NOAEL Studies
Cosmetic Ingredient
Chloroform NOAEL Studies
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =68.3513 | mg/m3 | Human (M/F) | inhalation | chronic; 6 months | occupational | ATSDR MRLs; row_hash=91a3b26b638c8176; source_hash=ToxValhc_83f05005daf5d3048095a5c2f037b0ea; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=14; raw_unit=ppm; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Phoon WH, Goh KT, Lee LT, et al. 1983. Toxic jaundice from occupational exposure to chloroform. Med J Malaysia 38:31-34; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55 |
| Regulatory source | NOAEL | =14.6467 | mg/m3 | Mouse (B6C3F1; F) | inhalation | short-term; 7 days | short-term | ATSDR MRLs; row_hash=a9017ba35cdba262; source_hash=ToxValhc_00b66415b058b00b9b5ac1ad202ede6f; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=3; raw_unit=ppm; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Larson JL, Wolf DC, Morgan KT, et al. 1994c. The toxicity of l-week exposures to inhaled chloroform in female B6C3F1 mice and male F-344 rats. Fund Appl Toxicol 22:431-446.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55 |
| Regulatory source | NOAEL | =26 | mg/kg/day | Mouse (B6C3F1; F) | oral | short-term; 4 days | short-term | ATSDR MRLs; row_hash=df8f1a7b7a2fdbd0; source_hash=ToxValhc_503ece377527d16953e4d5385ae09501; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=26; raw_unit=mg/kg/day; method=drinking water; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Larson JL, Wolf DC, Butterworth BE. 1994b. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3Ft mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water. Fund Appl Toxicol 22:90-102; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55 |
| Regulatory source | NOAEL | =15 | mg/kg/day | Dog (Beagle; M/F) | oral | chronic; 7.5 years | chronic | ATSDR MRLs; row_hash=fd1722d73712c075; source_hash=ToxValhc_6744791af3e91bc8ddda9d4c3d38ad0f; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=15; raw_unit=mg/kg/day; method=capsule; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Heywood R, Sortwell RJ, Noel PRB, et al. 1979. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55 |
| Regulatory source | BMDL 10 | =1 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=8f47697a49ef6f55; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 10 : 1.0 mg/kg-day; system=Hepatic; basis=Moderate/marked fatty cyst formation in the liver and elevated SGPT; point_of_departure=BMDL 10 : 1.0 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID1020306; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=25; rfd_last_updated=10/19/2001; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0025_summary.pdf |
| Regulatory source | RfD | =0.01 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=76589d8840bfdfbd; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-2; system=Hepatic; basis=Moderate/marked fatty cyst formation in the liver and elevated SGPT; point_of_departure=BMDL 10 : 1.0 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID1020306; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=25; rfd_last_updated=10/19/2001; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0025_summary.pdf |
California Proposition 65 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=40; oral=20 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=40; oral=20 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=40; oral=20 | ug/day | - | - | 1987-10-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1987-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1987-10-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=40; oral=20","source_table":"prop65_listings"} |
ECHA 124 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 15 | mg/kg bw/day | dog | oral: capsule | - | chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1863bffc-706c-42f2-8657-f3ca9ebe36de_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1863bffc-706c-42f2-8657-f3ca9ebe36de/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=b0652bb2-6b05-44f0-9bed-f2ae86037b1f |
| ECHA | LOAEL | 138 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=fcbd1908-b094-4b57-bf8c-19a0a444be46 |
| ECHA | LOAEL | 238 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=cb3c67b3-c8f3-4610-ad67-85de346301c8 |
| ECHA | LOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=c1cc7044-fe16-4ba9-80f2-6e510eb58416 |
| ECHA | LOAEL | 34 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=23221eab-5476-4a50-8fe3-33576a53dafb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=23221eab-5476-4a50-8fe3-33576a53dafb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=2800c802-ec0a-4af8-bd31-15c4ab12c5aa |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=d315b58d-b8ca-4429-bc9f-fbe58ccdfb9d |
| ECHA | LOAEL | 37 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=589e6456-80f6-4f71-83c7-e460e5012174_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=589e6456-80f6-4f71-83c7-e460e5012174/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=8b368983-010d-4fa0-b979-33aff4ca9138 |
| ECHA | LOAEL | 90 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dc1e2c68-1281-4320-91e1-6dacc65ac1cb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dc1e2c68-1281-4320-91e1-6dacc65ac1cb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=false; entry_uuid=b3db76fa-6c16-4a32-aa7a-d011eded3cd4 |
| ECHA | LOAEL | 60 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=9b47b5ae-b202-4be4-969a-6536971a53d6 |
| ECHA | LOAEL | 15 | mg/kg bw/day | dog | oral: capsule | - | chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1863bffc-706c-42f2-8657-f3ca9ebe36de_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1863bffc-706c-42f2-8657-f3ca9ebe36de/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=b0652bb2-6b05-44f0-9bed-f2ae86037b1f |
| ECHA | LOAEL | 138 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=fcbd1908-b094-4b57-bf8c-19a0a444be46 |
| ECHA | LOAEL | 238 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=cb3c67b3-c8f3-4610-ad67-85de346301c8 |
| ECHA | LOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=c1cc7044-fe16-4ba9-80f2-6e510eb58416 |
| ECHA | LOAEL | 34 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=23221eab-5476-4a50-8fe3-33576a53dafb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=23221eab-5476-4a50-8fe3-33576a53dafb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=2800c802-ec0a-4af8-bd31-15c4ab12c5aa |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=d315b58d-b8ca-4429-bc9f-fbe58ccdfb9d |
| ECHA | LOAEL | 37 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=589e6456-80f6-4f71-83c7-e460e5012174_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=589e6456-80f6-4f71-83c7-e460e5012174/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=8b368983-010d-4fa0-b979-33aff4ca9138 |
| ECHA | LOAEL | 90 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dc1e2c68-1281-4320-91e1-6dacc65ac1cb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dc1e2c68-1281-4320-91e1-6dacc65ac1cb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=false; entry_uuid=b3db76fa-6c16-4a32-aa7a-d011eded3cd4 |
| ECHA | LOAEL | 60 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=9b47b5ae-b202-4be4-969a-6536971a53d6 |
| ECHA | LOAEL | 15 | mg/kg bw/day | dog | oral: capsule | - | chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1863bffc-706c-42f2-8657-f3ca9ebe36de_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1863bffc-706c-42f2-8657-f3ca9ebe36de/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=b0652bb2-6b05-44f0-9bed-f2ae86037b1f |
| ECHA | LOAEL | 138 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=fcbd1908-b094-4b57-bf8c-19a0a444be46 |
| ECHA | LOAEL | 238 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=1377c368-046f-4a8f-b3fc-76949cc04214_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=1377c368-046f-4a8f-b3fc-76949cc04214/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=true; entry_uuid=cb3c67b3-c8f3-4610-ad67-85de346301c8 |
| ECHA | LOAEL | 150 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=c1cc7044-fe16-4ba9-80f2-6e510eb58416 |
| ECHA | LOAEL | 34 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=23221eab-5476-4a50-8fe3-33576a53dafb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=23221eab-5476-4a50-8fe3-33576a53dafb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=2800c802-ec0a-4af8-bd31-15c4ab12c5aa |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=d315b58d-b8ca-4429-bc9f-fbe58ccdfb9d |
| ECHA | LOAEL | 37 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=589e6456-80f6-4f71-83c7-e460e5012174_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=589e6456-80f6-4f71-83c7-e460e5012174/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=8b368983-010d-4fa0-b979-33aff4ca9138 |
