NOAEL Studies
Cosmetic Ingredient
Chlorine Dioxide NOAEL Studies
INCI: CHLORINE DIOXIDE
CAS: 10049-04-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =0.827612 | mg/m3 | Rat (Wistar; unknown) | inhalation | subchronic; 2 months | subchronic | ATSDR MRLs; row_hash=5071c7c894f4af0d; source_hash=ToxValhc_811806491b3765a1fdf220b0f36ecc77; raw_endpoint_type=LOAEL (HEC); raw_endpoint_subtype=; raw_value=0.3; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Paulet G, Desbrousses S. 1972. On the toxicology of chlorine dioxide. Arch Mal Prof 33(1- 2):59-61.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c4b |
| Regulatory source | LOAEL | =2.7587 | mg/m3 | Rat (Wistar; unknown) | inhalation | subchronic; 2 months | subchronic | ATSDR MRLs; row_hash=4cad8498077c2daf; source_hash=ToxValhc_98ec239fc55488b2ac5d81c6f9db4d88; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=1; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Paulet G, Desbrousses S. 1972. On the toxicology of chlorine dioxide. Arch Mal Prof 33(1- 2):59-61.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c4b |
| Regulatory source | LOAEL (HEC) | =0.64 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=cacb83ee9ed8c878; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL (HEC): 6.4e-1 mg/m^3; system=Respiratory, Cardiovascular; basis=Vascular congestion and peribronchial edema; point_of_departure=LOAEL (HEC): 6.4e-1 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID5023958; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; rfc_last_updated=10/12/2000; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0496_summary.pdf |
| Regulatory source | RfC | =0.0002 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=e0423ce90bf9107d; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=2e-4; system=Respiratory, Cardiovascular; basis=Vascular congestion and peribronchial edema; point_of_departure=LOAEL (HEC): 6.4e-1 mg/m^3; composite_uf=3000; confidence=Low; dtxsid=DTXSID5023958; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; rfc_last_updated=10/12/2000; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0496_summary.pdf |
| Regulatory source | NOAEL | =3 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=5334b55567290cc9; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 3 mg/kg-day; system=Nervous, Developmental; basis=Neurodevelopmental effects; point_of_departure=NOAEL : 3 mg/kg-day; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID5023958; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; rfd_last_updated=10/12/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0496_summary.pdf |
| Regulatory source | RfD | =0.03 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=15ea6a122006ee62; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-2; system=Nervous, Developmental; basis=Neurodevelopmental effects; point_of_departure=NOAEL : 3 mg/kg-day; composite_uf=100; confidence=Medium/High; dtxsid=DTXSID5023958; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; rfd_last_updated=10/12/2000; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0496_summary.pdf |
COSMOS DB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 0.1 | mg/kg bw/day | rat | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 0.5 | mg/kg bw/day | rat | oral | 90 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1.9 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5 | mg/kg bw/day | rat | oral | 365 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 6.8 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 56 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 12 | mg/kg bw/day | rat | oral | 95 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 14 | mg/kg bw/day | rat | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | mouse | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 40 | mg/kg bw/day | rat | oral | 365 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 120 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | mouse | oral | 365 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
WHO/JECFA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOAEL | =1 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=cicads_cicads_cicad37; title=Chlorine Dixoxide (Gas)(CICADS 37, 2002); path=mirror/documents/cicads/cicads/cicad37.htm; row_hash=d89f9f35aab90260; raw_unit=ppm; context=A NOAEL for respiratory tract effects of 1 ppm (2.8 mg/m 3 ) derived from inhalation studies in rats of up to a 2-month duration thus is based on very limited data. |
| WHO/JECFA | TDI | =0.03 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=cicads_cicads_cicad37; title=Chlorine Dixoxide (Gas)(CICADS 37, 2002); path=mirror/documents/cicads/cicads/cicad37.htm; row_hash=ca8ac4bcefd57aac; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=IPCS, based on data on chlorite, proposed an oral tolerable daily intake of 30 ug/kg body weight per day for chlorine dioxide in drinking-water (IPCS, 2000). |
