NOAEL Studies Cosmetic Ingredient

CI 10316 (Ext. D&C Yellow No. 7) NOAEL Studies

INCI: CI 10316

CAS: 846-70-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 30 mg/kg bw/day rat oral 90 day Subchronic PAFA; Damme, B.et al. 13-Week Oral (Gavage) ToxicityStudy in the Wistar Rat; RCC
SCCNFP Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =0 mg/kg bw/day guinea pig - 18 month developmental toxicity Ref.: 12 Human studies No data 2, p.16
SCCNFP Opinion NOAEL =30 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.8
SCCNFP Opinion NOAEL =50 mg/kg bw/day pig - developmental developmental toxicity p.12
SCCS Opinion 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0009 mg/kg bw rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =0.0011 mg/kg bw rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =30 mg/kg bw/day - - Chronic genotoxicity p.17
SCCS Opinion NOAEL =30 mg/kg bw rat oral 90-day dermal absorption p.23
SCCS Opinion NOAEL =50 mg/kg bw/day human - developmental developmental toxicity p.22
Regulatory source 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 0 mg/kg bw/day guinea pig - 18 month developmental toxicity p.16
Regulatory source developmental toxicity 50 mg/kg bw/day pig - developmental developmental toxicity p.12
Regulatory source developmental toxicity 50 mg/kg bw/day guinea pig - 18 month developmental toxicity p.16
Regulatory source repeated dose toxicity 30 mg/kg bw/day - dermal Sub-chronic repeated dose toxicity p.8
Regulatory source dermal absorption =0.0009 mg/kg bw rat oral 90-day dermal absorption p.23
Regulatory source dermal absorption =0.0011 mg/kg bw rat oral 90-day dermal absorption p.23
Regulatory source dermal absorption =30 mg/kg bw rat oral 90-day dermal absorption p.23
Regulatory source developmental toxicity 30 mg/kg bw/day human - 90-day developmental toxicity p.23
Regulatory source developmental toxicity 50 mg/kg bw/day human - developmental developmental toxicity p.22
Regulatory source developmental toxicity 50 mg/kg bw/day human - 90-day developmental toxicity p.23
Regulatory source genotoxicity 30 mg/kg bw/day - - Chronic genotoxicity p.17
openFDA substances 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 08F8S9O3I5 UNII - - - chemical -
openFDA substances FDA UNII substance identifier concept identifier - - - concept -