| ECHA | LOAEL | 90 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dc1e2c68-1281-4320-91e1-6dacc65ac1cb_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dc1e2c68-1281-4320-91e1-6dacc65ac1cb/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-03-01; basis=other:; key_result=false; entry_uuid=b3db76fa-6c16-4a32-aa7a-d011eded3cd4 |
| ECHA | LOAEL | 60 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=8a60a5d2-fbb9-471c-bed1-bb0a6fca93e8/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=true; entry_uuid=9b47b5ae-b202-4be4-969a-6536971a53d6 |
| ECHA | NOAEL | 34 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=0c93f619-6a78-4431-b72c-8292fe9cf4c9_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=0c93f619-6a78-4431-b72c-8292fe9cf4c9/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=6d26f1a7-d6ce-4c70-84cb-4ed656c7c1b7 |
| ECHA | NOAEL | >=41.2 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=true; entry_uuid=760a1843-fa7a-4174-a111-bf918144ccaa |
| ECHA | NOAEL | 15.9 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=false; entry_uuid=dcf7a1a8-9c1c-462a-99d0-59770a597e43 |
| ECHA | NOAEL | 17 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e297acc4-2f1b-4ba8-987a-9c570176eea5_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e297acc4-2f1b-4ba8-987a-9c570176eea5/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=true; entry_uuid=69ce36e6-4fbb-4d94-b6dc-ec8e403460ac |
| ECHA | NOAEL | 35 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=07654ecc-daef-4792-863e-3aab084764fd |
| ECHA | NOAEL | >=50 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=d4885087-f4e2-456e-81be-a08b4d7bfe06 |
| ECHA | NOAEL | >=31.1 | mg/kg bw/day | mouse | oral: gavage | - | developmental neurotoxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=12730e38-7375-42d2-b164-fbbc5426a414_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=12730e38-7375-42d2-b164-fbbc5426a414/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=032c5ea2-65cd-4271-8f92-fe50858d654c |
| ECHA | NOAEL | 24 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=ffffbb53-8c26-4ed9-b585-90f8b740a6ce_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=ffffbb53-8c26-4ed9-b585-90f8b740a6ce/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=924c4347-3810-4ea3-bcf2-f49e54988447 |
| ECHA | NOAEL | 300 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=e2dbfcac-455a-4de4-93ec-df16962f830f |
| ECHA | NOAEL | 10 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dfbffeff-0e4d-4545-8737-e1166a255d1c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dfbffeff-0e4d-4545-8737-e1166a255d1c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a28510b7-7e1d-424d-9457-d33e88245a81 |
| ECHA | NOAEL | >=263 | mg/kg bw/day | mouse | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e0bb73ca-1c79-4663-a9e4-20f44a87fa47_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e0bb73ca-1c79-4663-a9e4-20f44a87fa47/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=16571990-78ac-4443-b278-4a8622929cee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=a78577ec-3cca-4ad3-b3a4-796ab901605a |
| ECHA | NOAEL | >=60 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=a4641fb4-1ac2-46a9-8099-cfe9b856f120 |
| ECHA | NOAEL | >=165 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=0511efa0-47cf-452e-b45e-d20f19516d9c |
| ECHA | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=5f3088a4-9764-49c7-a1cc-94c215755684_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=5f3088a4-9764-49c7-a1cc-94c215755684/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=c2fa0524-4bb5-48dd-a4cb-0d9ca6f12bbf |
| ECHA | NOAEL | 19 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=6af0317b-1f56-4e38-98f5-ec95de7317ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=6af0317b-1f56-4e38-98f5-ec95de7317ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=4f8d0968-2b81-4f4a-b478-0327dcda13bc |
| ECHA | NOAEL | >=30 | mg/kg bw/day | dog | oral: capsule | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=8977d43e-365b-4fba-97c7-e40d42add840 |
| ECHA | NOAEL | 34 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=0c93f619-6a78-4431-b72c-8292fe9cf4c9_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=0c93f619-6a78-4431-b72c-8292fe9cf4c9/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=6d26f1a7-d6ce-4c70-84cb-4ed656c7c1b7 |
| ECHA | NOAEL | >=41.2 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=true; entry_uuid=760a1843-fa7a-4174-a111-bf918144ccaa |
| ECHA | NOAEL | 15.9 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=false; entry_uuid=dcf7a1a8-9c1c-462a-99d0-59770a597e43 |
| ECHA | NOAEL | 17 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e297acc4-2f1b-4ba8-987a-9c570176eea5_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e297acc4-2f1b-4ba8-987a-9c570176eea5/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=true; entry_uuid=69ce36e6-4fbb-4d94-b6dc-ec8e403460ac |
| ECHA | NOAEL | 35 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=07654ecc-daef-4792-863e-3aab084764fd |
| ECHA | NOAEL | >=50 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=d4885087-f4e2-456e-81be-a08b4d7bfe06 |
| ECHA | NOAEL | >=31.1 | mg/kg bw/day | mouse | oral: gavage | - | developmental neurotoxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=12730e38-7375-42d2-b164-fbbc5426a414_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=12730e38-7375-42d2-b164-fbbc5426a414/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=032c5ea2-65cd-4271-8f92-fe50858d654c |
| ECHA | NOAEL | 24 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=ffffbb53-8c26-4ed9-b585-90f8b740a6ce_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=ffffbb53-8c26-4ed9-b585-90f8b740a6ce/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=924c4347-3810-4ea3-bcf2-f49e54988447 |
| ECHA | NOAEL | 300 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=e2dbfcac-455a-4de4-93ec-df16962f830f |
| ECHA | NOAEL | 10 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dfbffeff-0e4d-4545-8737-e1166a255d1c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dfbffeff-0e4d-4545-8737-e1166a255d1c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a28510b7-7e1d-424d-9457-d33e88245a81 |
| ECHA | NOAEL | >=263 | mg/kg bw/day | mouse | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e0bb73ca-1c79-4663-a9e4-20f44a87fa47_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e0bb73ca-1c79-4663-a9e4-20f44a87fa47/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=16571990-78ac-4443-b278-4a8622929cee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=a78577ec-3cca-4ad3-b3a4-796ab901605a |
| ECHA | NOAEL | >=60 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=a4641fb4-1ac2-46a9-8099-cfe9b856f120 |
| ECHA | NOAEL | >=165 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=0511efa0-47cf-452e-b45e-d20f19516d9c |
| ECHA | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=5f3088a4-9764-49c7-a1cc-94c215755684_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=5f3088a4-9764-49c7-a1cc-94c215755684/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=c2fa0524-4bb5-48dd-a4cb-0d9ca6f12bbf |
| ECHA | NOAEL | 19 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=6af0317b-1f56-4e38-98f5-ec95de7317ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=6af0317b-1f56-4e38-98f5-ec95de7317ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=4f8d0968-2b81-4f4a-b478-0327dcda13bc |
| ECHA | NOAEL | >=30 | mg/kg bw/day | dog | oral: capsule | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=8977d43e-365b-4fba-97c7-e40d42add840 |
| ECHA | NOAEL | 34 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=0c93f619-6a78-4431-b72c-8292fe9cf4c9_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=0c93f619-6a78-4431-b72c-8292fe9cf4c9/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=6d26f1a7-d6ce-4c70-84cb-4ed656c7c1b7 |
| ECHA | NOAEL | >=41.2 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=true; entry_uuid=760a1843-fa7a-4174-a111-bf918144ccaa |
| ECHA | NOAEL | 15.9 | mg/kg bw/day | mouse | oral: gavage | - | two-generation reproductive toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=993bdb06-a247-4a10-abf3-6ed307217ef7_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=993bdb06-a247-4a10-abf3-6ed307217ef7/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=other:; key_result=false; entry_uuid=dcf7a1a8-9c1c-462a-99d0-59770a597e43 |
| ECHA | NOAEL | 17 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e297acc4-2f1b-4ba8-987a-9c570176eea5_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e297acc4-2f1b-4ba8-987a-9c570176eea5/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=true; entry_uuid=69ce36e6-4fbb-4d94-b6dc-ec8e403460ac |
| ECHA | NOAEL | 35 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=07654ecc-daef-4792-863e-3aab084764fd |
| ECHA | NOAEL | >=50 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=804d9a1f-b68c-482c-b2cf-bb847808ec48_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=804d9a1f-b68c-482c-b2cf-bb847808ec48/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=d4885087-f4e2-456e-81be-a08b4d7bfe06 |
