NOAEL Studies
Surfactant
Cetrimonium Chloride NOAEL Studies
INCI: CETRIMONIUM CHLORIDE
CAS: 112-02-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =450 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1152; row=10440; data_type=In Vivo; mixture=Chemical; chemical_name=Hexadecyl trimethyl ammonium chloride; preferred_name=Hexadecyl trimethyl ammonium chloride; dtxsid=DTXSID6026901; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026901; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =699 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1153; row=10439; data_type=In Vivo; mixture=Chemical; chemical_name=Hexadecyl trimethyl ammonium chloride; preferred_name=Hexadecyl trimethyl ammonium chloride; dtxsid=DTXSID6026901; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026901; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =861 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_1154; row=10441; data_type=In Vivo; mixture=Chemical; chemical_name=Hexadecyl trimethyl ammonium chloride; preferred_name=Hexadecyl trimethyl ammonium chloride; dtxsid=DTXSID6026901; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026901; source_file=acute_oral.xlsx |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | TER | 0.9 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4232; Record_ID=skin_irritation_invitro_2474; Data_Type=In Vitro; Formulation_ID=MIX778; Formulation_Name=Arquad 16-50; Percent_Active_Ingredient=50; Mixture=Mixture; DTXSID=DTXSID6026901; Assay=TER Corrosion; Endpoint=TER; Response=0.9; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026901 |
| NTP ICE skin irritation | TER | 1.1 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4227; Record_ID=skin_irritation_invitro_2473; Data_Type=In Vitro; Formulation_ID=MIX778; Formulation_Name=Arquad 16-50; Percent_Active_Ingredient=50; Mixture=Mixture; DTXSID=DTXSID6026901; Assay=TER Corrosion; Endpoint=TER; Response=1.1; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026901 |
SCCS Opinion 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.052 | mg/kg bw/day | rat | oral | - | NOAEL study | p.54 |
| SCCS Opinion | NOAEL | =0.8 | mg/kg | rat | oral | - | developmental toxicity | p.34 |
| SCCS Opinion | NOAEL | =2.5 | % | rat | dermal | - | developmental toxicity | p.33 |
| SCCS Opinion | NOAEL | =3.3 | - | - | - | - | NOAEL study | p.54 |
| SCCS Opinion | NOAEL | =9.9 | % | - | dermal | - | developmental toxicity | p.42 |
| SCCS Opinion | NOAEL | =10 | mg/kg | rat | oral | 1-year | reproductive toxicity | p.39 |
| SCCS Opinion | NOAEL | =10 | mg/kg bw/day | - | oral | 28-day | irritation | Ref.: 34 (= pp, p.35 |
| SCCS Opinion | NOAEL | =12.5 | mg/kg bw/day | rat | dermal | developmental | developmental toxicity | Ref.: 41 (= pp, p.41 |
| SCCS Opinion | NOAEL | =24 | % | rabbit | dermal | 28-day | irritation | Ref.: 33 B, p.35 |
| SCCS Opinion | NOAEL | =40 | - | rat | dermal | Developmental | developmental toxicity | p.55 |
| SCCS Opinion | NOAEL | =41 | - | - | - | - | developmental toxicity | p.41 |
| SCCS Opinion | NOAEL | =42 | - | - | - | - | developmental toxicity | p.42 |
| SCCS Opinion | NOAEL | =45 | mg/kg | rat | oral | 28-day | irritation | p.39 |
| SCCS Opinion | NOAEL | =54 | - | - | - | - | NOAEL study | p.54 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rabbit | dermal | Subacute | repeated dose toxicity | p.26 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rat | oral | 28-day | irritation | p.39 |
| SCCS Opinion | NOAEL | =100 | mg/kg/day | rat | oral | 1-year | reproductive toxicity | p.39 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/day | rat | oral | 28-day | repeated dose toxicity | p.55 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =10 | mg/kg bw/day | Rabbit | dermal | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f08e4b096bca877c1b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10710/7/6/4?documentUUID=df38ce97-5012-4cd1-8ee2-d5c3508f6e8b; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15826728:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce3d3371c9c5a37d443122820255266b |
| ECHA | NOEL | ~40 | mg/kg bw/day | Rabbit | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f12d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10710/7/9/3?documentUUID=df38ce97-5012-4cd1-8ee2-d5c3508f6e8b; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821800:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09623835eed21ef3f8db63c3e57c20f3 |
