NOAEL Studies
Cosmetic Ingredient
CI 45350 NOAEL Studies
CAS: 518-47-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =6721 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_7045; row=15649; data_type=In Vivo; mixture=Chemical; chemical_name=Fluorescein sodium; preferred_name=Fluorescein sodium; dtxsid=DTXSID9025328; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025328; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9025328; source_file=acute_oral.xlsx |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =1500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bddbf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17278/7/9/3?documentUUID=430cf8b5-37e7-49c0-a764-288732cc7a1f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823481:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_71dd507cfcc50a6244630ca9154d0e76 |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb44e4b0a7c65d22581d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17278/7/6/2?documentUUID=430cf8b5-37e7-49c0-a764-288732cc7a1f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847315_15847733:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7b39a04dc73301cda047a3ef3503444a |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Rabbit | oral | short-term; 22 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb44e4b0a7c65d225802; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17278/7/6/2?documentUUID=430cf8b5-37e7-49c0-a764-288732cc7a1f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847398_15847763:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e4149ce69ff564eda9a2bb123ecf4d55 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2241.4 | mg/kg bw/day | Rabbit | injection | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c904e4b0a7c65d21b1e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17278/7/9/2?documentUUID=430cf8b5-37e7-49c0-a764-288732cc7a1f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857730_15857742:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d22ab81aa3c732018297858582fb6072 |
| ToxValDB_ECHA_IUCLID | NOEL | =250 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bddc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17278/7/9/3?documentUUID=430cf8b5-37e7-49c0-a764-288732cc7a1f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823854:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_344389b12dde31b5dac1cd796288078d |
openFDA substances 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 93X55PE38X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H10O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"93X55PE38X"} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | 93X55PE38X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H10O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"93X55PE38X"} |
| openFDA substances | FDA UNII substance identifier | 93X55PE38X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H10O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"93X55PE38X"} |
| openFDA substances | FDA UNII substance identifier | 93X55PE38X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H10O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"93X55PE38X"} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |