Excellent Active Ingredient

Copper Peptide (GHK-Cu, Copper Tripeptide-1)

INCI: COPPER TRIPEPTIDE-1

CAS Number
49557-75-7
Function
GHK-Cu: glycine-histidine-lysine copper complex. Tissue-remodelling tripeptide with copper-dependent activation of fibroblast collagen types I/III and elastin synthesis, glycosaminoglycan production, superoxide dismutase (SOD) activation, wound-healing, and angiogenesis. Anti-aging, barrier repair, and anti-inflammatory activity.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted without restriction. INCI: Copper Tripeptide-1. MoCRA safety substantiation required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHK-Cu (Copper Tripeptide-1) is the best-characterised copper peptide complex with multi-mechanism anti-aging and repair activity supported by decades of academic and commercial research. Well-tolerated with excellent safety profile and unrestricted global regulatory status.

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Concern Level: None

Regulatory Flags

peptide anti-aging collagen-synthesis copper-complex inci-copper-tripeptide-1 skinification body-care-expanding evidence-backed high-demand-2026

Frequently Asked Questions

Is Copper Peptide (GHK-Cu, Copper Tripeptide-1) safe in cosmetics?

GHK-Cu (Copper Tripeptide-1) is the best-characterised copper peptide complex with multi-mechanism anti-aging and repair activity supported by decades of academic and commercial research. Well-tolerated with excellent safety profile and unrestricted global regulatory status. The EU classifies Copper Peptide (GHK-Cu, Copper Tripeptide-1) as "permitted". Safety rating: EXCELLENT.

Is Copper Peptide (GHK-Cu, Copper Tripeptide-1) allowed in the EU?

Copper Peptide (GHK-Cu, Copper Tripeptide-1) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Copper Peptide (GHK-Cu, Copper Tripeptide-1) do in cosmetics?

Copper Peptide (GHK-Cu, Copper Tripeptide-1) functions as: GHK-Cu: glycine-histidine-lysine copper complex. Tissue-remodelling tripeptide with copper-dependent activation of fibroblast collagen types I/III and elastin synthesis, glycosaminoglycan production, superoxide dismutase (SOD) activation, wound-healing, and angiogenesis. Anti-aging, barrier repair, and anti-inflammatory activity.. It is classified as a Active Ingredient in our database. CAS number: 49557-75-7.

What is the Margin of Safety for Copper Peptide (GHK-Cu, Copper Tripeptide-1)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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