NTP ICE acute dermal 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1307; Record_ID=acute_dermal_126; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1305; Record_ID=acute_dermal_126; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1306; Record_ID=acute_dermal_126; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2857; Record_ID=acute_inhalation_54; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | GHS Classification | 5 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2856; Record_ID=acute_inhalation_54; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=5; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | LC50 | 0.04 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2853; Record_ID=acute_inhalation_624; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.04; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/3/3/?documentUUID=be521ebe-b897-43a1-a93d-9f7ed7025256; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | LC50 | 0.041 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2854; Record_ID=acute_inhalation_626; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.041; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/3/3/?documentUUID=be521ebe-b897-43a1-a93d-9f7ed7025256; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | LC50 | 0.048 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2852; Record_ID=acute_inhalation_622; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.048; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/3/3/?documentUUID=be521ebe-b897-43a1-a93d-9f7ed7025256; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | LC50 | 0.089 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2855; Record_ID=acute_inhalation_628; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.089; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/3/3/?documentUUID=b0e49a55-03f2-46ad-85fb-3167bf4058e0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE acute inhalation | LC50 | >5.06 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2851; Record_ID=acute_inhalation_54; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.06; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=8796; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Chlorine dioxide; preferred_name=Chlorine dioxide; percent_active_ingredient=0.72; dtxsid=DTXSID5023958; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=8795; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Chlorine dioxide; preferred_name=Chlorine dioxide; percent_active_ingredient=0.72; dtxsid=DTXSID5023958; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12414; row=8797; data_type=In Vivo; mixture=Mixture; formulation_id=MIX122; formulation_name=Cryocide 20; chemical_name=Chlorine dioxide; preferred_name=Chlorine dioxide; percent_active_ingredient=0.72; dtxsid=DTXSID5023958; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958; source_file=acute_oral.xlsx |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1550; Record_ID=eye_irritation_488; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID274; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 2 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1031; Record_ID=skin_irritation_invivo_1047; Data_Type=In Vivo; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=2; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
NTP ICE skin sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13630; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13630; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13630; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
| NTP ICE skin sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13630; Record_ID=skin_sensitization_invivo_3868; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX122; Formulation_Name=Cryocide 20; Percent_Active_Ingredient=0.72; Mixture=Mixture; DTXSID=DTXSID5023958; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 |
ToxValDB ATSDR MRLs 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =2.7587 | mg/m3 | Rat | inhalation | subchronic; 2 months | subchronic | LONG_REF=Paulet G, Desbrousses S. 1972. On the toxicology of chlorine dioxide. Arch Mal Prof 33(1- 2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet G; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp160.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447428_15447429:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_98ec239fc55488b2ac5d81c6f9db4d88 |
| ToxValDB ATSDR MRLs | LOAEL (HEC) | =0.827612 | mg/m3 | Rat | inhalation | subchronic; 2 months | subchronic | LONG_REF=Paulet G, Desbrousses S. 1972. On the toxicology of chlorine dioxide. Arch Mal Prof 33(1- 2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet G; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c4b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp160.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447428_15447429:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_811806491b3765a1fdf220b0f36ecc77 |
| ToxValDB ATSDR MRLs | MRL | =0.00275871 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory in sex not reported rats; STUDY_GROUP=ATSDR MRLs:15446929:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce37965a31b990927e1fb8138d8a8686 |
| ToxValDB ATSDR MRLs | MRL | =0.00275871 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory in sex not reported rats; STUDY_GROUP=ATSDR MRLs:15446929:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce37965a31b990927e1fb8138d8a8686 |
