NOAEL Studies Cosmetic Ingredient

CI 14700 (FD&C Red No. 4 / Red 4) NOAEL Studies

INCI: CI 14700

CAS: 4548-53-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6570; row=3908; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Red 4; preferred_name=FD&C Red 4; dtxsid=DTXSID2021234; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021234; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021234; source_file=acute_oral.xlsx
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=2604; Record_ID=cancer_1629; Data_Type=WOE; Formulation_Name=FD&C Red 4; Mixture=Chemical; DTXSID=DTXSID2021234; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/26; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021234
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9324; RecordID=ARPathway2016_1217; DatasetName=ARPathway2016; DTXSID=DTXSID2021234; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021234; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021234
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =1.5 mg/kg bw/day Hamster dermal - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d93e4b096bca8776498; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17284/7/6/4?documentUUID=4ef657bb-2068-4ffe-ae1d-0d0d195e59c0; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826224_15826552:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f31ba9b8c5919440ca6521c3ef4a3810
ECHA NOAEL =1.5 mg/kg bw/day Rat dermal - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d82e4b096bca877604a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17284/7/6/4?documentUUID=4ef657bb-2068-4ffe-ae1d-0d0d195e59c0; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15826207:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8feedb8cda8d7140aad592e39842e1eb
ECHA NOAEL =1000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c7b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20429/7/8?documentUUID=803bb7a5-ccd1-4836-8c7e-ccffc716dd06; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID:15820442:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e31e2158435ec6885292c6cc24d028f3
ECHA NOAEL =1500 mg/kg bw/day Mouse dermal - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f7e4b0a7c65d21afc0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17284/7/9/2?documentUUID=4ef657bb-2068-4ffe-ae1d-0d0d195e59c0; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15857766:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5dd27a63d309ae8f080ccd3af7158f03
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X3W0AM1JLX UNII - - - chemical -