicity | p.45 |
| SCCS Opinion | NOAEL | =325 | mg/kgbw/d | human | - | developmental | repeated dose toxicity | p.64 |
| SCCS Opinion | NOAEL | =325 | mg/kg bw/d | human | - | - | repeated dose toxicity | p.32 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | rat | oral | 10 weeks | NOAEL study | p.91 |
| SCCS Opinion | NOAEL | =900 | mg/kg bw/day | mouse | oral | 30 days | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =940 | mg/kg bw/day | rat | - | 78 weeks | NOAEL study | p.37 |
| SCCS Opinion | NOAEL | =949 | mg/kg/day | mouse | - | - | NOAEL study | p.93 |
| SCCS Opinion | NOAEL | =950 | mg/kg bw/day | - | - | - | NOAEL study | p.93 |
| SCCS Opinion | NOAEL | =1000 | mg/kg/day | - | - | - | NOAEL study | p.9 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.39 |
| SCCS Opinion | NOAEL | =1000 | mg/kg/day | rat | - | 15-day | reproductive toxicity | p.42 |
| SCCS Opinion | NOAEL | =1086.6 | mg/kg bw/day | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| SCCS Opinion | NOAEL | =1504 | mg/kg/day | mouse | oral | 10 weeks | NOAEL study | p.4 |
| SCCS Opinion | NOAEL | =1504 | mg/kg bw/day | mouse | oral | 27 days | reproductive toxicity | p.40 |
| SCCS Opinion | NOAEL | =5000 | ppm | rat | oral | 11 weeks | reproductive toxicity | p.38 |
| SCCS Opinion | NOAEL | =10000 | ppm | rat | oral | - | reproductive toxicity | p.7 |
| SCCS Opinion | NOAEL | =40000 | ppm | rat | oral | 11 weeks | reproductive toxicity | p.39 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15598002:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b048c6dbe69a4b01fe709db9337469a |
ToxValDB Uterotrophic Hershberger DB 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =7 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713390_15713543_15713584:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3259703114ec78b3e7ccdac11a59c9d2 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =21 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713390_15713543_15713584:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a6c312d21b43e088c48077647a29cd78 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =50 | mg/kg bw/day | Mouse | injection | short-term; 7 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713573_15713689:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5aeefcb7cfc272fa4c750e7c369c197b |
| ToxValDB Uterotrophic Hershberger DB | LEL | =70 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713390_15713543_15713584:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bf3510d8489240a179c0024d68b2da7 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =100 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2e10c74dfb7a3b147a835b84391addd |
| ToxValDB Uterotrophic Hershberger DB | LEL | =200 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a05d84a0ed9320773b120af2fa1069df |
| ToxValDB Uterotrophic Hershberger DB | LEL | =210 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28bce86c345d06df5f90e2c63c4b6acc |
| ToxValDB Uterotrophic Hershberger DB | LEL | =400 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e18ea244242cdf96c554b97898b038cc |
| ToxValDB Uterotrophic Hershberger DB | LEL | =600 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_15546b6afd878ec1979bbaff7eb491e1 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =800 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b704ef20f7aaa9ece645e945e9d82d02 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =1000 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0 |::| 1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713590_15713632_15713651_15713665_15713672_15713678_15713682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04f2eeb4628c57559906ca40f5b18cad |
Regulatory source 65 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 2 | % | rat | oral | 12 weeks | - | p.36 |
| Regulatory source | - | =2 | mg/kg bw/day | rat | - | - | - | p.96 |
| Regulatory source | - | =2 | mg/kg bw/day | rat | - | 17 days | - | p.41 |
| Regulatory source | - | 2 | mg/ kg bw /day | rat | - | - | - | p.96 |
| Regulatory source | - | =10 | mg/kg bw/day | - | - | - | - | p.99 |
| Regulatory source | - | =10 | mg/kg bw | mouse | - | 7 days | - | p.103 |
| Regulatory source | - | 26.9 | mg/kg | mouse | - | 7 days | - | p.103 |
| Regulatory source | - | 26.9 | mg/kg | mouse | - | - | - | p.103 |
| Regulatory source | - | 93 | - | rat | - | - | - | p.93 |
| Regulatory source | - | =100 | mg/kg bw/day | rat | - | - | - | p.91 |
| Regulatory source | - | 100 | mg/kg bw/ day | rat | - | 3 days | - | p.91 |
| Regulatory source | - | =150 | mg/kg bw/day | rat | - | 57 days | - | p.103 |
| Regulatory source | - | 310 | mg/kg | mouse | - | - | - | p.103 |
| Regulatory source | - | 325 | mg/kg bw/day | rat | - | - | - | p.37 |
| Regulatory source | - | 400 | mg/kg bw/day | rat | oral | 10 weeks | - | p.91 |
