NOAEL Studies Active Ingredient

Climbazole NOAEL Studies

INCI: CLIMBAZOLE

CAS: 38083-17-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 5 mg/kg bw/day rat oral 90 day Subchronic SCCP; Bayer AG, Institute for Toxicology. BAY e 6975 - Subchronic Toxicological Studies onRats (Treatment through Stomach Tube for 3 Months). Pharma Report No. 7210.Wuppertal
ECHA 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 50 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=c7b14064-75a6-48d1-b23a-b3368dbf37dc_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=c7b14064-75a6-48d1-b23a-b3368dbf37dc/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-01-08; basis=other:; key_result=false; entry_uuid=347f7c01-47a8-447b-af8b-a20ea22a91d9
ECHA NOAEL 45 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=656ca33a-b090-4d36-91ec-9e5e439c3f05_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=656ca33a-b090-4d36-91ec-9e5e439c3f05/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-01-09; basis=other:; key_result=false; entry_uuid=3d50ab4c-ba4a-4134-a443-3d9ee24e2507
ECHA NOAEL 60 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=6fbbc375-0437-4e3f-a4dd-ad9c7dc41d51_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=6fbbc375-0437-4e3f-a4dd-ad9c7dc41d51/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-11-29; basis=other:; key_result=true; entry_uuid=7f7aae77-dc16-469b-bf09-263899d1a356
ECHA NOAEL 100 mg/kg bw/day rat oral: gavage - fertility, other dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=010dacb1-8c3c-421c-b164-30e8b91476bd_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=010dacb1-8c3c-421c-b164-30e8b91476bd/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-03-02; basis=other:; key_result=true; entry_uuid=09d64b10-8f17-446b-ac77-35048c03cc32
ECHA NOAEL 36 mg/kg bw/day rat oral: gavage - fertility, other dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=010dacb1-8c3c-421c-b164-30e8b91476bd_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=010dacb1-8c3c-421c-b164-30e8b91476bd/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1979; ReportDate=1979-03-02; basis=clinical signs; key_result=true; entry_uuid=96d71232-6985-4eba-9fc1-5fc64a3bcbb0
ECHA NOEL 15 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6z; document=6fbbc375-0437-4e3f-a4dd-ad9c7dc41d51_1364b88b-e4e8-47e3-8a26-48e63ddc73db.i6d; document_key=6fbbc375-0437-4e3f-a4dd-ad9c7dc41d51/1364b88b-e4e8-47e3-8a26-48e63ddc73db; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-11-29; basis=other:; key_result=true; entry_uuid=0576cabd-6339-448e-9e19-5f230c015c48
ECHA LOAEC =69.1 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/6/3?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15827862:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4721f23b153074afa43f0948de5cd354
ECHA LOAEL =50 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7ec1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/6/2?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15842923:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1427ae6075de287658800b7d76cf6a11
ECHA NOAEC =44.3 mg/m3 Rat inhalation acute; 6 hours acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/6/3?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15827704:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e55c08276e86996f04d37d0825a6bc15
ECHA NOAEL =60 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd9be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/9/3?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15821188:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5781546d7f3227d812b9a6aa6ba29437
ECHA NOAEL =45 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7eb3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/6/2?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15836378:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be01220da753b989fc72e3ce6552a088
ECHA NOAEL =100 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b828e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/9/2?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15854975:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9db21f799146bcf44b75e04c78bfc029
ECHA NOAEL =36 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b828e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/9/2?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=P0: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15855884:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a40477248a3e1827c455861a1846184
ECHA NOEL =15 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd9be; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11657/7/9/3?documentUUID=1364b88b-e4e8-47e3-8a26-48e63ddc73db; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15822508:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b36956240bee1babfaa1d0b0026eb4d
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_6114; row=10943; data_type=In Vivo; mixture=Chemical; chemical_name=Climbazole; preferred_name=Climbazole; dtxsid=DTXSID6046555; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6046555; source_file=acute_oral.xlsx
SCCS Opinion 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion DERMAL_ABSORPTION =1 % - dermal - in vitro p.11
SCCS Opinion DERMAL_ABSORPTION =0.04 % - dermal - Dermal absorption p.12
SCCS Opinion DERMAL_ABSORPTION =2.3 % - dermal - Dermal absorption Ref.: 20, 21, 23, 68, p.13
SCCS Opinion NOAEL =50 mg/kg bw/day rat oral sub-chronic repeated dose toxicity p.15
SCCS Opinion NOAEL =5 mg/kg bw/day rat oral 13 weeks NOAEL study p.17
SCCS Opinion NOAEL =20 mg/kg bw/day dog - sub-chronic repeated dose toxicity p.18
SCCS Opinion NOAEL =10 mg/kg bw/day dog - sub-chronic repeated dose toxicity p.18
SCCS Opinion NOAEL =7.2 mg/kg bw/day rat oral - NOAEL study p.24
SCCS Opinion NOAEL =30 mg/kg bw/day rat oral - developmental toxicity p.25
SCCS Opinion NOAEL =15 mg/kg bw/day rat oral 6 to day developmental toxicity p.25
SCCS Opinion NOAEL =10 mg/kg rat - - developmental toxicity p.26
SCCS Opinion NOAEL =7.2 mg/kg rat - - developmental toxicity p.28
SCCS Opinion NOAEL =5 mg/kg/day rat oral 90d developmental toxicity p.33
SCCS Opinion NOAEL =0.5 % rat oral 90 day dermal absorption p.24
SCCS Opinion NOAEL =5 mg/kg bw/day rat oral subacute repeated dose toxicity p.16
SCCS Opinion NOAEL =6 - - - - NOAEL study p.6
SCCS Opinion NOAEL =30 mg/kg bw/day rat - - reproductive toxicity p.22
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630676:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0413edf15d15990d6f532335525b1156
Regulatory source 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 5 mg/kg bw/day rat oral 13 weeks - p.17
Regulatory source - =7.2 mg/kg bw/day rat oral - - p.24
Regulatory source - 5 mg/kg bw/day rat - 90-day - p.6
Regulatory source - 6 - - - - - p.6
Regulatory source dermal absorption 0.5 % rat oral 90 day dermal absorption p.24
Regulatory source dermal absorption =5 mg/kg bw/day rat oral 90 day dermal absorption p.23
Regulatory source dermal absorption 5 mg/kg bw/day mouse oral - dermal absorption p.25
Regulatory source developmental toxicity 30 mg/kg bw/day rat oral - developmental toxicity p.25
Regulatory source developmental toxicity 15 mg/kg bw/day rat oral 6 to day developmental toxicity p.25
Regulatory source developmental toxicity 10 mg/kg rat - - developmental toxicity p.26
Regulatory source developmental toxicity 7.2 mg/kg rat - - developmental toxicity p.28
Regulatory source developmental toxicity 5 mg/kg/day rat oral 90d developmental toxicity p.33
Regulatory source developmental toxicity 30 mg/kg bw/day rat oral 90d developmental toxicity p.33
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat oral sub-chronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity 50 mg/kg bw/day - oral sub-chronic repeated dose toxicity p.15
Regulatory source repeated dose toxicity 20 mg/kg bw/day dog - sub-chronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 10 mg/kg bw/day dog - sub-chronic repeated dose toxicity p.18
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral subacute repeated dose toxicity p.16
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat dermal subacute repeated dose toxicity p.25
Regulatory source reproductive toxicity 30 mg/kg bw/day rat - - reproductive toxicity p.22
Regulatory source reproductive toxicity 30 mg/kg bw/day mouse oral - reproductive toxicity p.25
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9N42CW7I54 UNII - - - chemical -