NOAEL Studies Cosmetic Ingredient

Carrageenan NOAEL Studies

INCI: CARRAGEENAN

CAS: 53973-98-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 NSRL SQE1200 ug/day - - 1988-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE1200 ug/day - - 1988-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE1200 ug/day - - 1988-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 NSRL SQE1200 ug/day - - 1988-01-01 No significant risk level {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing SQEcancer listing type - - 1988-01-01 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"1988-01-01","listing_mechanism":"SQE","madl":null,"nsrl":"1200","source_table":"prop65_listings"}
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =7500 mg/kg bw/day Rat oral: feed - chronic/long term toxicity EFSA ANS - 2018 - OutputID 3049 - histopathology non neoplastic - hepatotoxicity - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =7500 mg/kg bw/day Rat oral: feed - chronic/long term toxicity EFSA ANS - 2018 - OutputID 3049 - histopathology non neoplastic - hepatotoxicity - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =75 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2018 - OutputID 3049 - Consumers - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =75 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2018 - OutputID 3049 - Consumers - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 2B IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"31, Sup 7"}
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 2 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=8644; Record_ID=cancer_2070; Data_Type=WOE; Formulation_Name=Carrageenan, acid-degraded; Mixture=Chemical; DTXSID=DTXSID8020254; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/49; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020254
openFDA substances 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}
openFDA substances FDA UNII substance identifier 5C69YCD2YJ UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"5C69YCD2YJ"}