Is Capsicum Annuum Fruit Extract safe in cosmetics?
Capsicum Annuum Fruit Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Capsicum Annuum Fruit Extract
INCI: CAPSICUM ANNUUM FRUIT EXTRACT
Capsicum Annuum Fruit Extract (CAS 84625-29-6) is a cosmetic cosmetic ingredient functioning as Skin protecting, antioxidant, antimicrobial, astringent, hair conditioning,. Reported NOAEL =2052 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 84625-29-6 →
Function
Skin protecting, antioxidant, antimicrobial, astringent, hair conditioning, anti-dandruff
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
EC Number
283-403-6
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR (2007) concluded safe when formulated not to be irritating; no FDA cosmetic prohibition; capsaicin component is GRAS for food (FEMA 2266)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Capsicum Annuum Fruit Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Capsicum Annuum Fruit Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2052 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =2324 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =2388 mg/kg bw/day | oral | Rat | chronic | ECHA |
| NOAEL | =2948.4 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =3197.4 mg/kg bw/day | oral | Rat | subchronic | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-dandruff
Antioxidant
Astringent
Biocide
Humectant
No specific technical function
Softener and conditioner
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Editorial summary
Preliminary editorial summary for Capsicum Annuum Fruit Extract — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
formulate-to-avoid-irritation
capsaicin-penetration-enhancer
avoid-mucous-membranes
low-concentration-use
eu_children_restricted
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Capsicum Annuum Fruit Extract by CAS number or substance name.
Studies
5
Lowest NOAEL
2052 mg/kg bw/day
Highest NOAEL
3197 mg/kg bw/day
ECHA
Chemical Function
Biocide
Antioxidant
Humectant
Astringent
Deodorizer
Softener and conditioner
Regulatory Lists
children
Europe
Personal care
children
Europe
Personal care - dental care - toothpaste
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Bell pepper extract
Food Category
preservative
Frequently Asked Questions
Is Capsicum Annuum Fruit Extract allowed in the EU?
Capsicum Annuum Fruit Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Capsicum Annuum Fruit Extract do in cosmetics?
Capsicum Annuum Fruit Extract functions as: Skin protecting, antioxidant, antimicrobial, astringent, hair conditioning, anti-dandruff. It is classified as a cosmetic ingredient in our database. CAS number: 84625-29-6.
What is the NOAEL for Capsicum Annuum Fruit Extract?
The NOAEL (No Observed Adverse Effect Level) for Capsicum Annuum Fruit Extract is =2052 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 5 study endpoints are available. Source: ECHA.
Is Capsicum Annuum Fruit Extract used outside cosmetics?
Capsicum Annuum Fruit Extract also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Capsicum Annuum Fruit Extract compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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