NOAEL Studies
Cosmetic Ingredient
Crotonaldehyde NOAEL Studies
INCI: CROTONALDEHYDE
CAS: 4170-30-3 (mixture); 123-73-9 (E-isomer)
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 5 | mg/kg bw/day | rat | oral: unspecified | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=dd1643a0-f3db-489c-a050-2f8d221f4016_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=dd1643a0-f3db-489c-a050-2f8d221f4016/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=386525dd-36b4-4087-a79a-55425d66e048 |
| ECHA | LOAEL | 40 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=2354275f-bfad-409e-9363-9b49ea12aab5 |
| ECHA | LOAEL | 5 | mg/kg bw/day | rat | oral: unspecified | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=dd1643a0-f3db-489c-a050-2f8d221f4016_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=dd1643a0-f3db-489c-a050-2f8d221f4016/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=386525dd-36b4-4087-a79a-55425d66e048 |
| ECHA | LOAEL | 40 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=2354275f-bfad-409e-9363-9b49ea12aab5 |
| ECHA | LOAEL | 5 | mg/kg bw/day | rat | oral: unspecified | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=dd1643a0-f3db-489c-a050-2f8d221f4016_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=dd1643a0-f3db-489c-a050-2f8d221f4016/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=386525dd-36b4-4087-a79a-55425d66e048 |
| ECHA | LOAEL | 40 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=2354275f-bfad-409e-9363-9b49ea12aab5 |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e3a61ae4-2e6e-476b-a975-a097fb033081_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e3a61ae4-2e6e-476b-a975-a097fb033081/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1987; ReportDate=1987-09-30; key_result=false; entry_uuid=ade81c50-c6e6-4aba-a0f6-5716cd04f0ad |
| ECHA | NOAEL | 20 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=837d2681-e70d-45c8-b11c-450b4f2dbf87 |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e3a61ae4-2e6e-476b-a975-a097fb033081_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e3a61ae4-2e6e-476b-a975-a097fb033081/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1987; ReportDate=1987-09-30; key_result=false; entry_uuid=ade81c50-c6e6-4aba-a0f6-5716cd04f0ad |
| ECHA | NOAEL | 20 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=837d2681-e70d-45c8-b11c-450b4f2dbf87 |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | one-generation reproductive toxicity | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e3a61ae4-2e6e-476b-a975-a097fb033081_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e3a61ae4-2e6e-476b-a975-a097fb033081/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1987; ReportDate=1987-09-30; key_result=false; entry_uuid=ade81c50-c6e6-4aba-a0f6-5716cd04f0ad |
| ECHA | NOAEL | 20 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=53770618-9d2d-43d4-8a18-8ea9b358f48a_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=53770618-9d2d-43d4-8a18-8ea9b358f48a/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=837d2681-e70d-45c8-b11c-450b4f2dbf87 |
| ECHA | NOEL | 175 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e49b43d2-f900-411c-8ec9-346b6124145b_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e49b43d2-f900-411c-8ec9-346b6124145b/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1986-05-06; key_result=false; entry_uuid=ee2b140c-2e18-4319-a3f9-2bb95e027e32 |
| ECHA | NOEL | 175 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e49b43d2-f900-411c-8ec9-346b6124145b_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e49b43d2-f900-411c-8ec9-346b6124145b/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1986-05-06; key_result=false; entry_uuid=ee2b140c-2e18-4319-a3f9-2bb95e027e32 |
| ECHA | NOEL | 175 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=f097537d-b371-46a1-bc3d-46a222fa85dc.i6z; document=e49b43d2-f900-411c-8ec9-346b6124145b_f097537d-b371-46a1-bc3d-46a222fa85dc.i6d; document_key=e49b43d2-f900-411c-8ec9-346b6124145b/f097537d-b371-46a1-bc3d-46a222fa85dc; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1986-05-06; key_result=false; entry_uuid=ee2b140c-2e18-4319-a3f9-2bb95e027e32 |
| ECHA | LOAEL | =1.2 | mg/m3 | Rat | inhalation | subchronic; 3 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/6/3?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15829275:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28a548432b0cf793fe3d1a669b0913d4 |
| ECHA | LOAEL | =40 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae37e4b0a7c65d1c82bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/6/2?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835238_15849468:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0973dd9c4c731830d821aa4f73698412 |
| ECHA | LOAEL | =5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae37e4b0a7c65d1c82c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/6/2?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15849469:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e9533b0862750ce66c434b057198b15 |
| ECHA | NOAEL | =20 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae37e4b0a7c65d1c82bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/6/2?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835238_15849468:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0dca40d2bf8b0b6e45a88c1a652213c6 |
| ECHA | NOAEL | =10 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaafce4b0a7c65d1b84e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/9/2?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860490_15861297:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_da06f247e41e980a8b4468bd5f0e7a05 |
| ECHA | NOEL | =175 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb32e4b0a7c65d22527d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2037/7/6/2?documentUUID=f097537d-b371-46a1-bc3d-46a222fa85dc; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15847488:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_43e93ec112b630045ee7abcf82c5177f |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2020 | IARC Monographs | {"additional_info":"volume_publication_year=2021","evaluation_year":2020,"source_table":"iarc_classifications","volume":"63, 128"} |
