Is CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) safe in cosmetics?
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1)
Also known as: EC No.: 209-608-2, Benzenesulfonic acid, 3-[2-[4-(phenylamino)phenyl]diazenyl]-, sodium salt (1:1), Benzenesulfonic acid, 3-[[4-(phenylamino)phenyl]azo]-, monosodium salt, Benzenesulfonic acid, m-(p-anilinophenylazo)-, sodium salt, Sodium 4′-anilinoazobenzene-3-sulfonate (+15 more)
INCI: CI 13065
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) (CAS 587-98-4) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 587-98-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H318, H319, H332, H361f, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
InChIKey
NYGZLYXAPMMJTE-UHFFFAOYSA-M
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Delisted by FDA on December 13, 1977 (21 CFR 81.10, 81.30). Originally approved in 1939 as Ext. D&C Yellow No. 1 for external drugs and cosmetics; delisted due to contamination with 4-aminobiphenyl (a known human carcinogen) and inability to produce the dye without benzidine-related impurities. No longer permitted in any FDA-regulated cosmetic or drug product in the United States.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 387
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 387
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | banned | - | - |
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1).
Regulatory Flags
eu-not-in-annex-iv
not-fda-approved
fda-delisted-1977
4-aminobiphenyl-contamination
benzidine-precursor
neurotoxic
hepatotoxic
genotoxic
azo-dye
aromatic-amine-precursor
carcinogenic-impurities
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
EC No.: 209-608-2
Benzenesulfonic acid, 3-[2-[4-(phenylamino)phenyl]diazenyl]-, sodium salt (1:1)
Benzenesulfonic acid, 3-[[4-(phenylamino)phenyl]azo]-, monosodium salt
Benzenesulfonic acid, m-(p-anilinophenylazo)-, sodium salt
Sodium 4′-anilinoazobenzene-3-sulfonate
C.I. Acid Yellow 36
C.I. Acid Yellow 36 monosodium salt
11363 Yellow
Acid Leather Yellow R
Acid Leather Yellow PRW
Acid Metanil Yellow
Acid Yellow 36
Acidic Metanil Yellow
Aizen Metanil Yellow
Amacid Yellow M
Benzenesulfonic acid, m-((p-anilinophenyl)azo)-, sodium salt
Brasilan Metanil Yellow
Bucacid Metanil Yellow
Calcocid Yellow MXXX
Diacid Metanil Yellow
Chemical Function
Dye
Pigment
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
banned; Europe; Personal care
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) allowed in the EU?
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) do in cosmetics?
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 587-98-4.
Is CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) used outside cosmetics?
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) have different safety status in cosmetics vs industrial chemicals?
CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H317, H318, H319, H332, H361f, H411).
Compliance Tools
Check CI 13065 (Acid Yellow 36 / Metanil Yellow / Ext. D&C Yellow No. 1) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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