Cocamidopropylamine Oxide
INCI: COCAMIDOPROPYLAMINE OXIDE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Cocamidopropylamine Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 15 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | - | oral | REACH |
| NOEL | 15 mg/kg bw/day | oral | - | oral | REACH |
| NOEL | 15 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Safe for rinse-off products at typical use range 0.07-4.0%. Hemolytic anemia observed at high oral doses (≥150 mg/kg/day in rats). Concentrated formulations (81.5%) cause moderate skin and severe eye irritation. DMAPA and amidoamine impurities are known sensitizers and must be controlled. CIR: Additional data needed for leave-on product safety assessment including dermal absorption and reproductive/developmental toxicology.
Regulatory Flags
Frequently Asked Questions
Is Cocamidopropylamine Oxide safe in cosmetics?
Safe for rinse-off products at typical use range 0.07-4.0%. Hemolytic anemia observed at high oral doses (≥150 mg/kg/day in rats). Concentrated formulations (81.5%) cause moderate skin and severe eye irritation. DMAPA and amidoamine impurities are known sensitizers and must be controlled. CIR: Additional data needed for leave-on product safety assessment including dermal absorption and reproductive/developmental toxicology. The EU classifies Cocamidopropylamine Oxide as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Cocamidopropylamine Oxide allowed in the EU?
Cocamidopropylamine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocamidopropylamine Oxide do in cosmetics?
Cocamidopropylamine Oxide functions as: Surfactant (cleansing), surfactant (foam boosting), surfactant (hydrotrope), hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68155-09-9.
What is the Margin of Safety for Cocamidopropylamine Oxide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cocamidopropylamine Oxide?
The NOAEL (No Observed Adverse Effect Level) for Cocamidopropylamine Oxide is 15 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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