NOAEL Studies
Active Ingredient
Silver NOAEL Studies
INCI: SILVER
CAS: 7440-22-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 33 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 125 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=a40de15f-6f75-45d8-b8c0-f89ca0a80d08_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=a40de15f-6f75-45d8-b8c0-f89ca0a80d08/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=bda221be-e3dd-4a61-ab42-529f771fa24a |
| ECHA | LOAEL | <=40 | mg/kg bw/day | - | - | - | extended one-generation reproductive toxicity - with both developmental neuro- and immunotoxicity (Cohorts 1A, 1B without extension, 2A, 2B, and 3) | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=811bf8a2-190e-4265-834a-a7ca4986af5d_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=811bf8a2-190e-4265-834a-a7ca4986af5d/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; basis=gross pathology; key_result=true; upper_value=40; entry_uuid=13113a09-7ca3-4629-8a51-f72c9fceff4e |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=7c5d12d0-6075-40ce-8f96-2452ee7506e6_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=7c5d12d0-6075-40ce-8f96-2452ee7506e6/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2013; basis=other:; key_result=false; entry_uuid=a63ec62d-b7ca-4333-a133-38834a3d7b39 |
| ECHA | LOAEL | 30 | mg/kg bw/day | - | - | - | developmental toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=aebdb00a-784e-4199-9d5c-031056926532_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=aebdb00a-784e-4199-9d5c-031056926532/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=5702541b-6b4d-4782-9447-1d1f3c845a4a |
| ECHA | LOAEL | 4 | mg/kg bw/day | rat | oral: drinking water | - | developmental immunotoxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=53fbd963-9ec0-4add-a06b-a32c648f64d1_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=53fbd963-9ec0-4add-a06b-a32c648f64d1/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2016; basis=developmental immunotoxicity; key_result=false; entry_uuid=5a6b167e-a2ba-464b-820d-e6a8d54270b4 |
| ECHA | NOAEL | 30 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=a40de15f-6f75-45d8-b8c0-f89ca0a80d08_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=a40de15f-6f75-45d8-b8c0-f89ca0a80d08/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=48984d7e-f823-49ce-b3a3-4bf6f85a8a06 |
| ECHA | NOAEL | >=120 | mg/kg bw/day | - | - | - | extended one-generation reproductive toxicity - with both developmental neuro- and immunotoxicity (Cohorts 1A, 1B without extension, 2A, 2B, and 3) | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=811bf8a2-190e-4265-834a-a7ca4986af5d_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=811bf8a2-190e-4265-834a-a7ca4986af5d/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; basis=reproductive performance; key_result=true; entry_uuid=6043cd3d-2fcc-42b6-b4d3-315fe0559ae8 |
| ECHA | NOAEL | <=80 | mg/kg bw/day | - | - | - | extended one-generation reproductive toxicity - with both developmental neuro- and immunotoxicity (Cohorts 1A, 1B without extension, 2A, 2B, and 3) | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=811bf8a2-190e-4265-834a-a7ca4986af5d_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=811bf8a2-190e-4265-834a-a7ca4986af5d/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; basis=mortality; key_result=true; upper_value=80; entry_uuid=e5b3373d-d7f8-4aa7-a645-ae12e77c29b1 |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=7c5d12d0-6075-40ce-8f96-2452ee7506e6_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=7c5d12d0-6075-40ce-8f96-2452ee7506e6/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2013; basis=other:; key_result=false; entry_uuid=51a310cc-e715-4f1e-a08c-3e180939a2a7 |
| ECHA | NOAEL | 40 | mg/kg bw/day | - | - | - | one-generation reproductive toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=2793e30e-cc45-4336-95e9-ba6e2aa43c5a_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=2793e30e-cc45-4336-95e9-ba6e2aa43c5a/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; basis=viability; key_result=true; entry_uuid=b67c323e-e6c0-4247-be61-787cb2b14789 |
