| ToxValDB ECOTOX |
LOEL |
=0.192 |
mg/kg bw/day |
Rat |
oral |
subchronic; 42 days |
subchronic |
LONG_REF=Metab. Brain Dis.16(3-4): 199-205 Parmar,P., and S. Daya The Effect of Copper on (3H)-Tryptophan Metabolism in Organ Cultures of Rat Pineal Glands 2001; TITLE=The Effect of Copper on (3H)-Tryptophan Metabolism in Organ Cultures of Rat Pineal Glands; AUTHOR=Parmar,P., and S. Daya; DOI=10.1023/a:1012545112031; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=77764; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Hormone(s): Serotonin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15604533:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=02e94e03ab41ac9e398fb230d5fea8e5 |
| ToxValDB ECOTOX |
LOEL |
=64 |
mg/L |
Rat |
oral |
short-term; 14 days |
short-term |
LONG_REF=Acta Pharmacol. Toxicol.53:33-38 Komulainen,H. Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats 1983; TITLE=Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats; AUTHOR=Komulainen,H.; DOI=10.1111/j.1600-0773.1983.tb01864.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=73169; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596219_15596220:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9898afd13582a3b15fc277a624e7186f |
| ToxValDB ECOTOX |
LOEL |
=110 |
mg/kg bw/day |
Mouse |
oral |
short-term; 3 days |
short-term |
LONG_REF=Nanotoxicology6(1): 1-21 Manna,P., M. Ghosh, J. Ghosh, J. Das, and P.C. Sil Contribution of Nano-Copper Particles to In Vivo Liver Dysfunction and Cellular Damage: Role of IkBa/NF-KB, MAPKs and Mitochondrial Signal 2012; TITLE=Contribution of Nano-Copper Particles to In Vivo Liver Dysfunction and Cellular Damage: Role of IkBa/NF-KB, MAPKs and Mitochondrial Signal; AUTHOR=Manna,P., M. Ghosh, J. Ghosh, J. Das, and P.C. Sil; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=165661; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Reactive oxygen species|Enzyme(s): Alanine transaminase (ALT)|Morphology: Organ weight in relationship to body weight|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight|other; STUDY_GROUP=ECOTOX:15608600:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c5231896116476f1a3e7c23b1bffe431 |
| ToxValDB ECOTOX |
LOEL |
=1000 |
mg/L |
Rat |
oral |
subchronic; 84 days |
subchronic |
LONG_REF=Hum. Exp. Toxicol.17(10): 570-576 Bataineh,H., M.H. Al-Hamood, and A.M. Elbetieha Assessment of Aggression, Sexual Behavior and Fertility in Adult Male Rat Following Long-Term Ingestion of Four Industrial Metals Salts 1998; TITLE=Assessment of Aggression, Sexual Behavior and Fertility in Adult Male Rat Following Long-Term Ingestion of Four Industrial Metals Salts; AUTHOR=Bataineh,H., M.H. Al-Hamood, and A.M. Elbetieha; DOI=10.1177/096032719801701008; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=58230; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Behavior: Aggression|Growth: Weight|Morphology: Weight|Reproduction: Mounting, copulation, intercourse|Reproduction: Time to mounting; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|neurobehavior|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594787_15595258:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3824afcd315eac026ead24166650a99a |
| ToxValDB ECOTOX |
NOEL |
=50 |
mg/L |
Rat |
oral |
short-term; 14 days |
short-term |
LONG_REF=Acta Pharmacol. Toxicol.53:33-38 Komulainen,H. Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats 1983; TITLE=Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats; AUTHOR=Komulainen,H.; DOI=10.1111/j.1600-0773.1983.tb01864.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=73169; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596219_15596220:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b65aca5a628e2dbde10579b810d1176c |
| ToxValDB ECOTOX |
NOEL |
=76.8 |
mg/kg bw/day |
Rat |
oral |
subchronic; 42 days |
subchronic |
LONG_REF=Biol. Trace Elem. Res.77(3): 241-249 Tatum,L., P. Shankar, L.M. Boylan, and J.E. Spallholz Effect of Dietary Copper on Selenium Toxicity in Fischer 344 Rats 2000; TITLE=Effect of Dietary Copper on Selenium Toxicity in Fischer 344 Rats; AUTHOR=Tatum,L., P. Shankar, L.M. Boylan, and J.E. Spallholz; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76894; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Biochemistry: Selenium content|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594819_15599504:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05f14dcfe3919614f6a7e8aec7284f9a |
| ToxValDB ECOTOX |
NOEL |
=100 |
mg/kg bw/day |
Rat |
oral |
acute; 1 days |
acute |
LONG_REF=Acta Pharmacol. Toxicol.53:33-38 Komulainen,H. Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats 1983; TITLE=Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats; AUTHOR=Komulainen,H.; DOI=10.1111/j.1600-0773.1983.tb01864.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=73169; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599918_15603646_15603894_15603895_15605894:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=69025aa4358b0c2594a85126dda95289 |
| ToxValDB ECOTOX |
NOEL |
=200 |
mg/kg bw/day |
Rat |
oral |
acute; 1 days |
acute |
LONG_REF=Acta Pharmacol. Toxicol.53:33-38 Komulainen,H. Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats 1983; TITLE=Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats; AUTHOR=Komulainen,H.; DOI=10.1111/j.1600-0773.1983.tb01864.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=73169; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599918_15603646_15603894_15603895_15605894:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=85abb31b92c2575f8fe3da867dc9daa9 |
| ToxValDB ECOTOX |
NOEL |
=300 |
mg/kg bw/day |
Rat |
oral |
acute; 1 days |
acute |
LONG_REF=Acta Pharmacol. Toxicol.53:33-38 Komulainen,H. Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats 1983; TITLE=Monoamine Uptake in Brain Synaptosomes After Administration of Copper to Rats; AUTHOR=Komulainen,H.; DOI=10.1111/j.1600-0773.1983.tb01864.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=73169; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599918_15603646_15603894_15603895_15605894:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cf37d2c6c21fc3886a73b6eb2fbba3e4 |