Moderate Cosmetic Ingredient Sensitization Data Dermal Penetration

Citrol

INCI: CITRAL

CAS Number
Citrol is a trade name; typically refers to Citral (CAS 5392-40-5, mixture of geranial + neral)
Function
Fragrance ingredient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes CIR reviewed; GRAS as flavor; permitted in cosmetics with allergen awareness

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Citrol based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
1.8%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted — max 0.6% in finished products

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Citrol, relevant to systemic exposure and MoS calculations.

Absorption %
18-30%
Penetration Level
epidermis
Penetration Depth
epidermis/dermis
Molecular Weight
152.2 Da
Log P
3.45
Systemic Absorption
yes
Topical Bioavailability
12-25%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

Must be declared as allergen on EU labels; potent sensitizer with high auto-oxidation risk; IFRA category-specific limits apply; verify exact identity due to trade name ambiguity.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Citrol safe in cosmetics?

Must be declared as allergen on EU labels; potent sensitizer with high auto-oxidation risk; IFRA category-specific limits apply; verify exact identity due to trade name ambiguity. The EU classifies Citrol as "restricted". Safety rating: MODERATE.

Is Citrol allowed in the EU?

Citrol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrol do in cosmetics?

Citrol functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: Citrol is a trade name; typically refers to Citral (CAS 5392-40-5, mixture of geranial + neral).

What is the Margin of Safety for Citrol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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