| ECHA | NOAEL | 36 | mg/kg bw/day | rat | oral: gavage | - | reproductive toxicity, other | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=45224929-0964-4198-9bb3-6a56c73607a3_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=45224929-0964-4198-9bb3-6a56c73607a3/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-01-05; basis=reproductive function (oestrous cycle); key_result=false; entry_uuid=672e4573-a523-4809-aea4-e59ed6d7b6ab |
| ECHA | NOAEL | 10 | mg/kg bw/day | - | - | - | developmental toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=aebdb00a-784e-4199-9d5c-031056926532_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=aebdb00a-784e-4199-9d5c-031056926532/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=75b5ad3b-0ba6-441c-8a8b-1e01c04a8ed1 |
| ECHA | NOAEL | >100 | mg/kg bw/day | - | - | - | developmental toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=aebdb00a-784e-4199-9d5c-031056926532_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=aebdb00a-784e-4199-9d5c-031056926532/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=ba234397-95ac-40c9-98ee-8537d725f3a4 |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=74cd7dec-5947-469b-b89a-399a41103b2c_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=74cd7dec-5947-469b-b89a-399a41103b2c/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2013; basis=behaviour (functional findings); key_result=false; entry_uuid=9fc5b01b-3ad9-4c97-95b3-221fc2dd6b02 |
| ECHA | NOAEL | 515.3 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=41423335-e331-428d-9c14-508ea04c6705_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=41423335-e331-428d-9c14-508ea04c6705/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; basis=other:; key_result=false; entry_uuid=63f0531c-9456-4b77-805c-9303e34e2475 |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=527a3468-ba4c-43d0-aedd-78a2dae66ca9_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=527a3468-ba4c-43d0-aedd-78a2dae66ca9/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=false; entry_uuid=37a4d648-2dc3-4a16-8f98-d621eb45b97e |
| ECHA | NOAEL | 0.4 | mg/kg bw/day | rat | oral: drinking water | - | developmental immunotoxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=53fbd963-9ec0-4add-a06b-a32c648f64d1_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=53fbd963-9ec0-4add-a06b-a32c648f64d1/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2016; basis=developmental immunotoxicity; key_result=false; entry_uuid=0f16d377-f882-428a-91a4-56d4a56dd914 |
| ECHA | NOAEL | 400 | mg/kg bw/day | rat | oral: gavage | - | reproductive toxicity, other | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=ab5a4c13-e2ff-4345-8065-b3400132d1bc_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=ab5a4c13-e2ff-4345-8065-b3400132d1bc/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-01-05; basis=reproductive function (oestrous cycle); key_result=true; entry_uuid=672e4573-a523-4809-aea4-e59ed6d7b6ab |
| ECHA | NOAEL | 4 | mg/kg bw/day | rat | oral: drinking water | - | one-generation reproductive toxicity | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=5ce70463-4834-4f3e-bf7a-e5ee571a6c07_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=5ce70463-4834-4f3e-bf7a-e5ee571a6c07/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2017; basis=water consumption and compound intake; key_result=false; entry_uuid=7154c810-e2a6-4716-a56d-ae658d63ab2a |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | other: | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=a70ce4c1-768c-4e7c-a8ce-4f165144e43f_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=a70ce4c1-768c-4e7c-a8ce-4f165144e43f/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1998; basis=other:; key_result=false; entry_uuid=c3fa1e8c-92ed-4f82-bb57-d4455010eb49 |
| ECHA | NOAEL | >=320 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=a842c2ff-dd8f-473d-bb15-a27046511baa.i6z; document=b12e4eed-7842-46ca-bb6f-24539b65f881_a842c2ff-dd8f-473d-bb15-a27046511baa.i6d; document_key=b12e4eed-7842-46ca-bb6f-24539b65f881/a842c2ff-dd8f-473d-bb15-a27046511baa; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2022; ReportDate=2022-02-07; basis=body weight and weight gain; key_result=false; entry_uuid=e44000cd-bb6c-4b29-89ec-aa85473846d9 |
| ECHA | LOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacb3e4b0a7c65d1c0640; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11913/7/6/2?documentUUID=23950611-8c31-4047-bbd0-b9d313a1d2da; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837406_15839949_15846439_15850224_15850225_15850226:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ade1d8e758dcb5d37ae295befc708ca3 |
