Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Coffea Arabica Seed Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 33 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1483 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1716 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 1958 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1931 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 2489 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 3750 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 3725 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 3775 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
Expert Verdict
CAS 84650-00-0 / EC 283-481-1. EU permitted under Regulation 1223/2009 with no Annex listing and no concentration restriction. FDA permitted under general cosmetic framework; MoCRA-compliant. Safe antioxidant, anti-aging, and skin-conditioning botanical at typical use levels; caffeine content varies widely by grade—always obtain CoA with caffeine assay.
Regulatory Flags
Frequently Asked Questions
Is Coffea Arabica Seed Extract safe in cosmetics?
CAS 84650-00-0 / EC 283-481-1. EU permitted under Regulation 1223/2009 with no Annex listing and no concentration restriction. FDA permitted under general cosmetic framework; MoCRA-compliant. Safe antioxidant, anti-aging, and skin-conditioning botanical at typical use levels; caffeine content varies widely by grade—always obtain CoA with caffeine assay. The EU classifies Coffea Arabica Seed Extract as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Coffea Arabica Seed Extract allowed in the EU?
Coffea Arabica Seed Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Coffea Arabica Seed Extract do in cosmetics?
Coffea Arabica Seed Extract functions as: Skin Conditioning, Antioxidant, Anti-aging, Anti-inflammatory, Anticellulite. It is classified as a Active Ingredient in our database. CAS number: 84650-00-0.
What is the Margin of Safety for Coffea Arabica Seed Extract?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Coffea Arabica Seed Extract?
The NOAEL (No Observed Adverse Effect Level) for Coffea Arabica Seed Extract is 33 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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