NOAEL Studies Cosmetic Ingredient

CI 17200 NOAEL Studies

CAS: 3567-66-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0 mg/kg bw rat oral developmental developmental toxicity p.21
SCCS Opinion NOAEL =0.18 mg/kg rat oral - dermal absorption p.21
SCCS Opinion NOAEL =25 mg/kg bw/d rat oral 100 d NOAEL study Ref.: 10 B, p.12
SCCS Opinion NOAEL =25 mg/kg rat oral - dermal absorption p.21
SCCS Opinion NOAEL =102 mg/kg bw/d rat oral 18 months NOAEL study Ref.: 9 C, p.13
SCCS Opinion NOAEL =102 mg/kg bw rat - developmental reproductive toxicity p.20
SCCS Opinion NOAEL =129 mg/kg bw rat - developmental reproductive toxicity p.20
ECHA 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =181 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c81; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820445:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f300af252beb39b6046bb09d61b69b7
ECHA LOAEL =750 mg/kg bw/day Dog oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c51; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15848931:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_abc17eef26af8031575d624da098a719
ECHA NOAEL =20 mg/kg bw/day Rabbit dermal short-term; 4 weeks short-term QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d4be4b096bca877542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/4?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15826131:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7cf09c45bf967f877ec4d4154867450c
ECHA NOAEL =25 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd960; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/9/3?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15821525:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e69f75d24a38f90a12f59d0a9acf21ed
ECHA NOAEL =100 mg/kg bw/day Rat oral subchronic; 6 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15849424:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5deaff2f37bc6b68cd56152b8e8f8b93
ECHA NOAEL =102 mg/kg bw/day Rat oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820444:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c1228f06568b39c2bda2371a3c9193cc
ECHA NOAEL =129 mg/kg bw/day Rat oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820443:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fa6d2c1051fe3f9eacca668107db976a
ECHA NOAEL =150 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c81; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820446:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d88c8627bea34457680d15e41309f21
ECHA NOAEL =1500 mg/kg bw/day Mouse dermal - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15817676:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edb5bdd08dfd1cf84dd9ab6746a851dd
ECHA NOAEL =2500 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15849420:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f4038a4dbb0083f5c92a3215b39e803d
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 25 mg/kg bw/d rat oral 100 d - p.12
Regulatory source - 102 mg/kg bw/d rat oral 18 months - p.13
Regulatory source dermal absorption =0.18 mg/kg rat oral - dermal absorption p.21
Regulatory source dermal absorption =25 mg/kg rat oral - dermal absorption p.21
Regulatory source developmental toxicity 0 mg/kg bw rat oral developmental developmental toxicity p.21
Regulatory source developmental toxicity 25 mg/kg bw/d rat oral developmental developmental toxicity p.21
Regulatory source developmental toxicity 129 mg/kg bw rat oral developmental developmental toxicity p.21
Regulatory source reproductive toxicity 102 mg/kg bw rat - developmental reproductive toxicity p.20
Regulatory source reproductive toxicity 129 mg/kg bw rat - developmental reproductive toxicity p.20
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9DBA0SBB0L UNII - - - chemical -