| ECHA | NOAEL | >=31.1 | mg/kg bw/day | mouse | oral: gavage | - | developmental neurotoxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=12730e38-7375-42d2-b164-fbbc5426a414_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=12730e38-7375-42d2-b164-fbbc5426a414/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=032c5ea2-65cd-4271-8f92-fe50858d654c |
| ECHA | NOAEL | 24 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=ffffbb53-8c26-4ed9-b585-90f8b740a6ce_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=ffffbb53-8c26-4ed9-b585-90f8b740a6ce/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=true; entry_uuid=924c4347-3810-4ea3-bcf2-f49e54988447 |
| ECHA | NOAEL | 300 | mg/kg bw/day | mouse | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=bc379567-3b0a-42ae-9d68-dbdd1c43d70d_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=bc379567-3b0a-42ae-9d68-dbdd1c43d70d/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=true; entry_uuid=e2dbfcac-455a-4de4-93ec-df16962f830f |
| ECHA | NOAEL | 10 | mg/kg bw/day | mouse | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=dfbffeff-0e4d-4545-8737-e1166a255d1c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=dfbffeff-0e4d-4545-8737-e1166a255d1c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a28510b7-7e1d-424d-9457-d33e88245a81 |
| ECHA | NOAEL | >=263 | mg/kg bw/day | mouse | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=e0bb73ca-1c79-4663-a9e4-20f44a87fa47_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=e0bb73ca-1c79-4663-a9e4-20f44a87fa47/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=16571990-78ac-4443-b278-4a8622929cee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=d4a801a3-09a1-4cde-ba75-9d745488039b_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=d4a801a3-09a1-4cde-ba75-9d745488039b/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=true; entry_uuid=a78577ec-3cca-4ad3-b3a4-796ab901605a |
| ECHA | NOAEL | >=60 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=a4641fb4-1ac2-46a9-8099-cfe9b856f120 |
| ECHA | NOAEL | >=165 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=a089af66-06ba-449f-963b-6a7579977762_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=a089af66-06ba-449f-963b-6a7579977762/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=0511efa0-47cf-452e-b45e-d20f19516d9c |
| ECHA | NOAEL | 25 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=5f3088a4-9764-49c7-a1cc-94c215755684_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=5f3088a4-9764-49c7-a1cc-94c215755684/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=c2fa0524-4bb5-48dd-a4cb-0d9ca6f12bbf |
| ECHA | NOAEL | 19 | mg/kg bw/day | rat | oral: drinking water | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=6af0317b-1f56-4e38-98f5-ec95de7317ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=6af0317b-1f56-4e38-98f5-ec95de7317ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=true; entry_uuid=4f8d0968-2b81-4f4a-b478-0327dcda13bc |
| ECHA | NOAEL | >=30 | mg/kg bw/day | dog | oral: capsule | - | carcinogenicity: oral | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=7bf9ce74-0ac5-4e36-a4a6-5cbc3ea544ec/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1979; basis=other:; key_result=false; entry_uuid=8977d43e-365b-4fba-97c7-e40d42add840 |
| ECHA | NOEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=a87c8c6d-0e62-4698-ae52-ee2659636e61 |
| ECHA | NOEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=a87c8c6d-0e62-4698-ae52-ee2659636e61 |
| ECHA | NOEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=55c87126-1521-4fc1-b682-7a38df456273.i6z; document=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c_55c87126-1521-4fc1-b682-7a38df456273.i6d; document_key=139bd3e7-acd1-45ee-9b64-8c6845fa7b6c/55c87126-1521-4fc1-b682-7a38df456273; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1974; basis=other:; key_result=true; entry_uuid=a87c8c6d-0e62-4698-ae52-ee2659636e61 |
| ECHA | LEL | =21970 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/3/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15798002:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29e3036d25c7064f2826ca1c44d32d29 |
| ECHA | LEL | =39057.9 | mg/m3 | Rat | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/3/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15798011:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_009580c435969aff9daaa2360b158965 |
| ECHA | LOAEC | =154.8 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15827345:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8a4f755b2423a8cba77514622229a4d |
| ECHA | LOAEC | =122.5 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827520_15827521:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70ae1121a8a411c7a1aa5b1e1a576193 |
| ECHA | LOAEC | =58.8 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828466:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dbeede115d85c4744385c5334fb33d7e |
| ECHA | LOAEC | =49.5 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828595:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a803c962853f7a11a165e272d5dd355 |
| ECHA | LOAEL | =138 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15816331:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ab6bf3806cae082a943a9f7efb3e79dd |
| ECHA | LOAEL | =238 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15816332:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cea72c5d7d42bd9e10655198e55aa5fc |
| ECHA | LOAEL | =150 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15818809:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_182fa49d7310c8fbcd817f0a573d93f1 |
| ECHA | LOAEL | =90 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43af; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15819299:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5aee3eb039600c81490d8988434f3373 |
| ECHA | LOAEL | >1450 | mg/L | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217103; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819949_15819950:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4f1c5d3ec546a7fa2ef46934e456d18b |
| ECHA | LOAEL | <2900 | mg/L | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217103; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819949_15819950:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_037b2cb4a3d0b40e69613cb9a3d88f5e |
| ECHA | LOAEL | =34 | mg/kg bw/day | Mouse | oral | short-term; 3 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb87e4b0a7c65d226865; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15832153:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8e7074cb93c33ddaa67daebbe6e95f4 |
| ECHA | LOAEL | =37 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb87e4b0a7c65d226872; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15835537:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c8f75edddeda6808288555811c6b531 |
| ECHA | LOAEL | =60 | mg/kg bw/day | Mouse | oral | chronic; 94 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea4e4b0a7c65d1ca2a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15838829:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c0bb8244b6589c60151a9cde985b5e94 |
| ECHA | NOAEC | =24.4112 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217106; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15816291:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6020af540b90835e32f897b9ee69b4e4 |
| ECHA | NOAEC | =48.8223 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217113; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816780_15816781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd2f4e77ad805b68b3424be544764cb1 |
| ECHA | NOAEC | >=439.401 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217113; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816780_15816781:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ed0adedab48c61ccea9cf66ad5b6c9e |
| ECHA | NOAEC | =52.2 | mg/m3 | Rat | inhalation | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f9e4b0a7c65d230ef1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15820580:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7bbc3613981478f469edbfa8fc56b752 |
| ECHA | NOAEC | =15 | mg/m3 | Rat | inhalation | - | reproduction developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f9e4b0a7c65d230ef1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15821939:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_39127829aaa53c88e7353b7686aae530 |
| ECHA | NOAEC | =9.8 | mg/m3 | Mouse | inhalation | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828105:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01fa30bdd238cfe58e7a86eb5261907b |
| ECHA | NOAEC | =24.5 | mg/m3 | Mouse | inhalation | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828297:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_284d1981cf3d6552bbf16b7c0ff19b2a |
