Carica Papaya Fruit Extract

INCI: CARICA PAPAYA FRUIT EXTRACT

CAS Number
84012-30-6
Function
Skin conditioning agent; maintains skin in good condition; mild exfoliating and brightening properties via papain enzyme content
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restrictions; used in 172+ cosmetic products per VCRP data; not an OTC drug ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR Expert Panel (2025) concluded Carica Papaya Fruit Extract is safe in cosmetics at current practices of use and concentration. EWG Skin Deep rates LOW hazard across cancer, allergies/immunotoxicity, developmental/reproductive toxicity, and use restrictions. Minor concern for papain enzyme impurity potential allergenicity.

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Concern Level: Low

Regulatory Flags

plant-derived skin-conditioning enzyme-source papain-impurity-flag ewg-verified-restricted ige-sensitization-potential no-eu-restriction cir-safe-2025

Frequently Asked Questions

Is Carica Papaya Fruit Extract safe in cosmetics?

CIR Expert Panel (2025) concluded Carica Papaya Fruit Extract is safe in cosmetics at current practices of use and concentration. EWG Skin Deep rates LOW hazard across cancer, allergies/immunotoxicity, developmental/reproductive toxicity, and use restrictions. Minor concern for papain enzyme impurity potential allergenicity. The EU classifies Carica Papaya Fruit Extract as "permitted". Safety rating: GOOD.

Is Carica Papaya Fruit Extract allowed in the EU?

Carica Papaya Fruit Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Carica Papaya Fruit Extract do in cosmetics?

Carica Papaya Fruit Extract functions as: Skin conditioning agent; maintains skin in good condition; mild exfoliating and brightening properties via papain enzyme content. It is classified as a cosmetic ingredient in our database. CAS number: 84012-30-6.

What is the Margin of Safety for Carica Papaya Fruit Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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