| Regulatory source | - | 400 | mg/kg bw/day | rat | - | 3 days | - | p.91 |
| Regulatory source | - | 900 | mg/kg bw/day | mouse | oral | 30 days | - | p.36 |
| Regulatory source | - | 900 | mg/kg bw/day | mouse | oral | 12 weeks | - | p.37 |
| Regulatory source | - | 940 | mg/kg bw/day | rat | - | 78 weeks | - | p.37 |
| Regulatory source | - | 949 | mg/kg/day | mouse | - | - | - | p.93 |
| Regulatory source | - | 949 | mg/kg bw/day | mouse | - | - | - | p.39 |
| Regulatory source | - | 950 | mg/kg bw/day | - | - | - | - | p.93 |
| Regulatory source | - | 950 | mg/kg bw/day | mouse | - | - | - | p.93 |
| Regulatory source | - | 1000 | mg/kg/day | - | - | - | - | p.9 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | - | 3 days | - | p.94 |
| Regulatory source | - | 1504 | mg/kg/day | mouse | oral | 10 weeks | - | p.4 |
| Regulatory source | - | 1504 | mg/kg bw/day | - | - | - | - | p.41 |
| Regulatory source | - | 5000 | ppm | - | - | - | - | p.44 |
| Regulatory source | - | 10000 | ppm | rat | oral | - | - | p.40 |
| Regulatory source | developmental toxicity | =14.4 | mg/kg/day | rat | oral | 8 weeks | developmental toxicity | p.4 |
| Regulatory source | developmental toxicity | =100 | mg/kg/day | rat | oral | 14 days | developmental toxicity | p.4 |
| Regulatory source | developmental toxicity | =160 | mg/kg bw/day | rat | - | developmental | developmental toxicity | p.97 |
| Regulatory source | developmental toxicity | 1000 | mg/kg/day | rat | oral | 14 days | developmental toxicity | p.4 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | rat | oral | Developmental | developmental toxicity | p.39 |
| Regulatory source | repeated dose toxicity | 2 | mg/kg bw/day | mouse | oral | - | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | 2 | mg/kg bw/day | - | oral | subchronic | repeated dose toxicity | p.35 |
| Regulatory source | repeated dose toxicity | ~40 | % | rat | oral | 8week | repeated dose toxicity | p.94 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| Regulatory source | repeated dose toxicity | 67.8 | mg/kg bw/day | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| Regulatory source | repeated dose toxicity | =250 | mg/kg bw/day | rat | oral | 3 days | repeated dose toxicity | p.94 |
| Regulatory source | repeated dose toxicity | 325 | mg/kgbw/d | human | - | developmental | repeated dose toxicity | p.64 |
| Regulatory source | repeated dose toxicity | 325 | mg/kg bw/d | human | - | developmental | repeated dose toxicity | p.64 |
| Regulatory source | repeated dose toxicity | =1086.6 | mg/kg bw/day | rat | oral | 8 weeks | repeated dose toxicity | p.101 |
| Regulatory source | reproductive toxicity | =2 | mg/kg bw/day | rat | - | 17 days | reproductive toxicity | p.41 |
| Regulatory source | reproductive toxicity | 2 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 2 | mg/kg bw/day | mouse | oral | - | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 2 | mg/kg bw/day | mouse | oral | developmental | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 5 | - | - | - | developmental | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 10.4 | mg/kg bw/day | rat | oral | 21 days | reproductive toxicity | p.41 |
| Regulatory source | reproductive toxicity | =14.4 | mg/kgbw/day | rat | oral | 21 days | reproductive toxicity | p.41 |
| Regulatory source | reproductive toxicity | =100 | mg/kg bw/day | rat | - | - | reproductive toxicity | p.96 |
| Regulatory source | reproductive toxicity | =160 | mg/kg bw/day | rat | oral | - | reproductive toxicity | p.98 |
| Regulatory source | reproductive toxicity | 200 | mg/ kg bw/day | rat | - | - | reproductive toxicity | p.96 |
| Regulatory source | reproductive toxicity | 325 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 325 | mg/kg/day | - | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 325 | mg/kg bw/d | - | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 900 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | rat | oral | Developmental | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | - | 15-day | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | - | - | developmental | reproductive toxicity | p.43 |
| Regulatory source | reproductive toxicity | 1504 | mg/kg bw/day | mouse | oral | 27 days | reproductive toxicity | p.40 |
| Regulatory source | reproductive toxicity | =5000 | ppm | rat | oral | 11 weeks | reproductive toxicity | p.38 |
| Regulatory source | reproductive toxicity | 10000 | ppm | rat | oral | - | reproductive toxicity | p.7 |
| Regulatory source | reproductive toxicity | 10000 | ppm | - | - | 3 week | reproductive toxicity | p.8 |
| Regulatory source | reproductive toxicity | 40000 | ppm | rat | oral | 11 weeks | reproductive toxicity | p.39 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3QPI1U3FV8 | UNII | - | - | - | chemical | - |