| ECHA | NOAEC | =49 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=kidney; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID:15828714:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5d3bd4472e360d4d0fa058afcdf5d18 |
| ECHA | NOAEL | >=1800 | mg/L | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d21710d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15816368:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40e863adf59f99d3a7e5ede8c096cb56 |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43a5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15817355:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_22f4ae0047e8b93b070b02312bda9c5a |
| ECHA | NOAEL | =19 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15817521:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_98c374dfa6f0b1f44343ce72ffcfec15 |
| ECHA | NOAEL | >=30 | mg/kg bw/day | Dog | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15817797:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0a418a53ad5d24f9d54db45480d192f |
| ECHA | NOAEL | >=60 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818375_15818376:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee5fc116980042f32136db1a9429fa95 |
| ECHA | NOAEL | >=165 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818375_15818376:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be63e9d0f105339e6398e0fe22b0d951 |
| ECHA | NOAEL | =300 | mg/kg bw/day | Mouse | injection | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c82ce4b0a7c65d217119; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15818670:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d0dbde924878da0dde71f0d5c37e5df5 |
| ECHA | NOAEL | >=263 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15819368:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12a31178c71eb4c91301a0580871fc3a |
| ECHA | NOAEL | =17 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b43b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/8?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15819415:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bba908f42c8c5ae763a9aaa203ebbfd9 |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15820674:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_72a1f27fc8a725c605eb8a3a2dbd8f33 |
| ECHA | NOAEL | =35 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15822596:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_08cafcd198f18f0f586cc61291bc5099 |
| ECHA | NOAEL | =34 | mg/kg bw/day | Rat | oral | short-term; 4 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb87e4b0a7c65d226853; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15830582:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c10d108d2a49f8a03da5aeeb88d3294 |
| ECHA | NOAEL | =76 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea4e4b0a7c65d1ca2a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15840063:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fded3e5aa90ba4ae9f4e56e67e5d67cf |
| ECHA | NOAEL | =10 | mg/kg bw/day | Mouse | oral | short-term; 21 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb88e4b0a7c65d2268ae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15844526:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a519e6adee29c8b98a3f7a91b74868ba |
| ECHA | NOAEL | =24 | mg/kg bw/day | Rat | oral | short-term; 3 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb88e4b0a7c65d2268b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15846752:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_87c6b7f48ad82959a3ea7cee00d819bb |
| ECHA | NOAEL | =100 | mg/L | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c921e4b0a7c65d21b8e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15857353:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89bf9d0caf832b50d526197541823060 |
| ECHA | NOAEL | >=41.2 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b9203; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15857560:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a13360052b0df1c85b7d52e43132a4ec |
| ECHA | NOAEL | =15.9 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b9203; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/2?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858029_15858103:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c848b13f9b8307e8b7275da94d1170b8 |
| ECHA | NOEC | =25 | mg/m3 | Mouse | inhalation | short-term; 3 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/6/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828827:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90548469f91828365340ee69d2e88129 |
| ECHA | NOEL | =20 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be5f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14963/7/9/3?documentUUID=55c87126-1521-4fc1-b682-7a38df456273; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15822019:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bdea085a168a0d5b2128bfaa65030005 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"Sup 7, 73"} |
WHO/JECFA 50 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =15 | mg/kg bw/day | Human | - | - | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=04c11b5416ca40b3; raw_unit=mg/kg body weight per day; context=Malarkey, personal communication to Health Canada, 2003). [LOAEL = 15 mg/kg body weight per day] Table 6: |
| WHO/JECFA | LOAEL | =49 | mg/m3 | Mouse | inhalation | 13 weeks | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=65a8772aa54ae730; raw_unit=mg/m 3; context=After 13 weeks, nasal effects were minimal at 49 and 147 mg/m 3 , but cell proliferation persisted at 441 mg/m 3 (Larson et al., 1996). [LOAEL = 49 mg/m 3 ] When BDF1 mice (10 per sex per exposure level) were exposed by inhalation at 0, 59, 123, 245, 490, or 980 mg/m 3 for 6 h/day, 5 days/week, for 13 weeks, the females all survived, but reduced growth and deaths occurred in males in all chloroform groups. |
| WHO/JECFA | LOAEL | =59 | mg/m3 | Rat | - | 13 weeks | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=8447921db10bfeae; raw_unit=mg/m 3; context=liver was normal in both sexes at up to 245 mg/m 3 , but cell atypia was seen in the females at 490 mg/m 3 , and swelling or necrosis occurred at 980 mg/m 3 (Kasai et al., 2002). [LOAEL = 59 mg/m 3 ] Daily exposure of male F344 rats for 6 h/day for 13 weeks resulted in mild histological changes in nasal passages at 9.8 mg/m 3 and increased cell proliferation with enhanced bone growth at 49 mg/m 3 . |
| WHO/JECFA | LOAEL | =9.8 | mg/m3 | Rat | inhalation | 5 days | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=609a6b0966e6f5de; raw_unit=mg/m 3; context=Hepatic lesions (including cell proliferation) were seen at 1470 mg/m 3 (Templin et al., 1996b). [LOAEL = 9.8 mg/m 3 ] When F344 rats (10 per sex per exposure level) were exposed by inhalation at 0, 123, 245, 490, 980, or 1960 mg/m 3 for 6 h/day, 5 days/week, for 13 weeks, growth was reduced and liver and kidney weights were increased at 245 mg/m 3 and above. |
| WHO/JECFA | LOAEL | =123 | mg/m3 | Mouse | oral | Long-term | Carcinogenicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=c67fe1a212d6d944; raw_unit=mg/m 3; context=microscopically normal at up to 245 mg/m 3 , but there were vacuolic changes in the kidneys and liver cell collapse/hepatocyte loss at 490 mg/m 3 and above (Kasai et al., 2002). [LOAEL = 123 mg/m 3 ] 8.4 Long-term exposure and carcinogenicity 8.4.1 Overview of carcinogenicity Chloroform induced liver tumours in mice (both sexes) when given by gavage in a corn oil vehicle and possibly in males when given (orally) in a toothpaste vehicle, but was not carc |
| WHO/JECFA | LOAEL | =41 | mg/kg bw/day | Rat | oral | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=0fa8032c8077b868; raw_unit=mg/kg body weight per day; context=LOAEL for toxicity = 41 mg/kg body weight per day] 8.6.2 Developmental toxicity Reduced food intake, slower growth, and fatty liver changes were seen in Sprague-Dawley rats given chloroform at 50 mg/kg body weight per day on days 6-15 of gestation by gavage in corn oil. |
| WHO/JECFA | LOAEL | =50 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=22029a06ecb778d2; raw_unit=mg/kg body weight per day; context=maternal LOAEL = 50 mg/kg body weight per day] In a similar protocol, chloroform caused maternal toxicity (slower growth and increased liver weight) when given at 100 mg/kg body weight per day and mild fetal toxicity (lower body weight), but no teratogenicity, at 400 mg/kg body weight per day (Ruddick et |
| WHO/JECFA | LOAEL | =100 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=81d29e1e042d23d6; raw_unit=mg/kg body weight per day; context=maternal LOAEL = 100 mg/kg body weight per day] Administration of chloroform at up to 50 mg/kg body weight per day by stomach tube (in corn oil) on days 6-18 of gestation resulted in reduced maternal weight gain at the top dose, but there were no dose-related effects on reproduction or fetal development ( |