ECHA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =6.9 | mg/m3 | Rat | inhalation | short-term; 30 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fe3e4b096bca877f39c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15827133:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_85a2341599a7d95c571b2523c13a66c7 |
| ECHA | LOAEC | =28 | mg/m3 | Rat | inhalation | short-term; 9 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15828715:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1b0b14d603725346ce858e15fdba8fe |
| ECHA | LOAEC | =77.2437 | mg/m3 | Rat | inhalation | subchronic; 1 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828971_15828972:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e064723c77434408048b302a836098a |
| ECHA | LOAEL | =2.8 | mg/m3 | Rat | inhalation | subchronic; 2 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15827927:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2459bc97476eeea1b67ed6e91b10fb1 |
| ECHA | LOAEL | >10 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23339/7/9/2?documentUUID=7d1af02e-c224-4ecc-8bb2-7423aec1fa12; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID:15861616:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e707c61edf110f22feae8128911bd3c3 |
| ECHA | LOAEL | =14 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/9/2?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15858909:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a06f48b826457e5b3c74d5d528684dde |
| ECHA | NOAEC | =14 | mg/m3 | Rat | inhalation | subchronic; 1 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828971_15828972:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0cb08217c183ec5987b31891407d81d2 |
| ECHA | NOAEL | =5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/9/2?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15856898:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_01ccef3ddc7d1078edaf7091575a4f2c |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b51d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/9/2?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855600_15861650:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cb3b72e897c50278e47c0db04c7ecfa9 |
| ECHA | NOAEL | =90 | mg/m3 | Rat | inhalation | short-term; 30 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15827565:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_427e5c0a02ba08632713a697fd098f5d |
| ECHA | NOAEL | =100 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22eb76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/9/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822640_15823072:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0aaf14d787ff570d88f73af4fecf8c02 |
| ECHA | NOAEL | =200 | mg/L | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9e9e4b0a7c65d21f4a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/2?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15834910:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c3bcc93932fc47018f14c425ecd2870 |
| ECHA | NOAEL | =20000 | mg/m3 | Rat | oral | - | reproduction developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218ddb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/9/2?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15858485:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e8bbee079e91551d8fb1ed57fa015ce |
| ECHA | NOEC | =0.28 | mg/m3 | Rat | inhalation | subchronic; 10 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15450/7/6/3?documentUUID=3078e739-bd97-4b1e-a1cb-b3a7ee3c5926; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15828161:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_755bd939a2668ed847f7890714a4aec3 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.304 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630643_15630644:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee3fb7ef53ff297d43fd444e034b6911 |
| ToxValDB GESTIS DNEL | DNEL systemic | =0.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630643_15630644:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ad0017c6aba9dab3e3f55abd1674358 |
ToxValDB IRIS 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =2.76 | mg/m3 | Rat | inhalation | short-term; 30 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1972) On the toxicology of chlorine dioxide. Arch Mal Prof Med Trav Secur Soc 33(1-2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=vascular congestion and peribronchial edema; STUDY_GROUP=IRIS_dup_IRIS Summary_15644564_15644565_15644566:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd9153459c6defc3a66d7e847c76cdd6 |
| ToxValDB IRIS | LOAEL | =6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=CMA (Chemical Manufacturers Association). (1996) Sodium chlorite: drinking water rat two?generation reproductive toxicity study. Quintiles Report Ref. CMA/17/11; TITLE=Sodium chlorite: drinking water rat two?generation reproductive toxicity study; AUTHOR=CMA (Chemical Manufacturers Association); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=neurodevelopmental effects; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS:15644559:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1733c521708c15cc4f21119adfca60bd |