| ECHA | LOAEL | >=40 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb6bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/6/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=serum/plasma biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID:15849820:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3967796cb24d57bc237dfe8ae9379032 |
| ECHA | LOAEL | =4 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab59e4b0a7c65d1b9cb5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/9/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=F1: developmental immunotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15858559:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_795d3e5e6b4b73fcaf4c773930b998ba |
| ECHA | NOAEC | >=0.061 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/6/3?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827227:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69a80685b830ceac32b217d24accdd70 |
| ECHA | NOAEC | >=0.115 | mg/m3 | Rat | inhalation | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/6/3?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID:15827470:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b8cfd0ec42e3d99d61e0c36adb418f8a |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb6d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/6/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849821:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_162babb58875705a566458202ef95ee9 |
| ECHA | NOAEL | =30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae5ae4b0a7c65d1c8e11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5603/7/6/2?documentUUID=de2eca6c-217e-4af6-b0cb-50d9f7b88e62; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837406_15839949_15846439_15850224_15850225_15850226:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0c270400410ab9921458da1f0207c290 |
| ECHA | NOAEL | =36 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb6ea; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/6/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=clinical biochemistry|clinical signs|haematology|histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850909_15850988_15851026:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4aa6df0a67c9f75c3b7619eff4f2f2fb |
| ECHA | NOAEL | =250 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab59e4b0a7c65d1b9cbb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/9/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856209_15857684:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dfe25e61d8460bdb1e2fa7c5d424e68 |
| ECHA | NOAEL | =80 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c93ee4b0a7c65d21c232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/9/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=P0: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15857011:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7a41b63f09f4f46ee3d748589fa1bbe |
| ECHA | NOAEL | =0.4 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab59e4b0a7c65d1b9cb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/9/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=F1: viability|F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858310_15858752_15858785:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_246fe45d48c73813240e68b59c494f08 |
| ECHA | NOAEL | =4 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab59e4b0a7c65d1b9cb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/9/2?documentUUID=a842c2ff-dd8f-473d-bb15-a27046511baa; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=F1: test mat.|F1: mortality|F1: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|organ weight|other; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858310_15858752_15858785:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4c8b3de8a5a0b88381e389acd0b144ba |
Regulatory source 68 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =0.014 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=e7fe64cc0849a8c9; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 1.4e-2 mg/kg-day; system=Dermal; basis=Argyria; point_of_departure=LOAEL : 1.4e-2 mg/kg-day; composite_uf=3; confidence=Low; dtxsid=DTXSID4024305; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=99; rfd_last_updated=12/01/1991; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0099_summary.pdf |
