Coumaroyl SH-Pentapeptide-5

INCI: COUMAROYL SH-PENTAPEPTIDE-5

CAS Number
Not assigned
Function
Antioxidant, Skin Protecting – product of reaction between coumaric acid and SH-Pentapeptide-5
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA: No specific restrictions. Peptide conjugate under general cosmetic self-regulation.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Thiol (SH-) group requires attention — potential for protein binding and mild irritation at higher concentrations. Supplier tox dossier essential. Read-across from coumaric acid + pentapeptide-5 is the expected CPSR approach.

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Concern Level: Moderate

Frequently Asked Questions

Is Coumaroyl SH-Pentapeptide-5 safe in cosmetics?

Thiol (SH-) group requires attention — potential for protein binding and mild irritation at higher concentrations. Supplier tox dossier essential. Read-across from coumaric acid + pentapeptide-5 is the expected CPSR approach. The EU classifies Coumaroyl SH-Pentapeptide-5 as "permitted". Safety rating: MODERATE.

Is Coumaroyl SH-Pentapeptide-5 allowed in the EU?

Coumaroyl SH-Pentapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Coumaroyl SH-Pentapeptide-5 do in cosmetics?

Coumaroyl SH-Pentapeptide-5 functions as: Antioxidant, Skin Protecting – product of reaction between coumaric acid and SH-Pentapeptide-5. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Coumaroyl SH-Pentapeptide-5?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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