NOAEL Studies Preservative

Chlorhexidine NOAEL Studies

INCI: CHLORHEXIDINE

CAS: 55-56-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 8.88 mg/kg bw/day rat oral: drinking water - chronic toxicity: oral dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=da8688af-2f4d-4191-940e-484d43399b5f_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=da8688af-2f4d-4191-940e-484d43399b5f/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-02-01; basis=other:; key_result=false; entry_uuid=9017142d-3b62-4215-a391-7896ce40d46b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=a71cdd0e-9c29-453d-935f-fbb1b809dfd7
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 8.88 mg/kg bw/day rat oral: drinking water - chronic toxicity: oral dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=da8688af-2f4d-4191-940e-484d43399b5f_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=da8688af-2f4d-4191-940e-484d43399b5f/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-02-01; basis=other:; key_result=false; entry_uuid=9017142d-3b62-4215-a391-7896ce40d46b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=a71cdd0e-9c29-453d-935f-fbb1b809dfd7
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 8.88 mg/kg bw/day rat oral: drinking water - chronic toxicity: oral dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=da8688af-2f4d-4191-940e-484d43399b5f_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=da8688af-2f4d-4191-940e-484d43399b5f/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-02-01; basis=other:; key_result=false; entry_uuid=9017142d-3b62-4215-a391-7896ce40d46b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=a71cdd0e-9c29-453d-935f-fbb1b809dfd7
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOEL 0.89 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=b69875fe-ea58-4fa7-8f85-71360a2612b3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOEL 0.89 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=b69875fe-ea58-4fa7-8f85-71360a2612b3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOEL 0.89 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=b69875fe-ea58-4fa7-8f85-71360a2612b3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=08e63377-8b11-4328-bb17-cbfaf704d1d2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >100 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=96236624-c3ff-4da3-b8fc-d296013c5211
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 0.18 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=3461f139-e884-42f4-bde9-9a1e9fc0ebe3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=08e63377-8b11-4328-bb17-cbfaf704d1d2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >100 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=96236624-c3ff-4da3-b8fc-d296013c5211
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 0.18 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=3461f139-e884-42f4-bde9-9a1e9fc0ebe3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=08e63377-8b11-4328-bb17-cbfaf704d1d2
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL >100 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=44f03d8d-76fc-4be8-ad52-1aafe4240694_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=44f03d8d-76fc-4be8-ad52-1aafe4240694/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2007; ReportDate=2007-10-10; basis=other:; key_result=false; entry_uuid=96236624-c3ff-4da3-b8fc-d296013c5211
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 0.18 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=10208f3a-130e-4b37-8f8c-c718a82f4726_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=10208f3a-130e-4b37-8f8c-c718a82f4726/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-11-05; basis=other:; key_result=false; entry_uuid=3461f139-e884-42f4-bde9-9a1e9fc0ebe3
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 360 mg/kg bw/day rabbit - - sub-chronic toxicity: dermal dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=90f51522-77ac-4460-98e1-d36b3a0fe044_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=90f51522-77ac-4460-98e1-d36b3a0fe044/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=868185c5-086b-49b6-9ad0-f120f1fb1865
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 360 mg/kg bw/day rabbit - - sub-chronic toxicity: dermal dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=90f51522-77ac-4460-98e1-d36b3a0fe044_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=90f51522-77ac-4460-98e1-d36b3a0fe044/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=868185c5-086b-49b6-9ad0-f120f1fb1865
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOEL 360 mg/kg bw/day rabbit - - sub-chronic toxicity: dermal dossier=4d34f7c5-264f-4206-9261-f6b5af208d28.i6z; document=90f51522-77ac-4460-98e1-d36b3a0fe044_4d34f7c5-264f-4206-9261-f6b5af208d28.i6d; document_key=90f51522-77ac-4460-98e1-d36b3a0fe044/4d34f7c5-264f-4206-9261-f6b5af208d28; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1988; basis=other:; key_result=false; entry_uuid=868185c5-086b-49b6-9ad0-f120f1fb1865
NTP_ICE_acute_oral 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >1430 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity record_id=acute_oral_7571; row=4447; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1180 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7569; row=4448; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <3180 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity record_id=acute_oral_7581; row=4449; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7585; row=4450; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <4239 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity record_id=acute_oral_7583; row=4451; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3055 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7579; row=4452; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2292 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7577; row=4453; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1710 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7573; row=4454; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >1870 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity record_id=acute_oral_7575; row=4455; data_type=In Vivo; mixture=Chemical; chemical_name=Chlorhexidine; preferred_name=Chlorhexidine; dtxsid=DTXSID2033314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2033314; source_file=acute_oral.xlsx
NTP_ICE_eye_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=851; Record_ID=eye_irritation_47; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2033314; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2033314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2033314
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier R4KO0DY52L UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H30Cl2N10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R4KO0DY52L"}
openFDA substances FDA UNII substance identifier R4KO0DY52L UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H30Cl2N10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R4KO0DY52L"}
openFDA substances FDA UNII substance identifier R4KO0DY52L UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H30Cl2N10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R4KO0DY52L"}
openFDA substances FDA UNII substance identifier R4KO0DY52L UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H30Cl2N10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R4KO0DY52L"}