NOAEL Studies
Cosmetic Ingredient
Citric Acid NOAEL Studies
INCI: CITRIC ACID
CAS: 77-92-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =6730 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10190; row=5430; data_type=In Vivo; mixture=Chemical; chemical_name=Citric acid; preferred_name=Citric acid; dtxsid=DTXSID3020332; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <11700 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10191; row=5431; data_type=In Vivo; mixture=Chemical; chemical_name=Citric acid; preferred_name=Citric acid; dtxsid=DTXSID3020332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10189; row=5433; data_type=In Vivo; mixture=Chemical; chemical_name=Citric acid; preferred_name=Citric acid; dtxsid=DTXSID3020332; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=6618; RecordID=ARPathway2016_1566; DatasetName=ARPathway2016; DTXSID=DTXSID3020332; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
NTP_ICE_eye_irritation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=998; Record_ID=eye_irritation_231; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3020332; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_eye_irritation | Intensity | 0.2 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=995; Record_ID=eye_irritation_1264; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020332; Assay=Vitrigel; Endpoint=Intensity; Response=0.2; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_eye_irritation | Lag time | 30 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=997; Record_ID=eye_irritation_1264; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020332; Assay=Vitrigel; Endpoint=Lag time; Response=30; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_eye_irritation | Plateau level | 15.7 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=994; Record_ID=eye_irritation_1264; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3020332; Assay=Vitrigel; Endpoint=Plateau level; Response=15.7; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
NTP_ICE_skin_irritation 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 9.09 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=2281; Record_ID=skin_irritation_invitro_99; Data_Type=In Vitro; Formulation_ID=MIX790; Formulation_Name=Hydrochloric acid + Sulfuric acid + Citric acid; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=Corrositex; Endpoint=Breakthrough Time; Response=9.09; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 3.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2279; Record_ID=skin_irritation_invitro_2035; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 4.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2280; Record_ID=skin_irritation_invitro_2034; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=4.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 4.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2283; Record_ID=skin_irritation_invitro_2033; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=4.10; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 95.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2273; Record_ID=skin_irritation_invitro_2035; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=95.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 79.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2274; Record_ID=skin_irritation_invitro_2034; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=79.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 84.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2278; Record_ID=skin_irritation_invitro_2033; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=84.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 1.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2275; Record_ID=skin_irritation_invitro_2033; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=1.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 19.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2276; Record_ID=skin_irritation_invitro_2035; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=19.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 32.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=2277; Record_ID=skin_irritation_invitro_2034; Data_Type=In Vitro; Formulation_ID=MIX821; Formulation_Name=Hydrochloric acid 5%, Sulphuric acid 5%, Citric acid 5%; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID3020332; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=32.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020332 |
ToxValDB_ECHA_IUCLID 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | ~75000 | mg/m3 | Guinea Pig | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/3/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15798483:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5caf155c9f3fb68cf78d486150d3ddf8 |
| ToxValDB_ECHA_IUCLID | LEL | >=31100 | mg/m3 | Guinea Pig | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/3/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15799470_15799471:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8df9d34fa462eb6aee60ef0a7ba30baf |
| ToxValDB_ECHA_IUCLID | LEL | <=81000 | mg/m3 | Guinea Pig | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/3/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15799470_15799471:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d54948c7d956bac7195d0ff5ad56a45 |
| ToxValDB_ECHA_IUCLID | LOAEL | =8000 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd7e4b0a7c65d227b7a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/6/2?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829891_15829892:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eed38385c368cd31f828f55bb523270f |
| ToxValDB_ECHA_IUCLID | LOAEL | =2000 | mg/kg bw/day | Mouse | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd7e4b0a7c65d227b87; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/6/2?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846029_15846030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7ff2d2e53565062ba6e5082d48eb05d |
| ToxValDB_ECHA_IUCLID | NOAEL | >241 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d224e4b0a7c65d231a7b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/9/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820603_15825174:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_296f297a610f6ba916b07a18ba1ad2a0 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=2500 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bda52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14400/7/9/3?documentUUID=688ac347-3f66-4697-a477-810a7fdadd00; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824181_15824182_15824183:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_78bcf4a336b941409c39610fe0eb228c |
| ToxValDB_ECHA_IUCLID | NOAEL | >425 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/9/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15825173:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e814fb8f35cef6883e76af30cb7cbd0d |
| ToxValDB_ECHA_IUCLID | NOAEL | >272 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/9/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820603_15825174:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d81b79d90b6ac49e65a46f983c43f773 |
