Good Cosmetic Ingredient NOAEL Data

C12-13 Pareth-9

INCI: C12-13 PARETH-9

CAS Number
66455-14-9
Function
Surfactant – emulsifying agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Acceptable — within CIR group MoS range (113 to >2,600)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for C12-13 Pareth-9. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 500 mg/kg bw/day oral rat oral REACH

Expert Verdict

PEG-containing surfactant with potential 1,4-dioxane contamination risk; CIR noted renal toxicity concern when applied to damaged or burned skin.

⚠️
Concern Level: Moderate

Regulatory Flags

epa_safer_alternative ifra_fragrance

Frequently Asked Questions

Is C12-13 Pareth-9 safe in cosmetics?

PEG-containing surfactant with potential 1,4-dioxane contamination risk; CIR noted renal toxicity concern when applied to damaged or burned skin. The EU classifies C12-13 Pareth-9 as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is C12-13 Pareth-9 allowed in the EU?

C12-13 Pareth-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does C12-13 Pareth-9 do in cosmetics?

C12-13 Pareth-9 functions as: Surfactant – emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 66455-14-9.

What is the Margin of Safety for C12-13 Pareth-9?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for C12-13 Pareth-9?

The NOAEL (No Observed Adverse Effect Level) for C12-13 Pareth-9 is 500 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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