| Regulatory source | RfD | =0.005 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=6ddb65163759785e; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-3; system=Dermal; basis=Argyria; point_of_departure=LOAEL : 1.4e-2 mg/kg-day; composite_uf=3; confidence=Low; dtxsid=DTXSID4024305; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=99; rfd_last_updated=12/01/1991; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0099_summary.pdf |
| Regulatory source | - | 0 | - | - | oral | 90-day | - | p.43 |
| Regulatory source | - | 0.00056 | mg/kg bw/d | human | oral | 70 years | - | p.21 |
| Regulatory source | - | 0.0045 | mg/kg bw/d | rat | oral | 12 months | - | p.30 |
| Regulatory source | - | 0.0045 | mg/kg bw/d | - | oral | - | - | p.31 |
| Regulatory source | - | 0.0065 | mg/kg bw/d | human | oral | 70 years | - | p.22 |
| Regulatory source | - | 0.05 | mg/kg | human | oral | - | - | p.29 |
| Regulatory source | - | 0.5 | % | rat | oral | 30-day | - | p.41 |
| Regulatory source | - | 1 | - | - | - | - | - | p.47 |
| Regulatory source | - | 9 | - | rat | oral | 28-day | - | p.41 |
| Regulatory source | - | 10 | - | human | oral | - | - | p.29 |
| Regulatory source | - | 13 | % | human | oral | 64 years | - | p.29 |
| Regulatory source | - | 30 | - | - | - | - | - | p.30 |
| Regulatory source | - | 40 | - | - | - | - | - | p.40 |
| Regulatory source | - | 41 | - | rat | oral | 90-day | - | p.41 |
| Regulatory source | - | 43 | - | - | oral | 90-day | - | p.43 |
| Regulatory source | - | 45 | - | - | oral | - | - | p.45 |
| Regulatory source | - | 70 | - | human | oral | 500 days | - | p.29 |
| Regulatory source | - | 78 | - | rat | oral | 90-day | - | p.41 |
| Regulatory source | - | 200 | mg/kg bw/day | rat | oral | 90-day | - | p.40 |
| Regulatory source | - | 250 | mg/kg | dog | oral | 90-day | - | p.43 |
| Regulatory source | - | 250 | mg/kg bw/day | dog | oral | 90-day | - | p.43 |
| Regulatory source | - | 500 | mg/kg bw/day | rat | oral | 90-day | - | p.40 |
| Regulatory source | - | 1000 | mg/kg | rat | oral | 90-day | - | p.43 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 28-day | - | p.40 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 90-day | - | p.43 |
| Regulatory source | - | 12500 | ppm | rat | oral | 14-week | - | p.42 |
| Regulatory source | - | 25500 | - | human | oral | 500 days | - | p.29 |
| Regulatory source | carcinogenicity | 0.2 | % | rat | oral | chronic | carcinogenicity | p.34 |
| Regulatory source | developmental toxicity | 10 | % | rat | oral | Prenatal | developmental toxicity | p.50 |
| Regulatory source | developmental toxicity | 13 | % | rat | oral | Prenatal | developmental toxicity | p.50 |
| Regulatory source | developmental toxicity | 20 | mg/kg bw/day | rat | - | Prenatal | developmental toxicity | p.49 |
| Regulatory source | developmental toxicity | 20 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.49 |
| Regulatory source | developmental toxicity | 20 | - | rat | - | Prenatal | developmental toxicity | p.49 |
| Regulatory source | developmental toxicity | 25 | % | rat | oral | Prenatal | developmental toxicity | p.50 |
| Regulatory source | developmental toxicity | 64.6 | % | rat | oral | Prenatal | developmental toxicity | p.49 |
| Regulatory source | developmental toxicity | 87 | mg/kg bw/day | - | - | developmental | developmental toxicity | p.48 |
| Regulatory source | developmental toxicity | 250 | mg/kg bw/day | rat | - | Prenatal | developmental toxicity | p.49 |
| Regulatory source | developmental toxicity | 1000 | mg/kg | rat | oral | developmental | developmental toxicity | p.50 |
| Regulatory source | repeated dose toxicity | 0.0045 | mg/kg bw/d | rat | oral | 9-year | repeated dose toxicity | p.25 |
| Regulatory source | repeated dose toxicity | 0.0045 | mg/kg bw/d | - | - | Developmental | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 0.0045 | mg/kg bw/d | rat | - | chronic | repeated dose toxicity | p.33 |
| Regulatory source | repeated dose toxicity | 0.0045 | mg/kg bw/d | rat | oral | chronic | repeated dose toxicity | p.33 |
| Regulatory source | repeated dose toxicity | 0.25 | mg/kg bw/d | - | - | developmental | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 0.25 | mg/kg bw/d | rat | oral | chronic | repeated dose toxicity | p.33 |