| WHO/JECFA | LOAEL | =150 | mg/m3 | Rat | oral | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=e481320e48e4d307; raw_unit=mg/m 3; context=When Wistar rats were exposed to identical atmospheric concentrations, there was decreased food consumption and maternal body weight gain at 150 mg/m 3 (Hoechst, 1988). [Maternal LOAEL = 150 mg/m 3 ] At 150 mg/m 3 in both studies, fetal crown-rump length was significantly reduced, although not in a dose-related manner in the former study. |
| WHO/JECFA | LOAEL | =50 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=6ed700677e1197bd; raw_unit=mg/m 3; context=LOAEL for maternal toxicity = 50 mg/m 3 ] 8.7 Other toxicity Neat chloroform caused severe irritation when instilled into the rabbit eye (Duprat et al., 1976; |
| WHO/JECFA | LOAEL | =15 | mg/kg bw/day | Human | - | - | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=04c11b5416ca40b3; raw_unit=mg/kg body weight per day; context=Malarkey, personal communication to Health Canada, 2003). [LOAEL = 15 mg/kg body weight per day] Table 6: |
| WHO/JECFA | LOAEL | =49 | mg/m3 | Mouse | inhalation | 13 weeks | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=65a8772aa54ae730; raw_unit=mg/m 3; context=After 13 weeks, nasal effects were minimal at 49 and 147 mg/m 3 , but cell proliferation persisted at 441 mg/m 3 (Larson et al., 1996). [LOAEL = 49 mg/m 3 ] When BDF1 mice (10 per sex per exposure level) were exposed by inhalation at 0, 59, 123, 245, 490, or 980 mg/m 3 for 6 h/day, 5 days/week, for 13 weeks, the females all survived, but reduced growth and deaths occurred in males in all chloroform groups. |
| WHO/JECFA | LOAEL | =59 | mg/m3 | Rat | - | 13 weeks | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=8447921db10bfeae; raw_unit=mg/m 3; context=liver was normal in both sexes at up to 245 mg/m 3 , but cell atypia was seen in the females at 490 mg/m 3 , and swelling or necrosis occurred at 980 mg/m 3 (Kasai et al., 2002). [LOAEL = 59 mg/m 3 ] Daily exposure of male F344 rats for 6 h/day for 13 weeks resulted in mild histological changes in nasal passages at 9.8 mg/m 3 and increased cell proliferation with enhanced bone growth at 49 mg/m 3 . |
| WHO/JECFA | LOAEL | =9.8 | mg/m3 | Rat | inhalation | 5 days | Subchronic toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=609a6b0966e6f5de; raw_unit=mg/m 3; context=Hepatic lesions (including cell proliferation) were seen at 1470 mg/m 3 (Templin et al., 1996b). [LOAEL = 9.8 mg/m 3 ] When F344 rats (10 per sex per exposure level) were exposed by inhalation at 0, 123, 245, 490, 980, or 1960 mg/m 3 for 6 h/day, 5 days/week, for 13 weeks, growth was reduced and liver and kidney weights were increased at 245 mg/m 3 and above. |
| WHO/JECFA | LOAEL | =123 | mg/m3 | Mouse | oral | Long-term | Carcinogenicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=c67fe1a212d6d944; raw_unit=mg/m 3; context=microscopically normal at up to 245 mg/m 3 , but there were vacuolic changes in the kidneys and liver cell collapse/hepatocyte loss at 490 mg/m 3 and above (Kasai et al., 2002). [LOAEL = 123 mg/m 3 ] 8.4 Long-term exposure and carcinogenicity 8.4.1 Overview of carcinogenicity Chloroform induced liver tumours in mice (both sexes) when given by gavage in a corn oil vehicle and possibly in males when given (orally) in a toothpaste vehicle, but was not carc |
| WHO/JECFA | LOAEL | =41 | mg/kg bw/day | Rat | oral | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=0fa8032c8077b868; raw_unit=mg/kg body weight per day; context=LOAEL for toxicity = 41 mg/kg body weight per day] 8.6.2 Developmental toxicity Reduced food intake, slower growth, and fatty liver changes were seen in Sprague-Dawley rats given chloroform at 50 mg/kg body weight per day on days 6-15 of gestation by gavage in corn oil. |
| WHO/JECFA | LOAEL | =50 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=22029a06ecb778d2; raw_unit=mg/kg body weight per day; context=maternal LOAEL = 50 mg/kg body weight per day] In a similar protocol, chloroform caused maternal toxicity (slower growth and increased liver weight) when given at 100 mg/kg body weight per day and mild fetal toxicity (lower body weight), but no teratogenicity, at 400 mg/kg body weight per day (Ruddick et |
| WHO/JECFA | LOAEL | =100 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=81d29e1e042d23d6; raw_unit=mg/kg body weight per day; context=maternal LOAEL = 100 mg/kg body weight per day] Administration of chloroform at up to 50 mg/kg body weight per day by stomach tube (in corn oil) on days 6-18 of gestation resulted in reduced maternal weight gain at the top dose, but there were no dose-related effects on reproduction or fetal development ( |
| WHO/JECFA | LOAEL | =150 | mg/m3 | Rat | oral | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=e481320e48e4d307; raw_unit=mg/m 3; context=When Wistar rats were exposed to identical atmospheric concentrations, there was decreased food consumption and maternal body weight gain at 150 mg/m 3 (Hoechst, 1988). [Maternal LOAEL = 150 mg/m 3 ] At 150 mg/m 3 in both studies, fetal crown-rump length was significantly reduced, although not in a dose-related manner in the former study. |
| WHO/JECFA | LOAEL | =50 | mg/m3 | Rabbit | - | - | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=6ed700677e1197bd; raw_unit=mg/m 3; context=LOAEL for maternal toxicity = 50 mg/m 3 ] 8.7 Other toxicity Neat chloroform caused severe irritation when instilled into the rabbit eye (Duprat et al., 1976; |
| WHO/JECFA | LOEL | =50 | mg/kg bw/day | - | inhalation | - | Inhalation toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=226b735be70340aa; raw_unit=mg/kg body weight per day; context=maternal lowest-observed-effect level (LOEL) = 50 mg/kg body weight per day] Results across the few inhalation bioassays identified were fairly consistent. |
| WHO/JECFA | LOEL | =50 | mg/kg bw/day | - | inhalation | - | Inhalation toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=226b735be70340aa; raw_unit=mg/kg body weight per day; context=maternal lowest-observed-effect level (LOEL) = 50 mg/kg body weight per day] Results across the few inhalation bioassays identified were fairly consistent. |
| WHO/JECFA | NOAEL | =41 | mg/kg bw/day | - | oral | - | Reproductive toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2be86f020a8fd19f; raw_unit=mg/kg body weight per day; context=treatment) and then by gavage at 41 mg/kg body weight per day (in corn oil) through young adulthood; at this dose, there was hepatocellular degeneration in females (EHRT, 1988). [NOAEL for fertility = 41 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =126 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=64c4576b99dacc3c; raw_unit=mg/kg body weight per day; context=[NOAEL for developmental toxicity = 126 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =400 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=69b9733bf8791676; raw_unit=mg/kg body weight per day; context=[ NOAEL for developmental toxicity = 400 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =10 | mg/kg bw/day | Mouse | - | 3 weeks | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=5d331f1c883ccd7f; raw_unit=mg/kg body weight per day; context=The NOAEL for cytolethality and regenerative hyperplasia (in the liver) in mice was 10 mg/kg body weight per day after administration of chloroform in corn oil for 3 weeks (from Larson et al., 1994c). |
| WHO/JECFA | NOAEL | =0.01 | mg/kg bw | Mouse | - | - | Carcinogenicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=0cab5fdb1bb63c81; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Based on the mode of action evidence for chloroform carcinogenicity, a TDI of 10 ug/kg body weight was derived, using the NOAEL for cytotoxicity in mice and applying an uncertainty factor of 1000 (10 each for inter- and intraspecies variation and 10 for the short duration of the study) (IPCS, 2000b). |
| WHO/JECFA | NOAEL | =41 | mg/kg bw/day | - | oral | - | Reproductive toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2be86f020a8fd19f; raw_unit=mg/kg body weight per day; context=treatment) and then by gavage at 41 mg/kg body weight per day (in corn oil) through young adulthood; at this dose, there was hepatocellular degeneration in females (EHRT, 1988). [NOAEL for fertility = 41 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =126 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=64c4576b99dacc3c; raw_unit=mg/kg body weight per day; context=[NOAEL for developmental toxicity = 126 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =400 | mg/kg bw/day | - | - | - | Developmental toxicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=69b9733bf8791676; raw_unit=mg/kg body weight per day; context=[ NOAEL for developmental toxicity = 400 mg/kg body weight per day; |
