Moderate Cosmetic Ingredient

C16-22 Acid Amide MEA

INCI: C16-22 ACID AMIDE MEA

CAS Number
Not assigned as a single CAS (UVCB — amides of C16-22 fatty acids with monoethanolamine)
Function
Cleansing; surfactant
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Conditional — adequate only when nitrosamine-free

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Nitrosamine contamination risk: MEA-based amides can form nitrosamines in the presence of nitrosating agents. CPSR must include nitrosamine testing or a declaration of absence. Do not co-formulate with nitrosating preservatives such as sodium nitrite.

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Concern Level: High

Frequently Asked Questions

Is C16-22 Acid Amide MEA safe in cosmetics?

Nitrosamine contamination risk: MEA-based amides can form nitrosamines in the presence of nitrosating agents. CPSR must include nitrosamine testing or a declaration of absence. Do not co-formulate with nitrosating preservatives such as sodium nitrite. The EU classifies C16-22 Acid Amide MEA as "prohibited". Safety rating: MODERATE.

Is C16-22 Acid Amide MEA allowed in the EU?

C16-22 Acid Amide MEA EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does C16-22 Acid Amide MEA do in cosmetics?

C16-22 Acid Amide MEA functions as: Cleansing; surfactant. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned as a single CAS (UVCB — amides of C16-22 fatty acids with monoethanolamine).

What is the Margin of Safety for C16-22 Acid Amide MEA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check C16-22 Acid Amide MEA compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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