Good Cosmetic Ingredient NOAEL Data

Coffea Arabica Seedcake Extract

INCI: COFFEA ARABICA SEEDCAKE EXTRACT

CAS Number
84650-00-0
Function
Skin Conditioning, Antioxidant
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted by FDA; no standalone CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Coffea Arabica Seedcake Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 33 mg/kg bw/day oral mouse Special Toxicology Study COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 1483 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 1716 mg/kg bw/day oral rat Reproductive COSMOS_DB
NOAEL 1958 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1931 mg/kg bw/day oral rat Reproductive COSMOS_DB
NOAEL 2489 mg/kg bw/day oral rat Reproductive-developmental COSMOS_DB
NOAEL 3750 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 3725 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 3775 mg/kg bw/day oral rat Chronic COSMOS_DB

Expert Verdict

Upcycled/byproduct ingredient with good safety profile; extraction solvent residues and microbial load must be controlled due to batch-to-batch variability from source material.

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Concern Level: Low

Regulatory Flags

plant-extract ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Coffea Arabica Seedcake Extract safe in cosmetics?

Upcycled/byproduct ingredient with good safety profile; extraction solvent residues and microbial load must be controlled due to batch-to-batch variability from source material. The EU classifies Coffea Arabica Seedcake Extract as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is Coffea Arabica Seedcake Extract allowed in the EU?

Coffea Arabica Seedcake Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Coffea Arabica Seedcake Extract do in cosmetics?

Coffea Arabica Seedcake Extract functions as: Skin Conditioning, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 84650-00-0.

What is the Margin of Safety for Coffea Arabica Seedcake Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Coffea Arabica Seedcake Extract?

The NOAEL (No Observed Adverse Effect Level) for Coffea Arabica Seedcake Extract is 33 mg/kg bw/day based on a Special Toxicology Study study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

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