Good Cosmetic Ingredient

Citrus Grandis Seed Extract (Grapefruit Seed Extract)

INCI: CITRUS GRANDIS SEED EXTRACT

CAS Number
90045-43-5
Function
Skin conditioning; antimicrobial; antioxidant. Extract obtained from the seeds of the grapefruit, Citrus grandis (syn. Citrus paradisi). Contains flavonoids (naringenin, hesperidin), limonoids, and vitamin C precursors. Used in cosmetics as a skin conditioning and antioxidant active, with natural preservation-enhancing properties. Reported in 144 cosmetic product uses, with a majority in leave-on skin care preparations.
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically regulated by FDA for cosmetic use. Commercially marketed as a natural preservative booster; FDA has not issued any restriction. Formulators should ensure finished products comply with 21 CFR labeling and safety requirements.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Well-established cosmetic ingredient with CIR-affirmed safety at typical use concentrations, valued for skin conditioning and antioxidant activity with a broad safety profile. No EU restrictions apply; not FDA-regulated as an active. cGMP controls recommended to minimize botanical impurities.

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Concern Level: Low

Regulatory Flags

plant-extract antioxidant skin-conditioning antimicrobial cir-reviewed botanical flavonoids grapefruit fda_food_additive

Frequently Asked Questions

Is Citrus Grandis Seed Extract (Grapefruit Seed Extract) safe in cosmetics?

Well-established cosmetic ingredient with CIR-affirmed safety at typical use concentrations, valued for skin conditioning and antioxidant activity with a broad safety profile. No EU restrictions apply; not FDA-regulated as an active. cGMP controls recommended to minimize botanical impurities. The EU classifies Citrus Grandis Seed Extract (Grapefruit Seed Extract) as "permitted". Safety rating: GOOD.

Is Citrus Grandis Seed Extract (Grapefruit Seed Extract) allowed in the EU?

Citrus Grandis Seed Extract (Grapefruit Seed Extract) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Citrus Grandis Seed Extract (Grapefruit Seed Extract) do in cosmetics?

Citrus Grandis Seed Extract (Grapefruit Seed Extract) functions as: Skin conditioning; antimicrobial; antioxidant. Extract obtained from the seeds of the grapefruit, Citrus grandis (syn. Citrus paradisi). Contains flavonoids (naringenin, hesperidin), limonoids, and vitamin C precursors. Used in cosmetics as a skin conditioning and antioxidant active, with natural preservation-enhancing properties. Reported in 144 cosmetic product uses, with a majority in leave-on skin care preparations.. It is classified as a cosmetic ingredient in our database. CAS number: 90045-43-5.

What is the Margin of Safety for Citrus Grandis Seed Extract (Grapefruit Seed Extract)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Citrus Grandis Seed Extract (Grapefruit Seed Extract) compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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