| ECHA | NOEL | ~100 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebde4b0a7c65d1cab82; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14334?documentUUID=d22bd67a-3932-4249-a7a3-4f65c137d867; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15833159:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff29f572e898dfc87d7732c40be53891 |
ToxValDB ECOTOX 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =400 | mg/kg bw/day | Mouse | oral | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc.#88-920006818:21 p. Proctor and Gamble Co. Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments 1992; TITLE=Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments; AUTHOR=Proctor and Gamble Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81224; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600180_15600181_15600182:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e503ff4fa2b6a48efda974b352c1c46b |
| ToxValDB ECOTOX | LOEL | =600 | mg/kg bw/day | Mouse | oral | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc.#88-920006818:21 p. Proctor and Gamble Co. Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments 1992; TITLE=Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments; AUTHOR=Proctor and Gamble Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81224; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Behavior: Righting response|Intoxication: Ataxia; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600180_15600181_15600182:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b6988e034ac5aeffc90cb2868f894dde |
| ToxValDB ECOTOX | NOEL | =300 | mg/kg bw/day | Mouse | oral | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc.#88-920006818:21 p. Proctor and Gamble Co. Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments 1992; TITLE=Initial Submission: Letter from Procter & Gamble Company to U.S.EPA Submitting Information on the Enclosed Ammonium Compounds & Alkylethoxylates Report with Attachments; AUTHOR=Proctor and Gamble Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81224; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Behavior: Behavioral changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600180_15600181_15600182:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c6178a23e591abe6d6fbddafcb03c87e |
Regulatory source 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | =0.052 | mg/kg bw/day | rat | oral | - | - | p.54 |
| Regulatory source | - | 3.3 | - | - | - | - | - | p.54 |
| Regulatory source | - | =10 | mg/kg bw/day | rat | oral | - | - | p.54 |
| Regulatory source | - | 54 | - | - | - | - | - | p.54 |
| Regulatory source | developmental toxicity | 0.8 | mg/kg | rat | oral | - | developmental toxicity | p.34 |
| Regulatory source | developmental toxicity | 2.5 | % | rat | dermal | - | developmental toxicity | p.33 |
| Regulatory source | developmental toxicity | 9.9 | % | - | dermal | - | developmental toxicity | p.42 |
| Regulatory source | developmental toxicity | 10 | mg/kg bw/day | rat | oral | chronic | developmental toxicity | p.55 |
| Regulatory source | developmental toxicity | 12.5 | mg/kg bw/day | rat | dermal | developmental | developmental toxicity | p.41 |
| Regulatory source | developmental toxicity | 40 | - | rat | dermal | Developmental | developmental toxicity | p.55 |
| Regulatory source | developmental toxicity | 41 | - | - | - | - | developmental toxicity | p.41 |
| Regulatory source | developmental toxicity | 42 | - | - | - | - | developmental toxicity | p.42 |
| Regulatory source | irritation | 10 | mg/kg bw/day | - | oral | 28-day | irritation | p.35 |
| Regulatory source | irritation | 10 | mg/kg bw/day | - | - | - | irritation | p.35 |
| Regulatory source | irritation | 24 | % | rabbit | dermal | 28-day | irritation | p.35 |
| Regulatory source | irritation | 45 | mg/kg | rat | oral | 28-day | irritation | p.39 |
| Regulatory source | irritation | 100 | mg/kg | rat | oral | 28-day | irritation | p.39 |
| Regulatory source | repeated dose toxicity | 10 | mg/kg bw/day | rat | oral | 28-day | repeated dose toxicity | p.55 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw/day | rabbit | dermal | Subacute | repeated dose toxicity | p.26 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg bw/day | rat | oral | 28-day | repeated dose toxicity | p.55 |
| Regulatory source | reproductive toxicity | 10 | mg/kg | rat | oral | 1-year | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 100 | mg/kg/day | rat | oral | 1-year | reproductive toxicity | p.39 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | UC9PE95IBP | UNII | - | - | - | chemical | - |