| Regulatory source | repeated dose toxicity | 0.5 | % | rat | oral | 30-day | repeated dose toxicity | p.41 |
| Regulatory source | repeated dose toxicity | 95 | - | rat | oral | Sub-chronic | repeated dose toxicity | p.41 |
| Regulatory source | repeated dose toxicity | 500 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.40 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.40 |
| Regulatory source | repeated dose toxicity | 1665 | - | rat | oral | Sub-acute | repeated dose toxicity | p.41 |
| Regulatory source | repeated dose toxicity | 12500 | ppm | rat | oral | 9 months | repeated dose toxicity | p.42 |
| Regulatory source | reproductive toxicity | 0 | - | - | - | developmental | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | 1 | - | - | - | developmental | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | 26 | - | - | - | developmental | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | 46 | - | - | - | - | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | 52 | - | rat | oral | 52 days | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 52 | - | - | - | developmental | reproductive toxicity | p.46 |
| Regulatory source | reproductive toxicity | 63.7 | % | rat | oral | 10 weeks | reproductive toxicity | p.47 |
| Regulatory source | reproductive toxicity | 100 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.15 |
| Regulatory source | reproductive toxicity | 250 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 250 | mg/kg bw/day | rat | - | developmental | reproductive toxicity | p.45 |
| Regulatory source | reproductive toxicity | 12500 | ppm | rat | oral | - | reproductive toxicity | p.48 |
| Regulatory source | reproductive toxicity | 20000 | ppm | rat | oral | 10 weeks | reproductive toxicity | p.47 |
| Regulatory source | reproductive toxicity | 20000 | ppm | rat | oral | - | reproductive toxicity | p.47 |
| Regulatory source | LOAEL | silver nitrate drinking-water study; 64% silver20 | mg Ag/kg | mouse | oral | 125 days | drinking water study | ICH Q3D(R2) Guideline for Elemental Impurities; Appendix 3; pde_route=oral; source_page=65; source_sha256=940176418af05c88ed33416a5d5e719a4ab7fe1d31cf1cd56ed331749b649c75; source_quote=PDE = 20 mg/kg x 50 kg / (12 x 10 x 5 x 1 x 10) = 167 ug/day A factor 10 was chosen for F5 because the LOAEL was used |
| Regulatory source | LOAEL | PDF says inadequate to set parenteral PDE1 | g metallic silver cumulative | human | parenteral | 2 to 9.75 years | intravenous case series | ICH Q3D(R2) Guideline for Elemental Impurities; Appendix 3; pde_route=parenteral; source_page=65; source_sha256=940176418af05c88ed33416a5d5e719a4ab7fe1d31cf1cd56ed331749b649c75; source_quote=the lowest cumulative dose of silver resulting in argyria was 1 g metallic silver. Argyria was reported in other patients at higher cumulative doses of silver. Using this study, the US EPA (2003) identified this dose as a LOAEL |
| Regulatory source | TLV | US DoL TLV0.01 | mg/m3 | - | inhalation | occupational | occupational exposure limit | ICH Q3D(R2) Guideline for Elemental Impurities; Appendix 3; pde_route=inhalation; source_page=66; source_sha256=940176418af05c88ed33416a5d5e719a4ab7fe1d31cf1cd56ed331749b649c75; source_quote=Using the Threshold Limit Value (TLV) of 0.01 mg/m3 for silver metal and soluble compounds |
ICH Q3D(R2) 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ICH Q3D(R2) | ICH Q3D PDE | 150 | ug/day | - | oral | - | ICH Q3D elemental impurity limit | - |
| ICH Q3D(R2) | ICH Q3D PDE | 15 | ug/day | - | parenteral | - | ICH Q3D elemental impurity limit | - |
| ICH Q3D(R2) | ICH Q3D PDE | 7 | ug/day | - | inhalation | - | ICH Q3D elemental impurity limit | - |
| ICH Q3D(R2) | ICH Q3D concentration limit | 15 | ug/g | - | oral concentration | - | ICH Q3D elemental impurity limit | - |
| ICH Q3D(R2) | ICH Q3D concentration limit | 1.5 | ug/g | - | parenteral concentration | - | ICH Q3D elemental impurity limit | - |
| ICH Q3D(R2) | ICH Q3D concentration limit | 0.7 | ug/g | - | inhalation concentration | - | ICH Q3D elemental impurity limit | - |
NTP ICE acute inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >5.16 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2403; Record_ID=acute_inhalation_681; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4024305; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.16; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/3/3/?documentUUID=09aba99a-f123-4c51-a470-12b999f56520; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024305; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024305 |