NTP ICE acute inhalation 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 9.6 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4580; Record_ID=acute_inhalation_1631; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.6; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 0.2 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4581; Record_ID=acute_inhalation_1444; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 0.2005 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4582; Record_ID=acute_inhalation_2030; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2005; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.6989 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4583; Record_ID=acute_inhalation_2017; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.6989; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.719 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4584; Record_ID=acute_inhalation_2018; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.719; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 8.9729 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4585; Record_ID=acute_inhalation_2019; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=8.9729; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 9.0245 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4586; Record_ID=acute_inhalation_2020; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.0245; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 4.2401 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4587; Record_ID=acute_inhalation_2021; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.2401; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 3.9536 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4588; Record_ID=acute_inhalation_2023; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.9536; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 2.3177 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4589; Record_ID=acute_inhalation_2024; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.3177; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 2.1487 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4590; Record_ID=acute_inhalation_2025; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.1487; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.1202 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4591; Record_ID=acute_inhalation_2026; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.1202; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.0887 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4592; Record_ID=acute_inhalation_2027; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.0887; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 0.2521 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4593; Record_ID=acute_inhalation_2028; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2521; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 4.0109 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4595; Record_ID=acute_inhalation_2016; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.0109; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 0.3 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4596; Record_ID=acute_inhalation_1641; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.3; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.1 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4597; Record_ID=acute_inhalation_1639; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.1; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 1.7 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4598; Record_ID=acute_inhalation_1638; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.7; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 2.4 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4599; Record_ID=acute_inhalation_1636; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.4; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 0.2435 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4600; Record_ID=acute_inhalation_2029; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2435; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
| NTP ICE acute inhalation | LC50 | 4.8 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4601; Record_ID=acute_inhalation_1633; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.8; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=9144; Record_ID=cancer_1556; Data_Type=WOE; Formulation_Name=Crotonaldehyde; Mixture=Chemical; DTXSID=DTXSID8024864; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/81; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024864 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =60201.2 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=DOE Protective Action Criteria:15513928:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efefbc75d71eea889914c6a6ada5aeb5 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.86 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630836_15630837:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e879651fb30093e6b613f1e65f7e48ce |
| ToxValDB GESTIS DNEL | DNEL systemic | =0.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630836_15630837:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_630e32565a68b4b4732a309303b389b6 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.001 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649957:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4546678d50dfa318ea96e65335f44263 |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =1.60536 | mg/m3 | Human | inhalation | acute; 8 hours | clinical | LONG_REF=Fannick, N. 1982. Health Hazard Evaluation Report: Sandoz Colors and Chemicals, East Hanover, New Jersey. HETA-81-102-1244. Cincinnati, OH: National Institute for Occupational Safety and Health; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b1d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/crotonaldehyde.pdf; YEAR=revised August 23, 2016; ORIGINAL_YEAR=revised August 23, 2016; TOXICOLOGICAL_EFFECT=Intermittent minor eye irritation; STUDY_GROUP=TX TCEQ:15954395:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea523bbebfc412942d7d43029126a03d |