| ToxValDB_ECHA_IUCLID | NOAEL | >295 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf0c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/9/3?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15825175:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_924793e2765d4880c63d75d5840fe03c |
| ToxValDB_ECHA_IUCLID | NOAEL | =4000 | mg/kg bw/day | Rat | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd7e4b0a7c65d227b7a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/6/2?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829891_15829892:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90d0477682e963d553b8e3a2ed02da9f |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Mouse | oral | short-term; 10 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbd7e4b0a7c65d227b87; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/6/2?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846029_15846030:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb942fe460fe437233cb901e034fae78 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1200 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacf9e4b0a7c65d1c1caf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24327/7/6/2?documentUUID=c25e9097-347b-4094-88f1-e3cdbe015500; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850461:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_98e07adbb01ac2efd99458df4a095f8e |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Rat | injection | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620ace4b096bca87824fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15451/7/6/5?documentUUID=c7257dca-af5a-44fb-85f7-bb2c3cfdbbd3; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15853827:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d979c1f19069c6731aefc1cddea08006 |
ToxValDB_ECOTOX 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =15 | % | Rat | injection | acute; 0.125 days | acute | LONG_REF=Braz. Dent. J.16(1): 3-8 De Sousa,S.M.G., C.M. Bramante, and E.M. Taga Biocompatibility of EDTA, EGTA and Citric Acid 2005; TITLE=Biocompatibility of EDTA, EGTA and Citric Acid; AUTHOR=De Sousa,S.M.G., C.M. Bramante, and E.M. Taga; DOI=10.1590/s0103-64402005000100001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101336; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Physiology: Permeability, tissue, membrane; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594445:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=63abb44d1bb6f9bd8dc238f14741c83a |
| ToxValDB_ECOTOX | LOEL | =4 | % | Rat | injection | acute; 0.1667 days | acute | LONG_REF=Metab. Clin. Exp.25(2): 203-209 Reaven,G.M., P.D. Reaven, and E.P. Reaven Hypercalcemia in Acute Uremia and Following Citric Acid Administration: Differential Effect on Parathyroid Gland Microtubule Content 1976; TITLE=Hypercalcemia in Acute Uremia and Following Citric Acid Administration: Differential Effect on Parathyroid Gland Microtubule Content; AUTHOR=Reaven,G.M., P.D. Reaven, and E.P. Reaven; DOI=10.1016/0026-0495(76)90050-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101392; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Calcium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15595240:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2325c82e36792b3796f868d09499dc88 |
| ToxValDB_ECOTOX | LOEL | =124 | mg/L | Mouse | oral | short-term; 30.44 days | short-term | LONG_REF=Res. Commun. Chem. Pathol. Pharmacol.79(3): 377-380 Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet 1993; TITLE=Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet; AUTHOR=Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151648; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Aluminum content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595534_15604890:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a117308d5d17fecb1e722f96f45b1b5d |
| ToxValDB_ECOTOX | LOEL | =3000 | mg/kg bw/day | Rat | injection | acute; 0.1667 days | acute | LONG_REF=Arch. Pharm. Res. (Seoul)27(10): 1037-1042 Saleem,R., M. Ahmad, A. Naz, H. Siddiqui, S.I. Ahmad, and S. Faizi Hypotensive and Toxicological Study of Citric Acid and Other Constituents from Tagetes patula Roots 2004; TITLE=Hypotensive and Toxicological Study of Citric Acid and Other Constituents from Tagetes patula Roots; AUTHOR=Saleem,R., M. Ahmad, A. Naz, H. Siddiqui, S.I. Ahmad, and S. Faizi; DOI=10.1007/BF02975428; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=101728; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15608547:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=815aa3f514d76810d4e9662b3189b4b7 |
| ToxValDB_ECOTOX | LOEL | =100 | mg/kg bw/day | Mouse | injection | short-term; 7 days | short-term | LONG_REF=Arch. Pharm. Res. (Seoul)27(10): 1037-1042 Saleem,R., M. Ahmad, A. Naz, H. Siddiqui, S.I. Ahmad, and S. Faizi Hypotensive and Toxicological Study of Citric Acid and Other Constituents from Tagetes patula Roots 2004; TITLE=Hypotensive and Toxicological Study of Citric Acid and Other Constituents from Tagetes patula Roots; AUTHOR=Saleem,R., M. Ahmad, A. Naz, H. Siddiqui, S.I. Ahmad, and S. Faizi; DOI=10.1007/BF02975428; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101728; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15610600:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3c19a0ba68b65cb1b44d5f91099db463 |
| ToxValDB_ECOTOX | NOEL | =5 | % | Mouse | oral | chronic; 426.16 days | chronic | LONG_REF=Nutr. Rep. Int.13(6): 563-566 Wright,E., and R.E. Hughes The Influence of a Dietary Citric Acid Supplement on the Reproduction and Survival Time of Mice and Rats 1976; TITLE=The Influence of a Dietary Citric Acid Supplement on the Reproduction and Survival Time of Mice and Rats; AUTHOR=Wright,E., and R.E. Hughes; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101393; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594907_15606331:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=955e3a5f4176be5890469e0882dc7a8e |
openFDA substances 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | XF417D3PSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XF417D3PSL"} |
| openFDA substances | FDA UNII substance identifier | GQH5A01T0W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H40N4O3.C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GQH5A01T0W"} |
| openFDA substances | FDA UNII substance identifier | XF417D3PSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XF417D3PSL"} |
| openFDA substances | FDA UNII substance identifier | XF417D3PSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XF417D3PSL"} |
| openFDA substances | FDA UNII substance identifier | XF417D3PSL | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XF417D3PSL"} |
| openFDA substances | FDA UNII substance identifier | GQH5A01T0W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H40N4O3.C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GQH5A01T0W"} |
| openFDA substances | FDA UNII substance identifier | GQH5A01T0W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H40N4O3.C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GQH5A01T0W"} |
| openFDA substances | FDA UNII substance identifier | GQH5A01T0W | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C20H40N4O3.C6H8O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GQH5A01T0W"} |