Cordycepin

INCI: CORDYCEPIN

CAS Number
73‑03‑0 (pharmacologically active nucleoside)
Function
Antioxidant, anti-inflammatory, skin-conditioning active; often positioned as bioactive fraction of Cordyceps extracts
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA cosmetic monograph; cordycepin is being studied as a drug; in cosmetics it must not be intended to affect structure/function beyond cosmetic scope and must be non-injurious under labelled conditions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pharmacological activity (pro-apoptotic, anti-proliferative) in vitro; theoretical concern for use on damaged skin or in high-frequency regimens; do not formulate for mucosa or children until more data available

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Cordycepin safe in cosmetics?

Pharmacological activity (pro-apoptotic, anti-proliferative) in vitro; theoretical concern for use on damaged skin or in high-frequency regimens; do not formulate for mucosa or children until more data available The EU classifies Cordycepin as "permitted". Safety rating: MODERATE.

Is Cordycepin allowed in the EU?

Cordycepin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Cordycepin do in cosmetics?

Cordycepin functions as: Antioxidant, anti-inflammatory, skin-conditioning active; often positioned as bioactive fraction of Cordyceps extracts. It is classified as a cosmetic ingredient in our database. CAS number: 73‑03‑0 (pharmacologically active nucleoside).

What is the Margin of Safety for Cordycepin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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