NOAEL Studies
Cosmetic Ingredient
Butyraldehyde NOAEL Studies
INCI: BUTYRALDEHYDE
CAS: 123-72-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 23 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=6da144b9-06af-4954-847b-d4c6b748affe_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=6da144b9-06af-4954-847b-d4c6b748affe/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=9c15c035-4377-418a-84f0-1f8166f66ed4 |
| ECHA | LOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=6da144b9-06af-4954-847b-d4c6b748affe_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=6da144b9-06af-4954-847b-d4c6b748affe/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=9c15c035-4377-418a-84f0-1f8166f66ed4 |
| ECHA | LOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=6da144b9-06af-4954-847b-d4c6b748affe_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=6da144b9-06af-4954-847b-d4c6b748affe/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=9c15c035-4377-418a-84f0-1f8166f66ed4 |
| ECHA | NOAEL | 625 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=62ae4546-704b-4995-8716-de7585c01eac_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=62ae4546-704b-4995-8716-de7585c01eac/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=f0420bb9-c5c6-4c2a-8c01-b862d6db741b |
| ECHA | NOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=d685f446-1b83-41bd-9c5f-f0e42b17b163_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=d685f446-1b83-41bd-9c5f-f0e42b17b163/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=e76541c6-5787-4993-89b5-956d1f2031c0 |
| ECHA | NOAEL | 625 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=62ae4546-704b-4995-8716-de7585c01eac_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=62ae4546-704b-4995-8716-de7585c01eac/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=f0420bb9-c5c6-4c2a-8c01-b862d6db741b |
| ECHA | NOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=d685f446-1b83-41bd-9c5f-f0e42b17b163_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=d685f446-1b83-41bd-9c5f-f0e42b17b163/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=e76541c6-5787-4993-89b5-956d1f2031c0 |
| ECHA | NOAEL | 625 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=62ae4546-704b-4995-8716-de7585c01eac_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=62ae4546-704b-4995-8716-de7585c01eac/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=f0420bb9-c5c6-4c2a-8c01-b862d6db741b |
| ECHA | NOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=d685f446-1b83-41bd-9c5f-f0e42b17b163_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=d685f446-1b83-41bd-9c5f-f0e42b17b163/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=e76541c6-5787-4993-89b5-956d1f2031c0 |
| ECHA | NOEL | 625 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=7263e9a6-e186-47c3-ae1b-a42a41ca5175_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=7263e9a6-e186-47c3-ae1b-a42a41ca5175/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=3a3d549a-6e0b-4c4b-b094-b8c852749df9 |
| ECHA | NOEL | 625 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=7263e9a6-e186-47c3-ae1b-a42a41ca5175_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=7263e9a6-e186-47c3-ae1b-a42a41ca5175/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=3a3d549a-6e0b-4c4b-b094-b8c852749df9 |
| ECHA | NOEL | 625 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6z; document=7263e9a6-e186-47c3-ae1b-a42a41ca5175_693af9ee-6f06-4671-9d7e-6a8c9438d44d.i6d; document_key=7263e9a6-e186-47c3-ae1b-a42a41ca5175/693af9ee-6f06-4671-9d7e-6a8c9438d44d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=3a3d549a-6e0b-4c4b-b094-b8c852749df9 |
| ECHA | LEL | ~16600 | mg/m3 | Rat | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/3/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15796680:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d313c12bbde1c828cb5e652614e55ed5 |
| ECHA | LEL | ~4570 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/3/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15798295_15798296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ddd6da6b005c540b7f8236085a6c4863 |
| ECHA | LEL | ~3030 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/3/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15798295_15798296:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd66fc517ba97ed0567e4455a76ab0ad |
| ECHA | LOAEC | =368.647 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827157:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0768e911d571627805193d0307d697ca |
| ECHA | LOAEC | =5898.35 | mg/m3 | Dog | inhalation | short-term; 2 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827507:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4bd4882c15ef609d332d5e3a8b8ae06 |
| ECHA | LOAEL | =75 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2891; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/2?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15850600:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_21bb109f1eaf9c2d16260924ca6f4744 |
| ECHA | NOAEC | =151.293 | mg/m3 | Rat | inhalation | subchronic; 12 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827335:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4c3c58d313283f8b9524c15c6406d444 |
| ECHA | NOAEC | =5898.35 | mg/m3 | Mouse | inhalation | short-term; 2 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/3?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15829188:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b25b573c553b737b32a9a1c84f7f43af |
| ECHA | NOAEL | =625 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d22141b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/2?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15850599:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f2d78ef0155fb4fa583fc4bf2ead0ee4 |
| ECHA | NOAEL | =150 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2893; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/2?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15850601:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9ae0262d40b43627a3f5d39d25929738 |
| ECHA | NOEL | =625 | mg/kg bw/day | Rat | oral | short-term; 12 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4ee4b0a7c65d22141f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15033/7/6/2?documentUUID=693af9ee-6f06-4671-9d7e-6a8c9438d44d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15837202:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f9fb96c3e3c40ef8d4e19f378ffe461 |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2026 | IARC Monographs | {"additional_info":null,"evaluation_year":2026,"source_table":"iarc_classifications","volume":"141"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2026 | IARC Monographs | {"additional_info":null,"evaluation_year":2026,"source_table":"iarc_classifications","volume":"141"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2026 | IARC Monographs | {"additional_info":null,"evaluation_year":2026,"source_table":"iarc_classifications","volume":"141"} |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2490 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2078; row=13308; data_type=In Vivo; mixture=Chemical; chemical_name=Butyraldehyde; preferred_name=Butyraldehyde; dtxsid=DTXSID8021513; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021513; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5890 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2080; row=13309; data_type=In Vivo; mixture=Chemical; chemical_name=Butyraldehyde; preferred_name=Butyraldehyde; dtxsid=DTXSID8021513; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8021513; source_file=acute_oral.xlsx |
