NOAEL Studies Cosmetic Ingredient

CI 77713 NOAEL Studies

CAS: 546-93-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =1.25 % rat oral 62-d developmental toxicity 331; 0; 5, p.23
CIR Safety Assessment NOAEL =290 mg/kg body weight/d - - - NOAEL study 290; 41; 1), p.13
CIR Safety Assessment NOAEL >331 mg/kg body weight/d rat oral - oral toxicity 800; 4; 6, p.13
CIR Safety Assessment NOAEL =414 mg/kg body weight/d rat oral 29 d developmental toxicity 3; 28; 29, p.10
CIR Safety Assessment NOAEL <684 mg/kg body weight/d rat inhalation - inhalation toxicity 3; 684; 30, p.11
CIR Safety Assessment NOAEL >800 mg/kg body weight/d rat oral - oral toxicity 800; 4; 6, p.13
CIR Safety Assessment NOAEL =1000 mg/kg body weight/d rat oral 14 d developmental toxicity 14; 3; 28, p.10
CIR Safety Assessment NOAEL =1963 mg/kg body weight mouse oral - developmental toxicity 1; 25; 22, p.13
CIR Safety Assessment NOAEL =4128 mg/kg body weight/d rat oral 14 d repeated dose toxicity 14; 3; 28, p.22
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7536; row=7947; data_type=In Vivo; mixture=Chemical; chemical_name=Magnesium carbonate (1:1); preferred_name=Magnesium carbonate (1:1); dtxsid=DTXSID4049660; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4049660; source_file=acute_oral.xlsx
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 290 mg/kg body weight/d - - - - p.13
Regulatory source developmental toxicity 1.25 % rat oral 62-d developmental toxicity p.23
Regulatory source developmental toxicity 414 mg/kg body weight/d rat oral 29 d developmental toxicity p.10
Regulatory source developmental toxicity 1000 mg/kg body weight/d rat oral 14 d developmental toxicity p.10
Regulatory source developmental toxicity 1963 mg/kg body weight mouse oral - developmental toxicity p.13
Regulatory source inhalation toxicity <684 mg/kg body weight/d rat inhalation - inhalation toxicity p.11
Regulatory source oral toxicity >331 mg/kg body weight/d rat oral - oral toxicity p.13
Regulatory source oral toxicity >800 mg/kg body weight/d rat oral - oral toxicity p.13
Regulatory source repeated dose toxicity 4128 mg/kg body weight/d rat oral 14 d repeated dose toxicity p.22
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0IHC698356 UNII - - - chemical -