Is Cocamidoethyl Betaine safe in cosmetics?
Cocamidoethyl Betaine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Cocamidoethyl Betaine
Also known as: EINECS 272-043-5, Miranol C 2M Conc., 1-(2-(Carboxymethoxy)ethyl)-1-(carboxymethyl)-4,5-dihydro-2-norcoco alkyl imidazolium compounds hydroxides inner salts disodium salts, UNII-18L9G3U51M
INCI: COCAMIDOETHYL BETAINE
Cocamidoethyl Betaine (CAS 68650-39-5) is a cosmetic cosmetic ingredient functioning as Surfactant — cleansing; foam boosting; skin conditioning. NOAEL 53 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 68650-39-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant — cleansing; foam boosting; skin conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permitted; reviewed under CIR alkyl betaines group — safe when formulated to be non-sensitizing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cocamidoethyl Betaine.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cocamidoethyl Betaine across SCCS product categories, with measured dermal absorption where available.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Foamant
Softener and conditioner
Solubility enhancer
Surfactant (surface active agent)
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Cocamidoethyl Betaine.
Regulatory Flags
potential-allergen
eu_children_restricted
epa_safer_alternative
Known Synonyms
EINECS 272-043-5
Miranol C 2M Conc.
1-(2-(Carboxymethoxy)ethyl)-1-(carboxymethyl)-4,5-dihydro-2-norcoco alkyl imidazolium compounds hydroxides inner salts disodium salts
UNII-18L9G3U51M
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Softener and conditioner
Cleaning agent
Foamant
Regulatory Lists
children; Europe; Personal care - hair styling and care - shampoo
Europe; Personal care - body hygiene - hand soap
children; Europe; Personal care
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cocamidoethyl Betaine allowed in the EU?
Cocamidoethyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocamidoethyl Betaine do in cosmetics?
Cocamidoethyl Betaine functions as: Surfactant — cleansing; foam boosting; skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68650-39-5.
Compliance Tools
Check Cocamidoethyl Betaine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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