NOAEL Studies
Cosmetic Ingredient
Chloroacetic Acid NOAEL Studies
INCI: CHLOROACETIC ACID
CAS: 79-11-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 0.18 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2319; Record_ID=acute_inhalation_2826; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.18; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
| NTP_ICE_acute_inhalation | LC50 | 0.1808 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2320; Record_ID=acute_inhalation_1870; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.1808; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
| NTP_ICE_acute_inhalation | LC50 | >1268 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2321; Record_ID=acute_inhalation_757; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1268; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15187/7/3/3/?documentUUID=422fa027-7378-4732-a008-8c62e0ae775f; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
| NTP_ICE_acute_inhalation | LC50 | >0.225 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2322; Record_ID=acute_inhalation_758; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.225; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15187/7/3/3/?documentUUID=c27680da-5ff2-4149-9814-b91a39c5c0f1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =76 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10448; row=6965; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetic acid; preferred_name=Chloroacetic acid; dtxsid=DTXSID4020901; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020901; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =55 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10444; row=6967; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetic acid; preferred_name=Chloroacetic acid; dtxsid=DTXSID4020901; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020901; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =90 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_10452; row=6968; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroacetic acid; preferred_name=Chloroacetic acid; dtxsid=DTXSID4020901; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID4020901; source_file=acute_oral.xlsx |
NTP_ICE_cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 30 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=4506; Record_ID=cancer_4123; Data_Type=In Vivo; Formulation_Name=Monochloroacetic Acid; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=30; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-396; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr396/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
| NTP_ICE_cancer | Top dose | 100 | mg/kg | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=4508; Record_ID=cancer_4122; Data_Type=In Vivo; Formulation_Name=Monochloroacetic Acid; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=100; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-396; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr396/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
NTP_ICE_skin_irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 8.5 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=2840; Record_ID=skin_irritation_invitro_76; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4020901; Assay=Corrositex; Endpoint=Breakthrough Time; Response=8.5; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020901; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020901 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =309171 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15513534:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ff554130bde2dcbe9c595f6c9dfb029 |
ToxValDB_ECHA_IUCLID 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc32f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/6/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15847737:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c7aeebfcd776d8cc8f51ee99958d5582 |
| ToxValDB_ECHA_IUCLID | LOAEL | =19 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc324; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/6/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15849903:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d473d71eb6b2ec015b4436d93802cf2a |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819233_15819234_15820231:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5d943f73823dc58c6f075b03cac2e1f |
| ToxValDB_ECHA_IUCLID | NOAEL | =15 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15820227:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8728e71f08351acde7220ef032fda0a |
| ToxValDB_ECHA_IUCLID | NOAEL | =3.5 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819194_15820230:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0fed7d42b53a90f9fa11f915b099d4c1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =193 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf196; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/9/3?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15825399:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_647d0518eea89706b129499afde79fe9 |
| ToxValDB_ECHA_IUCLID | NOAEL | =120 | mg/kg bw/day | Mouse | oral | short-term; 16 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d228052; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/6/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15848068:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_92aeab8155372a23c7281c246be365af |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc33f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/6/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15849112:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9d9379e49df324f84234ade9db8cb310 |
| ToxValDB_ECHA_IUCLID | NOAEL | =14.07 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95de4b0a7c65d21c8b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/9/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15856956:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cac0ea31507cc07b9a321bc5698cddcf |
| ToxValDB_ECHA_IUCLID | NOAEL | =7.04 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95de4b0a7c65d21c8b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/9/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15858827:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1435720d56320a829daaa8367f17ee28 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=28.15 | mg/L | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95de4b0a7c65d21c8b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/9/2?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID:15860178:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dbbdf8312ca5ddefe89d0f5ff5fa5238 |
| ToxValDB_ECHA_IUCLID | NOEL | >=80 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d2178e7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15817641:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_838f1a38ba809b48653e0d666b352507 |
| ToxValDB_ECHA_IUCLID | NOEL | >=59.9 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819194_15820230:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ac07dfb8b692e64c58f16eafb83e5cc |
| ToxValDB_ECHA_IUCLID | NOEL | >=100 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819233_15819234_15820231:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_38980bb394bcf6940295da3004423434 |
| ToxValDB_ECHA_IUCLID | NOEL | >=30 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47dc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/8244/7/8?documentUUID=a3a23654-b09f-4ac2-b9bd-33e4eb657858; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15820228:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d0635b9e39ad60580615b5d2abb27b82 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630646_15630647:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e32352f0f9d283d96a43ac55a062ca0 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630646_15630647:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_891adee38035f4b4055a41fe18233cfc |
ToxValDB_HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | NOAEL | ~25 | mg/kg bw/day | Rat | oral | chronic; 208 days | chronic | LONG_REF=Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: December 22, 2006. Hoechst AG Frankfurt 80; Hoechst AG Frankfurt/Main; Fuhrman et al.(1955): Arch. Int. Pharmacodyn. 102, 113-125.; EXTERNAL_SOURCE_ID=60235; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639570_15640129:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d72ee18b01f92d25c8bebd622871e985 |
ToxValDB_OW_Drinking_Water_Standards 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_OW_Drinking_Water_Standards | RfD | =0.01 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610036ede4b01a90a3f98ae0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/system/files/documents/2022-01/dwtable2018.pdf; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=OW Drinking Water Standards:15649316:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a394dd1e8c735af6980d61da30e52e1 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfD | =0.002 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650232:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8cb7e4acd41ccf2062802349b19c4402 |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfD | =0.0035 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15655022:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_442be05f8387e271da495fb5152b243d |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5GD84Y125G | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H3ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5GD84Y125G"} |
| openFDA substances | FDA UNII substance identifier | 5GD84Y125G | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H3ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5GD84Y125G"} |
| openFDA substances | FDA UNII substance identifier | 5GD84Y125G | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H3ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5GD84Y125G"} |
| openFDA substances | FDA UNII substance identifier | 5GD84Y125G | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H3ClO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5GD84Y125G"} |