Carnosol

INCI: CARNOSOL

CAS Number
5957-80-2
Function
Antioxidant; Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA premarket approval required for cosmetics; carnosol is not listed among FDA prohibited or restricted cosmetic ingredients. Rosmarinus officinalis-derived ingredients including carnosol were assessed safe by the CIR Expert Panel (2018) when formulated to be non-sensitizing.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Carnosol is a phenolic diterpene antioxidant isolated from rosemary and sage, functioning as a potent free radical scavenger with anti-inflammatory and antimicrobial properties. It is permitted in the EU and not FDA-restricted. The 2018 CIR safety assessment concluded rosemary-derived ingredients are safe when formulated to be non-sensitizing, with rosemary leaf extract restricted to 0.2% in leave-on products. The primary safety concern is confirmed sensitization potential—carnosol is the identified allergen responsible for documented cases of allergic contact dermatitis from rosemary. Adequate margin of safety is achievable at typical cosmetic concentrations, but sensitization risk must be managed through appropriate formulation design and concentration limits.

⚠️
Concern Level: Moderate

Regulatory Flags

confirmed-sensitizer contact-dermatitis-risk lamiaceae-cross-reactivity antioxidant anti-inflammatory rosemary-derived cir-assessed-as-part-of-rosemary-complex limited-standalone-safety-data occupational-allergen

Frequently Asked Questions

Is Carnosol safe in cosmetics?

Carnosol is a phenolic diterpene antioxidant isolated from rosemary and sage, functioning as a potent free radical scavenger with anti-inflammatory and antimicrobial properties. It is permitted in the EU and not FDA-restricted. The 2018 CIR safety assessment concluded rosemary-derived ingredients are safe when formulated to be non-sensitizing, with rosemary leaf extract restricted to 0.2% in leave-on products. The primary safety concern is confirmed sensitization potential—carnosol is the identified allergen responsible for documented cases of allergic contact dermatitis from rosemary. Adequate margin of safety is achievable at typical cosmetic concentrations, but sensitization risk must be managed through appropriate formulation design and concentration limits. The EU classifies Carnosol as "permitted". Safety rating: MODERATE.

Is Carnosol allowed in the EU?

Carnosol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Carnosol do in cosmetics?

Carnosol functions as: Antioxidant; Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5957-80-2.

What is the Margin of Safety for Carnosol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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