NOAEL Studies Cosmetic Ingredient

Cetylpyridinium Chloride NOAEL Studies

INCI: CETYLPYRIDINIUM CHLORIDE

CAS: 123-03-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 0.09 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3716; Record_ID=acute_inhalation_1149; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6041761; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.09; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041761
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1847; row=10839; data_type=In Vivo; mixture=Chemical; chemical_name=Cetylpyridinium chloride; preferred_name=Cetylpyridinium chloride; dtxsid=DTXSID6041761; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6041761; source_file=acute_oral.xlsx
SCCS Opinion 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =2.5 mg/kg bw/day - oral 6-month NOAEL study p.47
SCCS Opinion NOAEL <5 mg/kg bw/day - - - NOAEL study p.26
SCCS Opinion NOAEL =10 % - oral - dermal absorption p.48
SCCS Opinion NOAEL =15 mg/kg bw/day - - - NOAEL study p.30
SCCS Opinion NOAEL =15 mg/kg/day rat oral 6-month developmental toxicity p.50
SCCS Opinion NOAEL =18 mg/kg bw/day rat oral 90-day repeated dose toxicity p.31
SCCS Opinion NOAEL =25 mg/kg bw/day - - - irritation p.24
SCCS Opinion NOAEL =50 % - oral 6-month NOAEL study p.47
SCCS Opinion NOAEL =60 mg/kg bw/day - - developmental developmental toxicity p.37
SCCS Opinion NOAEL =60 mg/kg/day rat oral 6-month developmental toxicity p.50
SCCS Opinion NOAEL =74 - - - - NOAEL study p.47
SCCS Opinion NOAEL =90 - rat - 90-day NOAEL study Ref.: 24), p.30
SCCS Opinion NOAEL =100 mg/kg bw/day rat - - developmental toxicity p.39
SCCS Opinion NOAEL =113 - - - - NOAEL study p.48
SCCS Opinion NOAEL =120 - - - - NOAEL study p.47
SCCS Opinion NOAEL =156 - - - - NOAEL study p.47
SCCS Opinion NOAEL =192 - - - - NOAEL study p.47
SCCS Opinion NOAEL =205 - - - - NOAEL study p.48
SCCS Opinion NOAEL =250 mg/kg bw/day - - - NOAEL study p.26
SCCS Opinion NOAEL =250 ppm rat oral 90 days NOAEL study Ref.: 24), p.31
SCCS Opinion NOAEL =360 - - - - NOAEL study p.48
SCCS Opinion NOAEL =500 - - - - NOAEL study p.47
SCCS Opinion NOAEL =1000 ppm rat oral 90-day NOAEL study Ref.: 24), p.30
SCCS Opinion NOAEL =1385 - - - - NOAEL study p.48
SCCS Opinion NOAEL =1875 - - - - NOAEL study p.48
SCCS Opinion NOAEL =41700 - - - - NOAEL study p.47
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b61a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17221/7/9/2?documentUUID=8af45a8d-cd61-4f45-9732-360361e5cf57; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15862602:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_de110d8abdc40f6aab9e99ef6363bb6b
ECHA NOAEL =12 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17221/7/9/3?documentUUID=8af45a8d-cd61-4f45-9732-360361e5cf57; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15824144:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5fcb189464d8c97778aff3bb6930d3c6
ECHA NOAEL >25 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbeaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17221/7/9/3?documentUUID=8af45a8d-cd61-4f45-9732-360361e5cf57; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15824145:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_97c5a0808475d9b333f121986e98ab9b
ECHA NOEL =25 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead1be4b0a7c65d1c2837; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17221/7/6/2?documentUUID=8af45a8d-cd61-4f45-9732-360361e5cf57; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15850594:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_da5d6b7e9dadbd97571b97e40e2e801d
Regulatory source 44 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 2.5 mg/kg bw/day - oral 6-month - p.47
Regulatory source - <5 mg/kg bw/day - - - - p.26
Regulatory source - 5 mg/kg bw/day - oral 6-month - p.47
Regulatory source - <5 mg/kg bw/day rat oral 28-day - p.49
Regulatory source - 5 mg/kg bw/day rat oral 6-month - p.49
Regulatory source - 15 mg/kg bw/day - - - - p.30
Regulatory source - 18 mg/kg bw/day rat oral 90-day - p.32
Regulatory source - 25 mg/kg bw/day - - - - p.24
Regulatory source - 50 % - oral 6-month - p.47
Regulatory source - 50 % - oral - - p.47
Regulatory source - 74 - - - - - p.47
Regulatory source - 90 - rat - 90-day - p.30
Regulatory source - 113 - - - - - p.48
Regulatory source - 120 - - - - - p.47
Regulatory source - 156 - - - - - p.47
Regulatory source - 192 - - - - - p.47
Regulatory source - 205 - - - - - p.48
Regulatory source - 250 mg/kg bw/day - - - - p.26
Regulatory source - 250 ppm rat oral 90 days - p.31
Regulatory source - 360 - - - - - p.48
Regulatory source - 500 - - - - - p.47
Regulatory source - 1000 ppm rat oral 90-day - p.30
Regulatory source - 1385 - - - - - p.48
Regulatory source - 1875 - - - - - p.48
Regulatory source - 41700 - - - - - p.47
Regulatory source dermal absorption 10 % - oral - dermal absorption p.48
Regulatory source dermal absorption 10 % - dermal - dermal absorption p.48
Regulatory source dermal absorption 18 mg/kg bw/day - oral - dermal absorption p.48
Regulatory source dermal absorption 50 % - oral - dermal absorption p.48
Regulatory source developmental toxicity 5 mg/kg bw/day rat oral 6-month developmental toxicity p.50
Regulatory source developmental toxicity 15 mg/kg/day rat oral 6-month developmental toxicity p.50
Regulatory source developmental toxicity 60 mg/kg bw/day - - developmental developmental toxicity p.37
Regulatory source developmental toxicity 60 mg/kg/day rat oral 6-month developmental toxicity p.50
Regulatory source developmental toxicity 100 mg/kg bw/day rat - - developmental toxicity p.39
Regulatory source genotoxicity 5 mg/kg bw/day - oral 6-month genotoxicity p.32
Regulatory source irritation 18 mg/kg bw/day rat oral 90-day irritation p.50
Regulatory source irritation 25 mg/kg bw/day - - - irritation p.24
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral subchronic repeated dose toxicity p.30
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral 6-month repeated dose toxicity p.31
Regulatory source repeated dose toxicity 18 mg/kg bw/day rat oral 90-day repeated dose toxicity p.31
Regulatory source repeated dose toxicity 18 mg/kg bw/day rat oral sub-acute repeated dose toxicity p.32
Regulatory source repeated dose toxicity 18 mg/kg bw/day - oral sub-acute repeated dose toxicity p.50
Regulatory source repeated dose toxicity 25 mg/kg bw/day rat oral sub-acute repeated dose toxicity p.32
Regulatory source repeated dose toxicity 25 mg/kg bw/day rat oral 90-day repeated dose toxicity p.50
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6BR7T22E2S UNII - - - chemical -