NOAEL Studies
Cosmetic Ingredient
CAPSICUM ANNUUM EXTRACT NOAEL Studies
CAS: 84625-29-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =2052 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15820056:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_58cf1b4ee1e8066be536ac2dcd15574f |
| ToxValDB_ECHA_IUCLID | NOAEL | =2324 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c805e4b0a7c65d2162b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15820067:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a24bb854622121f78d7827e683920d2e |
| ToxValDB_ECHA_IUCLID | NOAEL | =2948.4 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab8e4b0a7c65d22336c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15847973:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_64424b1158080f5d68b3cd2f96839f79 |
| ToxValDB_ECHA_IUCLID | NOAEL | =3197.4 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab8e4b0a7c65d22336c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15848787:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7b1c9b97b115d8186b75ff7bb17bcfe0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2388 | mg/kg bw/day | Rat | oral | chronic; 52 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab6e4b0a7c65d2231b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835092_15849219:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_33470021801b1387974ac1507c3b483d |
| ToxValDB_ECHA_IUCLID | NOEL | =1253 | mg/kg bw/day | Rat | oral | chronic; 52 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab6e4b0a7c65d2231b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835092_15849219:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03ffe2b3e6db07f8c7cf3daa44c222df |
| ToxValDB_ECHA_IUCLID | NOEL | =2826 | mg/kg bw/day | Rat | oral | chronic; 52 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab6e4b0a7c65d2231b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/6822?documentUUID=25950578-0b18-4867-8250-14c38c87901f; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849218:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e3af9552a0af485c6d5d63bd085ed5be |