NOAEL Studies Cosmetic Ingredient

Cobalt Chloride NOAEL Studies

INCI: COBALT CHLORIDE

CAS: 7646-79-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE skin sensitization 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 35.5 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1730; Record_ID=skin_sensitization_invitro_453; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=35.5; Reported_Response_Unit=ug/mL; Response=35.5; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization CD86, EC120 9.478 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; mMUSST sheet=Data_invitro; excel_row=7793; Record_ID=skin_sensitization_invitro_1891; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=73; Reported_Response_Unit=uM; Conversion_Factor_Value=129.83; Conversion_Factor_Source=EPA Dashboard; Converted_Response=9.478; Converted_Response_Unit=ug/mL; Response=9.478; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization CV75 208.3 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1655; Record_ID=skin_sensitization_invitro_453; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=h-CLAT; Endpoint=CV75; Reported_Response=208.3; Reported_Response_Unit=ug/mL; Response=208.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization Depletion Cys 30.3 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=211; Record_ID=skin_sensitization_invitro_86; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=30.3; Reported_Response_Unit=%; Response=30.3; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization Depletion Lys 35 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=258; Record_ID=skin_sensitization_invitro_86; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=35; Reported_Response_Unit=%; Response=35; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization EC1.5 <241.13 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7609; Record_ID=skin_sensitization_invitro_1851; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=241.13; Reported_Response_Unit=uM; Response=241.13; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization EC1.5 298.6 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6669; Record_ID=skin_sensitization_invitro_1578; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=298.6; Reported_Response_Unit=uM; Response=298.6; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13156; Record_ID=skin_sensitization_invivo_3176; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Basketter and Scholes 1992; 1544608; 10.1016/0278-6915(92)90138-b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization EC3 0.6 % Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12880; Record_ID=skin_sensitization_invivo_494; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LLNA; Endpoint=EC3; Response=0.6; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization EC3 0.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13154; Record_ID=skin_sensitization_invivo_3174; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LLNA; Endpoint=EC3; Response=0.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Ikarashi et al. 1992; 1471161; 10.1016/0300-483x(92)90196-l; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization IC50 >600 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7678; Record_ID=skin_sensitization_invitro_1851; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=600; Reported_Response_Unit=uM; Response=600; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization IC50 1330.2 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6670; Record_ID=skin_sensitization_invitro_1578; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=1330.2; Reported_Response_Unit=uM; Response=1330.2; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization Imax 7.479 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7727; Record_ID=skin_sensitization_invitro_1851; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LuSens; Endpoint=Imax; Reported_Response=7.479284707; Reported_Response_Unit=Unitless; Response=7.479; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization Imax 23.3 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6671; Record_ID=skin_sensitization_invitro_1578; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.3; Reported_Response_Unit=Unitless; Response=23.3; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
NTP ICE skin sensitization Max stimulation index 7.2 ratio Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12879; Record_ID=skin_sensitization_invivo_494; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9040180; Assay=LLNA; Endpoint=Max stimulation index; Response=7.2; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9040180
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =3 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cf8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11154/7/6/2?documentUUID=9137f1e1-54e1-429c-a8d0-12220a630789; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847201_15849764:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_78cd0c4382b7004f6e878e48b1885878
ECHA NOAEL =25 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d232768; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10215/7/9/3?documentUUID=11c9eae2-8d3f-4570-8900-b8c34533d284; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake|maternal: haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823235_15823245_15823329_15823337_15823378_15823385_15823691_15823744_15823818_15823828:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9464f641183096cc3de27f7c8f9787cb
ECHA NOAEL =100 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f8e4b0a7c65d230ed9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15141?documentUUID=798c1604-6f62-4c23-bab6-38cb284ef762; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15825042:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9aba29ad38da73ba4c51f02aefbdb488
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =250 umol/kg bw Rat injection short-term; 3 days short-term LONG_REF=Pharmacology38(3): 159-166 Rosenberg,D.W., and A. Kappas Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc 1989; TITLE=Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc; AUTHOR=Rosenberg,D.W., and A. Kappas; DOI=10.1159/000138533; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101259; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: Copper (Cu) content|Biochemistry: Zinc content|Physiology: Copper excretion; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596813_15606945:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ce3b6473f762a1c96189c276e091c47
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =0.0881 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630762:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dbd18ac45550a657893302f758fee1fa
ToxValDB HPVIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HPVIS LOAEL =4 mg/kg bw/day Rat oral chronic; 150 days chronic LONG_REF=Murdock, H.R. 1959. Studies on the pharmacology of cobalt chloride. J. Amer. Pharm. Assoc., 48:140-142.Posting date(s) of documents from the HPV Challenge web site from which data have been entered into the HPVIS: January 23, 2003. The documents were received by EPA on Sept 30, 2005; QUALITY=2; EXTERNAL_SOURCE_ID=64103; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1959; ORIGINAL_YEAR=1959; STUDY_GROUP=HPVIS:15640124:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_716a059cc498dac2b811d78ec146adb6
ToxValDB HPVIS NOAEL =180 mg/kg bw/day Mouse oral short-term; 5 days developmental LONG_REF=Seidenberg, J.M., D.G. Anderson, and R.A. Becker. 1986. Validation of an in vivo developmental toxicity screen in the mouse. Teratog. Carcinog. Mutagen., 6:361-374.Posting date(s) of documents from the HPV Challenge web site from which data have been entered into the HPVIS: January 23, 2003. The documents were received by EPA on Sept 30, 2005; QUALITY=2; EXTERNAL_SOURCE_ID=58638; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15642525:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e4826b65c8dc9834f81d17b2e2c97c5f
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier EVS87XF13W UNII - - - chemical -