Citrus Paradisi Peel Extract (Grapefruit Peel Extract)

CIR-affirmed safe for rinse-off and leave-on use when formulated below furocoumarin thresholds. Well-tolerated skin conditioning and antioxidant ingredient with good safety profile; primary concern is furocoumarin-mediated phototoxicity in leave-on products, requiring 5-MOP not to exceed 15 ppm in finished formulation. The EU classifies Citrus Paradisi Peel Extract (Grapefruit Peel Extract) as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Citrus Paradisi Peel Extract (Grapefruit Peel Extract) EU regulatory status: permitted. Maximum allowed concentration: Leave-on products: 15 ppm (0.0015%) 5-methoxypsoralen (5-MOP). This is based on EU Regulation 1223/2009 and its amendments.

Citrus Paradisi Peel Extract (Grapefruit Peel Extract) functions as: Skin conditioning; Antioxidant; Fragrance. Extract obtained from the peel of grapefruit, Citrus paradisi (syn. Citrus grandis). Contains flavonoids (naringin, naringenin), limonene, and furanocoumarins. Provides antioxidant protection and skin conditioning. Reported among the highest-use citrus peel-derived ingredients with 61 total reported uses, more than half in skin care preparations. CIR Expert Panel assessed 47 citrus peel-derived ingredients; concluded they are safe for use in both rinse-off and leave-on cosmetic products when formulated to be non-sensitizing and non-irritating, with leave-on products not exceeding 0.0015% (15 ppm) 5-MOP.. It is classified as a cosmetic ingredient in our database. CAS number: 8016-20-4.

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

The NOAEL (No Observed Adverse Effect Level) for Citrus Paradisi Peel Extract (Grapefruit Peel Extract) is 15000 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. Source: COSMOS_DB.