NOAEL Studies Cosmetic Ingredient

CAMELLIA SINENSIS EXTRACT NOAEL Studies

CAS: 84650-60-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1 % human - - NOAEL study 106; 101; (0, p.16
CIR Safety Assessment NOAEL =100 mg/kg/d - oral - oral toxicity 200; 2; 100, p.10
CIR Safety Assessment NOAEL =200 mg/kg body weight - oral - oral toxicity 3,600; 200; 2, p.10
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 20000 mg/kg bw/day rat oral 9 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE skin sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 51.9 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1854; Record_ID=skin_sensitization_invitro_475; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=51.9; Reported_Response_Unit=ug/mL; Response=51.9; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP ICE skin sensitization CV75 254 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1856; Record_ID=skin_sensitization_invitro_475; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=h-CLAT; Endpoint=CV75; Reported_Response=254; Reported_Response_Unit=ug/mL; Response=254; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP ICE skin sensitization EC1.5 >200 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6691; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=uM; Response=200; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP ICE skin sensitization EC3 >400 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6692; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=400; Reported_Response_Unit=uM; Response=400; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP ICE skin sensitization Imax 2.13 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6694; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.13; Reported_Response_Unit=Unitless; Response=2.13; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 1 % human - - - p.16
Regulatory source oral toxicity 100 mg/kg/d - oral - oral toxicity p.10
Regulatory source oral toxicity 200 mg/kg body weight - oral - oral toxicity p.10