| WHO/JECFA | NOAEL | =10 | mg/kg bw/day | Mouse | - | 3 weeks | Toxicology study | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=5d331f1c883ccd7f; raw_unit=mg/kg body weight per day; context=The NOAEL for cytolethality and regenerative hyperplasia (in the liver) in mice was 10 mg/kg body weight per day after administration of chloroform in corn oil for 3 weeks (from Larson et al., 1994c). |
| WHO/JECFA | NOAEL | =0.01 | mg/kg bw | Mouse | - | - | Carcinogenicity | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=0cab5fdb1bb63c81; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Based on the mode of action evidence for chloroform carcinogenicity, a TDI of 10 ug/kg body weight was derived, using the NOAEL for cytotoxicity in mice and applying an uncertainty factor of 1000 (10 each for inter- and intraspecies variation and 10 for the short duration of the study) (IPCS, 2000b). |
| WHO/JECFA | TDI | =0.01 | mg/kg bw/day | Mouse | - | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=29fb98324e43c441; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Based on the mode of action evidence for chloroform carcinogenicity, a TDI of 10 ug/kg body weight was derived, using the NOAEL for cytotoxicity in mice and applying an uncertainty factor of 1000 (10 each for inter- and intraspecies variation and 10 for the short duration of the study) (IPCS, 2000b). |
| WHO/JECFA | TDI | =0.013 | mg/kg bw/day | Dog | oral | 7.5 years | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=fd0d78995db26264; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Previously, a WHO Task Group on drinking-water quality guidelines had derived a TDI of 13 ug/kg body weight, by applying an uncertainty factor of 1000 to the LOAEL of 15 mg/kg body weight per day seen in dogs given chloroform for 7.5 years. |
| WHO/JECFA | TDI | =0.2 | mg/L | Human | oral | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2705d28d045ee887; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=Allocation of 50% of this TDI to drinking-water resulted in a guideline value for chloroform of 200 ug/litre drinking-water, assuming a person weighs 60 kg and ingests 2 litres of water per day. |
| WHO/JECFA | TDI | =0.015 | mg/kg bw/day | Dog | inhalation | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2b887775e731679c; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=13 In a report on air quality guidelines, WHO tabulated a TDI for chloroform of 15 ug/kg body weight per day for non-carcinogenic end-points, based on the 1979 dog study. |
| WHO/JECFA | TDI | =0.01 | mg/kg bw/day | Mouse | - | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=29fb98324e43c441; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Based on the mode of action evidence for chloroform carcinogenicity, a TDI of 10 ug/kg body weight was derived, using the NOAEL for cytotoxicity in mice and applying an uncertainty factor of 1000 (10 each for inter- and intraspecies variation and 10 for the short duration of the study) (IPCS, 2000b). |
| WHO/JECFA | TDI | =0.013 | mg/kg bw/day | Dog | oral | 7.5 years | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=fd0d78995db26264; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=Previously, a WHO Task Group on drinking-water quality guidelines had derived a TDI of 13 ug/kg body weight, by applying an uncertainty factor of 1000 to the LOAEL of 15 mg/kg body weight per day seen in dogs given chloroform for 7.5 years. |
| WHO/JECFA | TDI | =0.2 | mg/L | Human | oral | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2705d28d045ee887; raw_unit=ug/litre; unit_normalization=converted from micrograms; context=Allocation of 50% of this TDI to drinking-water resulted in a guideline value for chloroform of 200 ug/litre drinking-water, assuming a person weighs 60 kg and ingests 2 litres of water per day. |
| WHO/JECFA | TDI | =0.015 | mg/kg bw/day | Dog | inhalation | - | Health guidance value | document_id=cicads_cicads_cicad58; title=Chloroform (Cicads 58, 2004); path=mirror/documents/cicads/cicads/cicad58.htm; row_hash=2b887775e731679c; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=13 In a report on air quality guidelines, WHO tabulated a TDI for chloroform of 15 ug/kg body weight per day for non-carcinogenic end-points, based on the 1979 dog study. |
| WHO/JECFA | NOEL | =10 | mg/kg bw/day | Mouse | - | 3 weeks | Carcinogenicity | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=a7e15994fc142073; raw_unit=mg/kg body weight per day; context=Based on the NOEL for cytolethality and cell proliferation in B6C3F 1 mice of 10 mg/kg body weight per day, following administration in corn oil for 3 weeks in the study of Larson et al. (1994a) and incorporating an uncertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for severity of effect, i.e. carcinogenicity, and l |
| WHO/JECFA | NOEL | =14.7 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=fdf97e7583ea5685; raw_unit=mg/m 3; context=The NOEL for these effects was 14.7 mg/m 3 (3 ppm). |
| WHO/JECFA | NOEL | =10 | mg/kg bw/day | Mouse | - | 3 weeks | Carcinogenicity | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=a7e15994fc142073; raw_unit=mg/kg body weight per day; context=Based on the NOEL for cytolethality and cell proliferation in B6C3F 1 mice of 10 mg/kg body weight per day, following administration in corn oil for 3 weeks in the study of Larson et al. (1994a) and incorporating an uncertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for severity of effect, i.e. carcinogenicity, and l |
| WHO/JECFA | NOEL | =14.7 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=fdf97e7583ea5685; raw_unit=mg/m 3; context=The NOEL for these effects was 14.7 mg/m 3 (3 ppm). |
| WHO/JECFA | TDI | =0.015 | mg/kg bw/day | - | - | subchronic | Health guidance value | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=d44537b12ea2215a; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=ertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for use of an effect level rather than a no-effect level and a subchronic study), a TDI of 15 ug/kg body weight per day is obtained. |
| WHO/JECFA | TDI | =0.01 | mg/kg bw/day | - | - | chronic | Health guidance value | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=1176ebc6cfe37d40; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=an uncertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for severity of effect, i.e. carcinogenicity, and less-than-chronic study), a TDI of 10 ug/kg body weight per day is obtained. |
| WHO/JECFA | TDI | =0.015 | mg/kg bw/day | - | - | subchronic | Health guidance value | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=d44537b12ea2215a; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=ertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for use of an effect level rather than a no-effect level and a subchronic study), a TDI of 15 ug/kg body weight per day is obtained. |
| WHO/JECFA | TDI | =0.01 | mg/kg bw/day | - | - | chronic | Health guidance value | document_id=ehc_ehc_ehc163; title=Chloroform (EHC 163, 1994); path=mirror/documents/ehc/ehc/ehc163.htm; row_hash=1176ebc6cfe37d40; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=an uncertainty factor of 1000 (x10 for interspecies variation, x10 for intraspecies variation and x10 for severity of effect, i.e. carcinogenicity, and less-than-chronic study), a TDI of 10 ug/kg body weight per day is obtained. |
| WHO/JECFA | TDI | =0.0082 | mg/kg bw/day | Human; Rat | - | lifetime | Health guidance value | document_id=hsg_hsg_hsg87_e; title=Chloroform (HSG 87, 1994); path=mirror/documents/hsg/hsg/hsg87_e.htm; row_hash=fa16fa96fd776119; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The daily human uptake of chloroform (estimated to be 2 ug/kg body weight) is less than the lowest calculated TDI of 8.2 ug/kg body weight as a 10 -5 excess lifetime risk, based on the induction of renal tumours in male rats (see section 2). |
| WHO/JECFA | TDI | =0.0082 | mg/kg bw/day | Human; Rat | - | lifetime | Health guidance value | document_id=hsg_hsg_hsg87_e; title=Chloroform (HSG 87, 1994); path=mirror/documents/hsg/hsg/hsg87_e.htm; row_hash=fa16fa96fd776119; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The daily human uptake of chloroform (estimated to be 2 ug/kg body weight) is less than the lowest calculated TDI of 8.2 ug/kg body weight as a 10 -5 excess lifetime risk, based on the induction of renal tumours in male rats (see section 2). |
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 47.702 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=744; Record_ID=acute_inhalation_2773; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=47.702; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE acute inhalation | LC50 | 6 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=745; Record_ID=acute_inhalation_1848; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=6; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE acute inhalation | LC50 | 47.7183 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=746; Record_ID=acute_inhalation_1804; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=47.7183; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
