Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Cocamidoethyl Betaine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 53 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
DMAPA and amidoamine impurities may be present as with all amidopropyl/amidoethyl betaines; must be formulated to be non-sensitizing; less clinical data available than for CAPB—relies on read-across; confirm impurity levels
Regulatory Flags
Frequently Asked Questions
Is Cocamidoethyl Betaine safe in cosmetics?
DMAPA and amidoamine impurities may be present as with all amidopropyl/amidoethyl betaines; must be formulated to be non-sensitizing; less clinical data available than for CAPB—relies on read-across; confirm impurity levels The EU classifies Cocamidoethyl Betaine as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Cocamidoethyl Betaine allowed in the EU?
Cocamidoethyl Betaine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocamidoethyl Betaine do in cosmetics?
Cocamidoethyl Betaine functions as: Surfactant — cleansing; foam boosting; skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68650-39-5.
What is the Margin of Safety for Cocamidoethyl Betaine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cocamidoethyl Betaine?
The NOAEL (No Observed Adverse Effect Level) for Cocamidoethyl Betaine is 53 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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