Calcium/Magnesium Hydroxyapatite

INCI: CALCIUM/MAGNESIUM HYDROXYAPATITE

CAS Number
Not individually assigned (base Hydroxyapatite: 1306-06-5)
Function
Abrasive; Bulking agent; Oral care agent; Skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. 10%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Adequate (non-nano). Nano form: SCCS evaluated; MoS adequate for oral care within stated limits

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Nano form presents inhalation risk and is prohibited in spray/aerosol products under Regulation 2024/858 (effective Feb 2025). Non-nano form is permitted with adequate margin of safety for oral care; toxicity data based on read-across from base hydroxyapatite.

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Concern Level: Moderate

Frequently Asked Questions

Is Calcium/Magnesium Hydroxyapatite safe in cosmetics?

Nano form presents inhalation risk and is prohibited in spray/aerosol products under Regulation 2024/858 (effective Feb 2025). Non-nano form is permitted with adequate margin of safety for oral care; toxicity data based on read-across from base hydroxyapatite. The EU classifies Calcium/Magnesium Hydroxyapatite as "restricted". Safety rating: GOOD.

Is Calcium/Magnesium Hydroxyapatite allowed in the EU?

Calcium/Magnesium Hydroxyapatite EU regulatory status: restricted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium/Magnesium Hydroxyapatite do in cosmetics?

Calcium/Magnesium Hydroxyapatite functions as: Abrasive; Bulking agent; Oral care agent; Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not individually assigned (base Hydroxyapatite: 1306-06-5).

What is the Margin of Safety for Calcium/Magnesium Hydroxyapatite?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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