NOAEL Studies
Active Ingredient
Caffeine NOAEL Studies
INCI: CAFFEINE
CAS: 58-08-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 54 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 21 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; NTP TR |
| COSMOS DB | LOAEL | 23 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | REACH; NTP report |
| COSMOS DB | LOAEL | 29 | mg/kg bw/day | rat | oral | 21 day | Developmental | PAFA; FOOD CHEM TOXICOL 25:647-662 |
| COSMOS DB | LOAEL | 100 | mg/kg bw/day | rat | oral | 6-20 Gestation day | Developmental | PAFA; FOOD CHEM TOXICOL 25:125-13 |
| COSMOS DB | NOAEL | 3 | mg/kg bw/day | rat | oral | 1 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 6 | mg/kg bw/day | rat | oral | 19 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 130 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 12.5 | mg/kg bw/day | monkey | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 13 | mg/kg bw/day | monkey | oral | 287 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 15 | mg/kg bw/day | rat | oral | 5 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rat | oral | 105 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 22.5 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 24.7 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 26.4 | mg/kg bw/day | mouse | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 28 | mg/kg bw/day | monkey | oral | 287 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 29 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 30 | mg/kg bw/day | rat | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 32.5 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 35 | mg/kg bw/day | rat | oral | 180 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 36 | mg/kg bw/day | rat | oral | 21 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 37 | mg/kg bw/day | swine | oral | 56 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 40 | mg/kg bw/day | rat | oral | 77 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 49 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 49.3 | mg/kg bw/day | rat | oral | 819 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | rat | oral | 36 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 55 | mg/kg bw/day | mouse | oral | 560 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 60 | mg/kg bw/day | rat | oral | 3 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 65 | mg/kg bw/day | syrian hamster | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 68 | mg/kg bw/day | rat | oral | 707 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 75 | mg/kg bw/day | rat | oral | 56 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 75.1 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 80 | mg/kg bw/day | rat | oral | 22 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 83 | mg/kg bw/day | rat | oral | 21 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 86.6 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 92 | mg/kg bw/day | mouse | oral | 105 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | cat | oral | 21 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 115 | mg/kg bw/day | rat | oral | 38 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 116 | mg/kg bw/day | rat | oral | 14 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 122 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 125 | mg/kg bw/day | mouse | oral | 69 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 135 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 136 | mg/kg bw/day | rat | oral | 100 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | mouse | oral | 11 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 159 | mg/kg bw/day | mouse | oral | 14 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 177 | mg/kg bw/day | rat | oral | 105 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 179 | mg/kg bw/day | rat | oral | 84 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 220 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 525 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 279 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 375 | mg/kg bw/day | mouse | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 800 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | ca.50.7 | mg/kg bw/day | rat | oral: drinking water | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=05d6062d-1f89-4469-afc1-a43a1330ef13 |
| ECHA | NOAEL | ca.10.1 | mg/kg bw/day | rat | oral: drinking water | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=2ede575f-8548-4f4b-abbd-5f2ec4ce9cf4 |
| ECHA | NOAEL | >204.5 | mg/kg bw/day | rat | oral: drinking water | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=ca841f13-5b7a-42ad-94c7-eaf6bd1e9209 |
| ECHA | NOAEL | 22 | mg/kg bw/day | mouse | oral: drinking water | - | fertility, other | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=1203550c-a261-4010-a59c-0b8c97c1efd3 |
| ECHA | NOAEL | 88 | mg/kg bw/day | mouse | oral: drinking water | - | fertility, other | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=3d4404f7-0dd6-4089-913d-8421fb642a5a |
| ECHA | NOAEL | >=167.4 | mg/kg bw/day | mouse | oral: drinking water | - | sub-chronic toxicity: oral | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=42da67e7-0c96-4c74-b1c9-6a7d7d9dde97 |
| ECHA | NOAEL | >=179.4 | mg/kg bw/day | mouse | oral: drinking water | - | sub-chronic toxicity: oral | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=9f4de77d-d0f0-4d3a-a8f5-4d141e5e7b3e |
| ECHA | NOAEL | >=245 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=0ed18a86-afcf-40e6-b22c-5cc9724aa93d |
| ECHA | NOAEL | >=285 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=fe0354cf-8ddf-45dc-b0ff-3d8cad7f1f1a |
| ECHA | NOAEL | <=10 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; upper_value=10; entry_uuid=24431966-05c5-4a97-ac0e-f10c8fedd194 |
| ECHA | NOAEL | >40 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=01ad21de-5777-4336-aa4c-165d9bb87fd1 |
| ECHA | NOAEL | <=12.5 | mg/kg bw/day | rat | oral: gavage | - | two-generation reproductive toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=2214af21-94a1-4099-8841-0d50ce8b3f8e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=2214af21-94a1-4099-8841-0d50ce8b3f8e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=false; upper_value=12.5; entry_uuid=3a489ecf-3c7d-46d1-b329-d6b93917ae99 |
| ECHA | NOAEL | >80 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=fdac7564-b7c5-428a-a124-ea30d7c1dc10_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=fdac7564-b7c5-428a-a124-ea30d7c1dc10/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=0ab1094b-0577-48c6-b86c-8a5ba732f50c |
| ECHA | LEL | =220 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15801532:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d09c16a00ddf870a912b288aa6c8c9c5 |
| ECHA | LEL | =240 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15801533:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60f121478e18f25d995cb0ab62066ab1 |
| ECHA | LEL | ~35 | mg/kg bw/day | Mouse | oral | - | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15807229:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c9f2de0ab6430569ad836ca9293e11f |
| ECHA | NOAEL | >204.5 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be197; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/3?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823389:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a983fb305b4122db6b6a66d854f7b16 |