| NTP ICE acute inhalation | LC50 | >0.0008 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2404; Record_ID=acute_inhalation_682; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID4024305; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0008; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16155/7/3/3/?documentUUID=34c0b076-8c2e-4f59-91d4-fedbaa60dee5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4024305; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4024305 |
SCCS Opinion 43 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0 | - | - | oral | 90-day | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =0.00056 | mg/kg bw/d | human | oral | 70 years | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =0.0045 | mg/kg bw/d | rat | oral | 9-year | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =0.0045 | mg/kg bw/d | rat | oral | 12 months | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =0.0065 | mg/kg bw/d | human | oral | 70 years | NOAEL study | p.22 |
| SCCS Opinion | NOAEL | =0.05 | mg/kg | human | oral | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =0.2 | % | rat | oral | chronic | carcinogenicity | p.34 |
| SCCS Opinion | NOAEL | =0.25 | mg/kg bw/d | - | - | developmental | repeated dose toxicity | p.27 |
| SCCS Opinion | NOAEL | =0.25 | mg/kg bw/d | rat | oral | 12 months | repeated dose toxicity | p.25 |
| SCCS Opinion | NOAEL | =0.5 | % | rat | oral | 30-day | repeated dose toxicity | p.41 |
| SCCS Opinion | NOAEL | =1 | - | - | - | developmental | reproductive toxicity | p.46 |
| SCCS Opinion | NOAEL | =9 | - | rat | oral | 28-day | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =10 | - | human | oral | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =10 | % | rat | oral | Prenatal | developmental toxicity | p.50 |
| SCCS Opinion | NOAEL | =13 | % | human | oral | 64 years | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw/day | rat | - | Prenatal | developmental toxicity | p.49 |
| SCCS Opinion | NOAEL | =25 | % | rat | oral | Prenatal | developmental toxicity | p.50 |
| SCCS Opinion | NOAEL | =26 | - | - | - | developmental | reproductive toxicity | p.46 |
| SCCS Opinion | NOAEL | =30 | - | - | - | - | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =40 | - | - | - | - | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =41 | - | rat | oral | 90-day | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =43 | - | - | oral | 90-day | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =45 | - | - | oral | - | NOAEL study | p.45 |
| SCCS Opinion | NOAEL | =46 | - | - | - | - | reproductive toxicity | p.46 |
| SCCS Opinion | NOAEL | =52 | - | rat | oral | 52 days | reproductive toxicity | p.45 |
| SCCS Opinion | NOAEL | =63.7 | % | rat | oral | 10 weeks | reproductive toxicity | p.47 |
| SCCS Opinion | NOAEL | =64.6 | % | rat | oral | Prenatal | developmental toxicity | p.49 |
| SCCS Opinion | NOAEL | =70 | - | human | oral | 500 days | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =78 | - | rat | oral | 90-day | NOAEL study | p.41 |
| SCCS Opinion | NOAEL | =87 | mg/kg bw/day | - | - | developmental | developmental toxicity | p.48 |
| SCCS Opinion | NOAEL | =95 | - | rat | oral | Sub-chronic | repeated dose toxicity | p.41 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/d | rat | oral | developmental | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =200 | mg/kg bw/day | rat | oral | 90-day | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =250 | mg/kg | dog | oral | 90-day | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.45 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.40 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rat | oral | Sub-acute | repeated dose toxicity | p.40 |
| SCCS Opinion | NOAEL | =1000 | mg/kg | rat | oral | 90-day | NOAEL study | p.43 |
| SCCS Opinion | NOAEL | =1665 | - | rat | oral | Sub-acute | repeated dose toxicity | p.41 |
| SCCS Opinion | NOAEL | =1687 | - | human | oral | - | repeated dose toxicity | p.26 |
| SCCS Opinion | NOAEL | =12500 | ppm | rat | oral | 9 months | repeated dose toxicity | p.42 |
