NOAEL Studies
Cosmetic Ingredient
Carrageenan NOAEL Studies
INCI: CARRAGEENAN
CAS: 53973-98-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQE1200 | ug/day | - | - | 1988-01-01 | No significant risk level | - |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-01-01 | California Proposition 65 listing | - |
EFSA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =7500 | mg/kg bw/day | Rat | oral: feed | - | chronic/long term toxicity | EFSA ANS - 2018 - OutputID 3049 - histopathology non neoplastic - hepatotoxicity - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238 |
| EFSA | ADI (group) | =75 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2018 - OutputID 3049 - Consumers - Re-evaluation of carrageenan (E 407) and processed Eucheuma seaweed (E 407a) as food additives - doi:10.2903/j.efsa.2018.5238 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1987 | IARC Monographs | - |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=8644; Record_ID=cancer_2070; Data_Type=WOE; Formulation_Name=Carrageenan, acid-degraded; Mixture=Chemical; DTXSID=DTXSID8020254; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/49; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8020254 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5C69YCD2YJ | UNII | - | - | - | mixture | - |