| ECHA | NOAEL | >40 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be19b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/3?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824954:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73b80892fb4447abc7adb63c7f09c20f |
| ECHA | NOAEL | >=179.4 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c951f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849582:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a5afd8f60604b96e0efcc41d0c44ba0e |
| ECHA | NOAEL | >=167.4 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c951f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849583:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c06f288f0b41eb82a001dbb33a3d5e0 |
| ECHA | NOAEL | =228 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9531; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849584:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5a953a867ae46f4b8a60d929214c93d8 |
| ECHA | NOAEL | >=245 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e32; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849585:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17765dee3fb76b2ee9f39716c643e2ac |
| ECHA | NOAEL | >=285 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e32; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849586:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_004b05b7ad415b3b6a530a74c7c6fed8 |
| ECHA | NOAEL | =22 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860467_15862166:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c6a6bee87535f587994968145a5344b |
| ECHA | NOAEL | <12.5 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15861087:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36b6ec3a3c42091ac3d6461a940771cb |
| ECHA | NOAEL | =88 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15862048:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee49865606612b67d43b7caedec625b9 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | - |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =192 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7953; row=241; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =367 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_7955; row=242; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.2855 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=29; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.2855; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
| NTP ICE adme parameters | Clint | 1.458 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=31; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.458; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wood 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
| NTP ICE adme parameters | Fu | 0.7335 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=28; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.7335; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
| NTP ICE adme parameters | Fu | 1 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=30; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=44; Record_ID=cancer_2440; Data_Type=WOE; Formulation_Name=Caffeine; Mixture=Chemical; DTXSID=DTXSID0020232; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/69; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
| NTP ICE cancer | Top dose | 1179 | mg/kg bw/day | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=47; Record_ID=cancer_5553; Data_Type=In Vivo; Formulation_ID=Cancer_PID_99; Formulation_Name=Aspirin; Phenacetin; Caffeine; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID0020232; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1179; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-067; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr067/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
| NTP ICE cancer | Top dose | 1.4 | % | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=49; Record_ID=cancer_5556; Data_Type=In Vivo; Formulation_ID=Cancer_PID_99; Formulation_Name=Aspirin; Phenacetin; Caffeine; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID0020232; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1.4; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-067; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr067/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=6186; RecordID=ARPathway2016_1352; DatasetName=ARPathway2016; DTXSID=DTXSID0020232; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232 |
ToxValDB ECOTOX 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =300 | mg/L | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Length; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594869_15597966:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8485b48f0bcab6b65ddb8094551b4abd |
| ToxValDB ECOTOX | LOEL | =30 | mg/L | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Morphology: General morphological changes; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594869_15597966:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4cb913606426a4c787029f9a887818d1 |
| ToxValDB ECOTOX | LOEL | =20 | mg/kg bw/day | Rat | oral | short-term; 22 days | short-term | LONG_REF=- | Biol. Trace Elem. Res.50(3): 229-236 Rossowska,M.J., P. Ghanaei, and T. Nakamoto Effect of Dietary Caffeine and Zinc on the Activity of Antioxidant Enzymes, Zinc, and Copper Concentration of the Heart and Liver in Fast-Growing Rats 1995; TITLE=Effect of Dietary Caffeine and Zinc on the Activity of Antioxidant Enzymes, Zinc, and Copper Concentration of the Heart and Liver in Fast-Growing Rats; AUTHOR=Rossowska,M.J., P. Ghanaei, and T. Nakamoto; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85619; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Enzyme(s): Copper zinc superoxide dismutase (Cu,ZnSOD) activity, heart | Enzyme(s): Manganese superoxide dismutase (MnSOD) activity, heart|Enzyme(s): Superoxide dismutase (SOD) activity, heart | Enzyme(s): Copper zinc superoxide dismutase (Cu,ZnSOD) activity, liver; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15613011:F:-juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=ebbe21765aed7b1b421a03284b700abe |
| ToxValDB ECOTOX | NOEL | =0.5 | mmol/kg | Mouse | injection | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.66:33-43 King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems 1979; TITLE=Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems; AUTHOR=King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild; DOI=10.1016/0165-1218(79)90005-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=181059; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15606066:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=78b10b3044e0ba9b4ac3dc8149a57d71 |
| ToxValDB ECOTOX | NOEL | =2.88 | mg/kg bw/day | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=- | Arch. Toxicol.Suppl.4:443-445 Selmeci-Antal,M., M. Barta-Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol 1980; TITLE=Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol; AUTHOR=Selmeci-Antal,M., M. Barta-Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75289; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613100:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8a15e2f591566bbd7914cc2295e8cc9f |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =44.37 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630507:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26c5764a386fdf4f7523cd5e18794809 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3G6A5W338E | UNII | - | - | - | chemical | - |