NTP ICE acute oral 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1348 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9205; row=2019; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1117 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9204; row=2020; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =908 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_9203; row=2021; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =695 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_9202; row=2022; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >444 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_9200; row=2023; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2180 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10237; row=2024; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10234; row=2025; data_type=In Vivo; mixture=Chemical; chemical_name=Chloroform; preferred_name=Chloroform; dtxsid=DTXSID1020306; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020306; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 46.47 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=416; Record_ID=adme_parameters_1188; Data_Type=Measured; DTXSID=DTXSID1020306; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=46.47; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE adme parameters | Clint | 251.9 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=418; Record_ID=adme_parameters_1188; Data_Type=Measured; DTXSID=DTXSID1020306; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=251.9; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE adme parameters | Fu | 0.5672 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=417; Record_ID=adme_parameters_1188; Data_Type=Measured; DTXSID=DTXSID1020306; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.5672; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE adme parameters | Fu | 0.1762 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=419; Record_ID=adme_parameters_1188; Data_Type=Measured; DTXSID=DTXSID1020306; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.1762; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
NTP ICE cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1161; Record_ID=cancer_3202; Data_Type=WOE; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE cancer | Inhalation risk unit | 0.000023 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=1165; Record_ID=cancer_3204; Data_Type=WOE; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=2.3E-5; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0025_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE cancer | Top dose | 14 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1155; Record_ID=cancer_3201; Data_Type=In Vivo; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=14; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-000; URL=https://ntp.niehs.nih.gov/publications/reports/tr/trchloroform/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE cancer | Top dose | 250 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1157; Record_ID=cancer_3199; Data_Type=In Vivo; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=mg/kg/day; Species=Rat; Strain=Osborne Mendel; Sex=Female; Route=Gavage; Reference=TR-000; URL=https://ntp.niehs.nih.gov/publications/reports/tr/trchloroform/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE cancer | Top dose | 8 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1159; Record_ID=cancer_3200; Data_Type=In Vivo; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=8; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-000; URL=https://ntp.niehs.nih.gov/publications/reports/tr/trchloroform/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
| NTP ICE cancer | Top dose | 180 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1168; Record_ID=cancer_3206; Data_Type=In Vivo; Formulation_Name=Chloroform; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=180; Response_Unit=mg/kg/day; Species=Rat; Strain=Osborne Mendel; Sex=Male; Route=Gavage; Reference=TR-000; URL=https://ntp.niehs.nih.gov/publications/reports/tr/trchloroform/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=422; Record_ID=eye_irritation_121; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1020306; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020306; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020306 |
ToxValDB ATSDR MRLs 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =68.3513 | mg/m3 | Human | inhalation | chronic; 6 months | occupational | LONG_REF=Phoon WH, Goh KT, Lee LT, et al. 1983. Toxic jaundice from occupational exposure to chloroform. Med J Malaysia 38:31-34; TITLE=Toxic jaundice from occupational exposure to chloroform; AUTHOR=Phoon WH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp6.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447435:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_83f05005daf5d3048095a5c2f037b0ea |
| ToxValDB ATSDR MRLs | LOAEL | =9.76447 | mg/m3 | Human | inhalation | chronic; 4 years | occupational | LONG_REF=Bomski H, Sobolewska A, Strakowski A. 1967. [Toxic damage of the liver by chloroform in chemical industry workers.] Int Arch F Gewerbepathologie u. Gewerbehygiene 24: 127- 134 (German); TITLE=[Toxic damage of the liver by chloroform in chemical industry workers.]; AUTHOR=Bomski H; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp6.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447436:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9747d0de038f285d2583d7f2690b647c |
| ToxValDB ATSDR MRLs | MRL | =0.00488223 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5617339dfd03e56289ac6f53ab1edb4d |
| ToxValDB ATSDR MRLs | MRL | =0.00390579 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7fca47a3051c55b4dd874592a6287173 |
| ToxValDB ATSDR MRLs | MRL | =0.00195289 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d4c9698118ef877ff923dfbaabba347 |
| ToxValDB ATSDR MRLs | MRL | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in female mice; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d7aa6d981dc0892cb6c95e3186d9921 |
| ToxValDB ATSDR MRLs | MRL | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in male/female dogs; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a1857a4d008dbc946d1762f6448cf2c |
| ToxValDB ATSDR MRLs | MRL | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in male/female dogs; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e06408d5cadd49c0464b7a12ad4c36d4 |
| ToxValDB ATSDR MRLs | MRL | =0.00488223 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5617339dfd03e56289ac6f53ab1edb4d |
| ToxValDB ATSDR MRLs | MRL | =0.00390579 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7fca47a3051c55b4dd874592a6287173 |
| ToxValDB ATSDR MRLs | MRL | =0.00195289 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446934_15446935_15446936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d4c9698118ef877ff923dfbaabba347 |
| ToxValDB ATSDR MRLs | MRL | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in female mice; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d7aa6d981dc0892cb6c95e3186d9921 |
| ToxValDB ATSDR MRLs | MRL | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in male/female dogs; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a1857a4d008dbc946d1762f6448cf2c |
| ToxValDB ATSDR MRLs | MRL | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2024; ORIGINAL_YEAR=2024; TOXICOLOGICAL_EFFECT=hepatic in male/female dogs; STUDY_GROUP=ATSDR MRLs_dup_-_15446937_15446938_15446939:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e06408d5cadd49c0464b7a12ad4c36d4 |
| ToxValDB ATSDR MRLs | NOAEL | =26 | mg/kg bw/day | Mouse | oral | short-term; 4 days | short-term | LONG_REF=Larson JL, Wolf DC, Butterworth BE. 1994b. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3Ft mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water. Fund Appl Toxicol 22:90-102; TITLE=Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3Ft mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water; AUTHOR=Larson JL; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp6.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447437:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_503ece377527d16953e4d5385ae09501 |
| ToxValDB ATSDR MRLs | NOAEL | =15 | mg/kg bw/day | Dog | oral | chronic; 7.5 years | chronic | LONG_REF=Heywood R, Sortwell RJ, Noel PRB, et al. 1979. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.; TITLE=Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs; AUTHOR=Heywood R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp6.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447438_15447439:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6744791af3e91bc8ddda9d4c3d38ad0f |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =14.6467 | mg/m3 | Mouse | inhalation | short-term; 7 days | short-term | LONG_REF=Larson JL, Wolf DC, Morgan KT, et al. 1994c. The toxicity of l-week exposures to inhaled chloroform in female B6C3F1 mice and male F-344 rats. Fund Appl Toxicol 22:431-446.; TITLE=The toxicity of l-week exposures to inhaled chloroform in female B6C3F1 mice and male F-344 rats; AUTHOR=Larson JL; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp6.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447433:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_00b66415b058b00b9b5ac1ad202ede6f |