| SCCS Opinion | NOAEL | =20000 | ppm | rat | oral | 10 weeks | reproductive toxicity | p.47 |
| SCCS Opinion | NOAEL | =25500 | - | human | oral | 500 days | NOAEL study | p.29 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =250 | mg/L | Rat | oral | short-term; 21 days | short-term | LONG_REF=Comp. Biochem. Physiol. C Comp. Pharmacol.81(1): 131-132 Abdel Rahim,A.G. The Effects of Dietary L-Ascorbic Acid on the Absorption and Utilization of Na75SeO3 of Silver-Treated Rats 1985; TITLE=The Effects of Dietary L-Ascorbic Acid on the Absorption and Utilization of Na75SeO3 of Silver-Treated Rats; AUTHOR=Abdel Rahim,A.G.; DOI=10.1016/0742-8413(85)90103-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=105678; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Physiology: Selenium uptake; STUDY_GROUP=ECOTOX:15596126:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c6687cc7eb6bf0172b61c19c89bf9120 |
ToxValDB EPA TSCA 8e 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =2 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20957_Combined.pdf; TOXICOLOGICAL_EFFECT=increased total white blood cell, neutrophil and lymphocyte counts, increased lung weights, increased bronchoalveolar lavage neutrophil, lymphocyte, monocyte counts, proteins, chemoattractants, enzymes, and osteopontin levels, pulmonary inflammation, granular material, and hypertrophy/hyperplasia of the bronchiolar-alveolar junction; STUDY_GROUP=EPA TSCA 8e_dup_-_15957590_15957591_15957592:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e625844411f4653bea002a26900f10e4 |
| ToxValDB EPA TSCA 8e | LEL | =0.8 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20957_Combined.pdf; TOXICOLOGICAL_EFFECT=increased bronchoalveolar lavage neutrophil, lymphocyte, monocyte counts, proteins, chemoattractants, enzymes, and osteopontin levels, pulmonary inflammation, granular material, and hypertrophy/hyperplasia of the bronchiolar-alveolar junction; STUDY_GROUP=EPA TSCA 8e_dup_-_15957590_15957591_15957592:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a44d4aef5ad8920b966f85b4d77a0f8 |
| ToxValDB EPA TSCA 8e | LEL | =10.2 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=090225268023f448_8EHQ-16-20231_Section 8 (e)_N_2076 EPA No Confidentiality Letter CDX.pdf; TOXICOLOGICAL_EFFECT=changes to hematology and clinical chemistry parameters and chemistry and respiratory tract; STUDY_GROUP=EPA TSCA 8e:15957593:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_183bed40d6b245dc5a45b8b933148c3d |
| ToxValDB EPA TSCA 8e | NEL | =0.2 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20957_Combined.pdf; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EPA TSCA 8e_dup_-_15957590_15957591_15957592:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d26438981772cc90a55234573ba9e0ef |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.008 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634633_15634634:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ac70fe0dc022ba81c8a0bf6a1bf50e1 |
ToxValDB IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =0.014 | mg/kg bw/day | Human | oral | - | clinical | LONG_REF=Gaul, L.E. and A.H. Staud. 1935. Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication. J. Am. Med. Assoc. 104: 1387-1390.; TITLE=Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication; AUTHOR=Gaul, L.E. and A.H. Staud; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=99; TOXICOLOGICAL_EFFECT=argyria; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS:15645400:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_011f178d6c24c293703452998bb84177 |
| ToxValDB IRIS | RfD | =0.005 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Gaul, L.E. and A.H. Staud. 1935. Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication. J. Am. Med. Assoc. 104: 1387-1390.; TITLE=Clinical spectroscopy. Seventy cases of generalized argyrosis following organic and colloidal silver medication; AUTHOR=Gaul, L.E. and A.H. Staud; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d76; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=99; TOXICOLOGICAL_EFFECT=argyria; STUDY_GROUP=IRIS:15645401:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e624646d97320469738582bd32245af |
openFDA substances 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3M4G523W1G | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | Q3A5NLA4B5 | UNII | - | - | - | specifiedSubstanceG1 | - |