NTP ICE eye irritation 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2307; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2307; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2307; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2307; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2305; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2305; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2305; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2305; Record_ID=eye_irritation_223; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Intensity | 0.15 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2309; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Intensity; Response=0.15; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Intensity | 0.15 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2309; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Intensity; Response=0.15; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Intensity | 0.15 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2309; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Intensity; Response=0.15; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Intensity | 0.15 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2309; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Intensity; Response=0.15; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Lag time | 80 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2310; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Lag time; Response=80; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Lag time | 80 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2310; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Lag time; Response=80; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Lag time | 80 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2310; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Lag time; Response=80; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Lag time | 80 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2310; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Lag time; Response=80; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Plateau level | 18 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2306; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Plateau level; Response=18; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Plateau level | 18 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2306; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Plateau level; Response=18; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Plateau level | 18 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2306; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Plateau level; Response=18; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE eye irritation | Plateau level | 18 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2306; Record_ID=eye_irritation_1329; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Vitrigel; Endpoint=Plateau level; Response=18; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4579; Record_ID=skin_sensitization_invivo_1101; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80016-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE skin sensitization | Induction dose per skin area | 675 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4578; Record_ID=skin_sensitization_invivo_1101; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=675; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80016-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4584; Record_ID=skin_sensitization_invivo_1101; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021513; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80016-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021513; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021513 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =56034.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15513136:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7276ea3bc6b727026f771d6c7a9bef5f |
ToxValDB TX TCEQ 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =345.054 | mg/m3 | Rat | inhalation | chronic; 14 weeks | chronic | LONG_REF=United States Environmental Protection Agency (USEPA). 1988. Butyraldehyde Vapor Inhalation by Dogs and Rats for 14 and 23 Weeks Respectively and a 12 Week Vapor Inhalation Study in Rats with Attached Appendices and Cover Letter dated 02/22/88. USEPA Office of Toxic Substances FYI-OTS-1088-0647D (NTIS/OTS-0000647):102; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butyraldehyde.pdf; YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; ORIGINAL_YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; TOXICOLOGICAL_EFFECT=Hyperplasia, inflammation, and squamous metaplasia of the nasal tissues (nasal irritation) in SD rats and male beagle dogs; STUDY_GROUP=TX TCEQ:15954572:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e4b034dd2bc3cc9a2bfa87f7464c1835 |
| ToxValDB TX TCEQ | NOAEL | =51.3 | ppm | Rat | - | subchronic; 12 weeks | subchronic | LONG_REF=United States Environmental Protection Agency (USEPA). 1988. Butyraldehyde Vapor Inhalation by Dogs and Rats for 14 and 23 Weeks Respectively and a 12 Week Vapor Inhalation Study in Rats with Attached Appendices and Cover Letter dated 02/22/88. USEPA Office of Toxic Substances FYI-OTS-1088-0647D (NTIS/OTS-0000647):102; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butyraldehyde.pdf; YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; ORIGINAL_YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; STUDY_GROUP=TX TCEQ:15954574:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c928a523c052280fdbaef73c82ecf865 |
| ToxValDB TX TCEQ | NOAEL | =678.311 | mg/m3 | Human | inhalation | acute; 30 minutes | clinical | LONG_REF=Sim VM, RE Pattle. 1957. Effect of possible smog irritants on human subjects. J Am Med Asso. 163(13): 1908-1913; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butyraldehyde.pdf; YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; ORIGINAL_YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; TOXICOLOGICAL_EFFECT=Absence of sensory irritation in human volunteers; STUDY_GROUP=TX TCEQ:15954575:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_14073f75b01b530123f425990635c8eb |
| ToxValDB TX TCEQ | NOAEL (HEC ADJ) | =27.0145 | mg/m3 | Rat | inhalation | subchronic; 12 weeks | subchronic | LONG_REF=United States Environmental Protection Agency (USEPA). 1988. Butyraldehyde Vapor Inhalation by Dogs and Rats for 14 and 23 Weeks Respectively and a 12 Week Vapor Inhalation Study in Rats with Attached Appendices and Cover Letter dated 02/22/88. USEPA Office of Toxic Substances FYI-OTS-1088-0647D (NTIS/OTS-0000647):102; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/butyraldehyde.pdf; YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; ORIGINAL_YEAR=March 14, 2014' Revised Odor Value: September 14, 2015; STUDY_GROUP=TX TCEQ:15954576:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a52cc6369a90ca378ae75a3245ca661 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | H21352682A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H21352682A"} |
| openFDA substances | FDA UNII substance identifier | H21352682A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H21352682A"} |
| openFDA substances | FDA UNII substance identifier | H21352682A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H21352682A"} |
| openFDA substances | FDA UNII substance identifier | H21352682A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H21352682A"} |