Cholecalciferol PEG-12 Ether

INCI: CHOLECALCIFEROL PEG-12 ETHER

CAS Number
Not readily available (PEGylated vitamin D₃ derivative)
Function
Skin conditioning agent (vitamin D₃ derivative with enhanced solubility)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes No specific FDA restriction; no CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Potential 1,4-dioxane contamination from PEG ethoxylation process; cholecalciferol is biologically active (vitamin D₃) with possible systemic effects if absorption is significant; no dedicated safety assessment published

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Concern Level: Moderate

Regulatory Flags

peg-ingredient

Frequently Asked Questions

Is Cholecalciferol PEG-12 Ether safe in cosmetics?

Potential 1,4-dioxane contamination from PEG ethoxylation process; cholecalciferol is biologically active (vitamin D₃) with possible systemic effects if absorption is significant; no dedicated safety assessment published The EU classifies Cholecalciferol PEG-12 Ether as "restricted". Safety rating: MODERATE.

Is Cholecalciferol PEG-12 Ether allowed in the EU?

Cholecalciferol PEG-12 Ether EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cholecalciferol PEG-12 Ether do in cosmetics?

Cholecalciferol PEG-12 Ether functions as: Skin conditioning agent (vitamin D₃ derivative with enhanced solubility). It is classified as a cosmetic ingredient in our database. CAS number: Not readily available (PEGylated vitamin D₃ derivative).

What is the Margin of Safety for Cholecalciferol PEG-12 Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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