ToxValDB Alaska DEC 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.002 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446030:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=8cfaeb9f5ba9b676523c129eaee0d7b2 |
| ToxValDB Alaska DEC | RfD | =0.01 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446032:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=cb4176869e716f0ca7ba4e615d02e218 |
| ToxValDB Alaska DEC | RfD | =0.002 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446030:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=8cfaeb9f5ba9b676523c129eaee0d7b2 |
| ToxValDB Alaska DEC | RfD | =0.01 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15446032:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=cb4176869e716f0ca7ba4e615d02e218 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | LOAEL | =146.467 | mg/m3 | Rat | inhalation | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Schwetz B, Leong B, Gehring P. Embryo- and fetotoxicity of inhaled chloroform in rats. Toxicol Appl Pharmacol 1974;28:442-451; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=fetotoxicity; STUDY_GROUP=Cal OEHHA REL derivations:15951917:F:-pregnant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c45b58ca1452089b1a57247f6c4e93b |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =122.056 | mg/m3 | Rat | inhalation | chronic; 6 months | chronic | LONG_REF=Torkelson T, Oyen F, and Rowe V. 1976. The toxicity of chloroform as determined by single and repeated exposure of laboratory animals. Am. Ind. Hyg. Assoc. J. 37:697-705; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Pathological changes in liver (degenerative), and kidneys (cloudy swelling); STUDY_GROUP=Cal OEHHA REL derivations:15952025:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b414ccf6cc4b44b0d38059960fa52d77 |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =41 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511585_15511586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_623b9373f8db6f4f93eb12492b721c14 |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =15 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511585_15511586:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e72ca5946c8f9392546c5bba459a9c0e |
ToxValDB ECOTOX 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1000 | mg/kg bw/day | Rat | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602854_15602855:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f9852c5435fe3c1e216925902463c610 |
| ToxValDB ECOTOX | NOEL | =500 | mg/kg bw/day | Rat | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602854_15602855:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cea0b4aa4fd9e6131d816e0c4935af16 |
| ToxValDB ECOTOX | NOEL | =5.7 | mmol/kg | Rat | oral | acute; 0.0556 days | acute | LONG_REF=Arch. Toxicol.61(1): 79-82 Hoffmann,P. Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats 1987; TITLE=Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats; AUTHOR=Hoffmann,P.; DOI=10.1007/BF00324553; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97720; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604102_15604103:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cdc30c9f98f25886f3e979b3e026de90 |
| ToxValDB ECOTOX | NOEL | =250 | mg/kg bw/day | Rat | oral | short-term; 1.625 days | short-term | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605867_15605868:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fa6d2572db9f29847adfc21df6734f54 |
| ToxValDB ECOTOX | NOEL | =1 | mL/kg bw | Rat | oral | acute; 1 days | acute | LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15608468:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a09df9caf05d5416341058c3c98551dd |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =122.056 | mg/m3 | Rabbit | inhalation | chronic; 6 months | chronic | LONG_REF=Torkelson, T.R., Oyen, F. and Rowe, V.K. (1976). The toxicity of chloroform as determined by single and repeated exposure of laboratory animals. J. Am. Ind. Hyg. Assoc. 37 , 697-705.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d3987; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/028_chloroform_oel_en.pdf; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=liver and kidney damage; STUDY_GROUP=EU SCOEL:15952360:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b971355f03a8960ee5dc6dbfc273f1af |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =2.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630664_15630665:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_94af9a61e9309b1fe5bcdf303873b3d5 |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | BMDL (10 ADJ) | =1 | mg/kg bw/day | Dog | oral | chronic; 7.5 years | chronic | LONG_REF=Heywood, R; Sortwell, RJ; Noel, PRB; et al. (1979) Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.; TITLE=Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs; AUTHOR=Heywood, R; Sortwell, RJ; Noel, PRB; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=25; TOXICOLOGICAL_EFFECT=fatty cyst formation in the liver and increased sgpt; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15644846_15644847_15644849_15644851:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6dfc86e167ee3abb7e73a68f1e4c1c8a |
| ToxValDB IRIS | BMDL (10) | =1.2 | mg/kg bw/day | Dog | oral | chronic; 7.5 years | chronic | LONG_REF=Heywood, R; Sortwell, RJ; Noel, PRB; et al. (1979) Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.; TITLE=Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs; AUTHOR=Heywood, R; Sortwell, RJ; Noel, PRB; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=25; TOXICOLOGICAL_EFFECT=fatty cyst formation in the liver and increased sgpt; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15644846_15644847_15644849_15644851:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af6b8e6405430e2a738fed35626a011b |
| ToxValDB IRIS | LOAEL (ADJ) | =12.9 | mg/kg bw/day | Dog | oral | chronic; 7.5 years | chronic | LONG_REF=Heywood, R; Sortwell, RJ; Noel, PRB; et al. (1979) Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs. J Environ Pathol Toxicol 2:835-851.; TITLE=Safety evaluation of toothpaste containing chloroform: III. Long-term study in beagle dogs; AUTHOR=Heywood, R; Sortwell, RJ; Noel, PRB; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4cd2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=25; TOXICOLOGICAL_EFFECT=fatty cyst formation in the liver and increased sgpt; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15644846_15644847_15644849_15644851:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d46c391c3ef36cca348697e9fe518651 |
ToxValDB NIOSH IDLH 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LEL | =5028.7 | mg/m3 | Human | inhalation | acute; 7 minutes | occupational | LONG_REF=Lehmann KB, Schmidt-Kehl L, Ruf H, Crescitelli, Dahl, Eppinghausen, Eshe, Falker, Grotefendt, Junkenita, Maier, Mergner, Pantehtsch, Schlitzer, Shoenes, Spettmann, Wirges, Bamsreiter, Benninger, Lazarus, Manasse, Kummeth, Reuss, Schwarzweller [1936]. The 13 most important chlorinated hydrocarbons of the aliphatic series from the standpoint of occupational hygiene. Arch Hyg Bakteriol 116:132-200 (translated).; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b377e4b02565fc7d6e3a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/67663.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=dizziness, intracranial pressure, and nausea; STUDY_GROUP=NIOSH IDLH:15953113:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dfa72b91bd584758aae61de0364337a4 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfC | =0.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649930:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56b9fd3a9a41143ffe01bf52b0b362da |
ToxValDB RSL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.098 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15655103_15663275_15663277:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7772c1a707b66db69ab933b09e8ad362 |
| ToxValDB RSL | RfC | =0.0976524 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15655103_15663275_15663277:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e40e04e61380f3a87a32336c9f9fbe95 |
| ToxValDB RSL | RfC | =0.244131 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_ATSDR_15655103_15663275_15663277:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3815f732eda2b9056968b967fcf12e37 |