Cocaminopropylamine

INCI: COCAMINOPROPYLAMINE

CAS Number
Not discretely assigned; derived from cocamine (CAS 61788-46-3) with aminopropyl chain; functionally related to dimethylaminopropylamine (DMAPA) derivatives
Function
Antistatic agent, Hair conditioning agent; also used as intermediate for quaternary ammonium synthesis
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA permitted; no specific restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Key concern: DMAPA-related sensitization risk; impurity profile is critical with free DMAPA and amidoamine content requiring minimization. Formulate to minimize free amine content. CPSR assessor will likely require supporting sensitization data or read-across with robust justification. Not to be confused with the safer quaternized derivatives.

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Cocaminopropylamine safe in cosmetics?

Key concern: DMAPA-related sensitization risk; impurity profile is critical with free DMAPA and amidoamine content requiring minimization. Formulate to minimize free amine content. CPSR assessor will likely require supporting sensitization data or read-across with robust justification. Not to be confused with the safer quaternized derivatives. The EU classifies Cocaminopropylamine as "prohibited". Safety rating: MODERATE.

Is Cocaminopropylamine allowed in the EU?

Cocaminopropylamine EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Cocaminopropylamine do in cosmetics?

Cocaminopropylamine functions as: Antistatic agent, Hair conditioning agent; also used as intermediate for quaternary ammonium synthesis. It is classified as a cosmetic ingredient in our database. CAS number: Not discretely assigned; derived from cocamine (CAS 61788-46-3) with aminopropyl chain; functionally related to dimethylaminopropylamine (DMAPA) derivatives.

What is the Margin of Safety for Cocaminopropylamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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