NOAEL Studies Cosmetic Ingredient

CINEOLE NOAEL Studies

CAS: 470-67-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3100 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_7358; row=6338; data_type=In Vivo; mixture=Chemical; chemical_name=1,4-Cineole; preferred_name=1,4-Cineole; dtxsid=DTXSID3047396; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3047396; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7443; Record_ID=skin_sensitization_invivo_1696; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3047396; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1981: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90146-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3047396
NTP_ICE_skin_sensitization Induction dose per skin area 10800 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7440; Record_ID=skin_sensitization_invivo_1696; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3047396; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=10800; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1981: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90146-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3047396
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7446; Record_ID=skin_sensitization_invivo_1696; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3047396; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1981: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90146-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3047396
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B55JTU839B UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B55JTU839B"}
openFDA substances FDA UNII substance identifier B55JTU839B UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B55JTU839B"}
openFDA substances FDA UNII substance identifier B55JTU839B UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B55JTU839B"}
openFDA substances FDA UNII substance identifier B55JTU839B UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B55JTU839B"}