| ToxValDB IRIS | LOAEL | =6.9 | mg/m3 | Rabbit | inhalation | subchronic; 45 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1970) On the action of ClO2 at low concentrations on laboratory animals. Arch Mal Prof Med Trav Secur Soc 31(3):97-106.; TITLE=On the action of ClO2 at low concentrations on laboratory animals; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=Hemorrhagic alveoli and congested capillaries the lungs; STUDY_GROUP=IRIS_dup_IRIS Summary_15644561_15644562_15644563:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d1678c418789bae1781630ad6ac709a5 |
| ToxValDB IRIS | LOAEL (ADJ) | =0.41 | mg/m3 | Rat | inhalation | short-term; 30 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1972) On the toxicology of chlorine dioxide. Arch Mal Prof Med Trav Secur Soc 33(1-2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=vascular congestion and peribronchial edema; STUDY_GROUP=IRIS_dup_IRIS Summary_15644564_15644565_15644566:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a036f3b49ab49bbf6f5eede9500ecda |
| ToxValDB IRIS | LOAEL (ADJ) | =0.82 | mg/m3 | Rabbit | inhalation | subchronic; 45 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1970) On the action of ClO2 at low concentrations on laboratory animals. Arch Mal Prof Med Trav Secur Soc 31(3):97-106.; TITLE=On the action of ClO2 at low concentrations on laboratory animals; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=Hemorrhagic alveoli and congested capillaries the lungs; STUDY_GROUP=IRIS_dup_IRIS Summary_15644561_15644562_15644563:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c0b5b4c2d2ba1b1e2eb7d528e43071ab |
| ToxValDB IRIS | LOAEL (HEC) | =0.49 | mg/m3 | Rabbit | inhalation | subchronic; 45 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1970) On the action of ClO2 at low concentrations on laboratory animals. Arch Mal Prof Med Trav Secur Soc 31(3):97-106.; TITLE=On the action of ClO2 at low concentrations on laboratory animals; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=Hemorrhagic alveoli and congested capillaries the lungs; STUDY_GROUP=IRIS_dup_IRIS Summary_15644561_15644562_15644563:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c8695499c0fb7db792cc9a88d6ac88f |
| ToxValDB IRIS | LOAEL (HEC) | =0.64 | mg/m3 | Rat | inhalation | short-term; 30 days | subchronic | LONG_REF=Paulet, G; Desbrousses, S. (1972) On the toxicology of chlorine dioxide. Arch Mal Prof Med Trav Secur Soc 33(1-2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=vascular congestion and peribronchial edema; STUDY_GROUP=IRIS_dup_IRIS Summary_15644564_15644565_15644566:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_62d24628bf8628d72ef58ed9e0437c08 |
| ToxValDB IRIS | NOAEL | =3 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=CMA (Chemical Manufacturers Association). (1996) Sodium chlorite: drinking water rat two?generation reproductive toxicity study. Quintiles Report Ref. CMA/17/10; TITLE=Sodium chlorite: drinking water rat two?generation reproductive toxicity study; AUTHOR=CMA (Chemical Manufacturers Association); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=neurodevelopmental effects; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS:15644558:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66a79fb82d82f29571207dd162a5cfe0 |
| ToxValDB IRIS | RfC | =0.0002 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Paulet, G; Desbrousses, S. (1972) On the toxicology of chlorine dioxide. Arch Mal Prof Med Trav Secur Soc 33(1-2):59-61.; TITLE=On the toxicology of chlorine dioxide; AUTHOR=Paulet, G; Desbrousses, S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=Vascular congestion and peribronchial edema in rats; STUDY_GROUP=IRIS:15644567:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_783035c12fad4d1e1a9df2ea5cbf8db4 |
| ToxValDB IRIS | RfD | =0.03 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=CMA (Chemical Manufacturers Association). (1996) Sodium chlorite: drinking water rat two?generation reproductive toxicity study. Quintiles Report Ref. CMA/17/12; TITLE=Sodium chlorite: drinking water rat two?generation reproductive toxicity study; AUTHOR=CMA (Chemical Manufacturers Association); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b2b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=496; TOXICOLOGICAL_EFFECT=Neurodevelopmental effects in male/female rats; STUDY_GROUP=IRIS:15644560:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_19470336737ff17d447027acbe27fb09 |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.00275869 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663259:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a49358887b84e5824c713cf1c276687 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8061YMS4RM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8061YMS4RM"} |
| openFDA substances | FDA UNII substance identifier | 8061YMS4RM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8061YMS4RM"} |
| openFDA substances | FDA UNII substance identifier | 8061YMS4RM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8061YMS4RM"} |
| openFDA substances | FDA UNII substance identifier | 8061YMS4RM | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8061YMS4RM"} |